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The guanine and cytosine content of genomic DNA and bacterial evolution.
Open accessAbstract
The genomic guanine and cytosine (G + C) content of eubacteria is related to their phylogeny. The G + C content of various parts of the genome (protein genes, stable RNA genes, and spacers) reveals a positive linear correlation with the G + C content of their genomic DNA. However, the plotted correlation slopes differ among various parts of the genome or among the first, second, and third positions of the codons depending on their functional importance. Facts suggest that biased mutation pressure, called A X T/G X C pressure, has affected whole DNA during evolution so as to determine the genomic G + C content in a given bacterium. The role of A X T/G X C pressure in diversification of bacterial DNA sequences and codon usage patterns is discussed in the perspective of the neutral theory of molecular evolution.
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Cited by
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Ochman, H., Lawrence, J. G., & Groisman, E. A. (2000) · Nature · doi:10.1038/35012500 · Cited by 3,816
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Razin, S., Yogev, D., & Naot, Y. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.4.1094-1156.1998 · Cited by 1,930
Extreme genome reduction in symbiotic bacteria
McCutcheon, J. P., & Moran, N. A. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2670 · Cited by 1,464
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Moran, N. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2873 · Cited by 1,017
Evidence That Mutation Is Universally Biased towards AT in Bacteria
Hershberg, R., & Petrov, D. A. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001115 · Cited by 490
Metadata
- Authors
- Muto, A., & Osawa, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-01
- Volume
- 84
- Issue
- 1
- Pages
- 166-169
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2119490692
- Cited by
- 578
- References
- 0
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- green
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