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Deoxyribonucleic acid sequence of a gene from the Pseudomonas transposon TN501 encoding mercuric reductase
Abstract
We have determined the nucleotide sequence of the merA gene from the mercury-resistance transposon Tn501 and have predicted the structure of the gene product, mercuric reductase. The DNA sequence predicts a polypeptide of Mr 58 660, the primary structure of which shows strong homologies to glutathione reductase and lipoamide dehydrogenase, but mercuric reductase contains as additional N-terminal region that may form a separate domain. The implications of these comparisons for the tertiary structure and mechanism of mercuric reductase are discussed. The DNA sequence presented here has an overall G+C content of 65.1 mol%, typical of the bulk DNA of Pseudomonas aeruginosa from which Tn501 was originally isolated. Analysis of the codon usage in the merA gene shows that codons with C or G at the third position are preferentially utilized.
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Cited by
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Barkay, T., Miller, S. M., & Summers, A. O. (2003) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(03)00046-9 · Cited by 1,054
Redesign of the coenzyme specificity of a dehydrogenase by protein engineering
Scrutton, N. S., Berry, A., & Perham, R. N. (1990) · Nature · doi:10.1038/343038a0 · Cited by 730
The guanine and cytosine content of genomic DNA and bacterial evolution.
Muto, A., & Osawa, S. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.1.166 · Cited by 578
Mechanisms of flavoprotein‐catalyzed reactions
GHISLA, S., & MASSEY, V. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb14688.x · Cited by 566
Refined structure of glutathione reductase at 1.54 Å resolution
Karplus, P. A., & Schulz, G. E. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90191-4 · Cited by 502
Metadata
- Authors
- Brown, N. L., Ford, S. J., Pridmore, R. D., & Fritzinger, D. C.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1983-08-16
- Volume
- 22
- Issue
- 17
- Pages
- 4089-4095
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2295412389
- Cited by
- 225
- References
- 0
- FWCI
- 10.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Deoxyribonucleic acid sequence of a gene from the Pseudomonas transposon TN501 encoding mercuric reductase. https://app.cochat.ai/papers/10.1021/bi00286a015
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- Brown, N. L., Ford, S. J., Pridmore, R. D., & Fritzinger, D. C. (1983). Deoxyribonucleic acid sequence of a gene from the Pseudomonas transposon TN501 encoding mercuric reductase. Biochemistry. https://doi.org/10.1021/bi00286a015
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