The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Metal ion requirements and other aspects of the reaction catalyzed by M1 RNA, the RNA subunit of ribonuclease P from Escherichia coli
Abstract
M1 RNA, the RNA subunit of ribonuclease P from Escherichia coli, can under certain conditions catalytically cleave precursors to tRNA in the absence of C5, the protein moiety of RNase P. M1 RNA itself is not cleaved during the reaction, nor does it form any covalent bonds with its substrate. Only magnesium and, to a lesser extent, manganese ions can function at the catalytic center of M1 RNA. Several other ions either inhibit the binding of magnesium ion at the active site or function as structural counterions. The reaction rate of cleavage of precursors to tRNAs by M1 RNA is enhanced in the presence of poly-(ethylene glycol) or 2-methyl-2,4-pentanediol. Many aspects of the reaction catalyzed by M1 RNA are compatible with a mechanism in which phosphodiester bond cleavage is mediated by metal ion.
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Citations
Cites
The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N., & Altman, S. (1983) · Cell · doi:10.1016/0092-8674(83)90117-4 · Cited by 2,684
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Cited by
A general two-metal-ion mechanism for catalytic RNA
Steitz, T. A., & Steitz, J. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6498 · Cited by 1,171
Wilcox, D. E. (1996) · Chemical Reviews · doi:10.1021/cr950043b · Cited by 893
Structure of ribonuclease H phased at 2 a resolution by MAD analysis of the selenomethionyl protein
Yang, W., Hendrickson, W. A., Crouch, R. J., & Satow, Y. (1990) · Science · doi:10.1126/science.2169648 · Cited by 473
The case for an ancestral genetic system involving simple analogues of the nucleotides.
Joyce, G. F., Schwartz, A. W., Miller, S. L., & Orgel, L. E. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.13.4398 · Cited by 387
External Guide Sequences for an RNA Enzyme
Forster, A. C., & Altman, S. (1990) · Science · doi:10.1126/science.1697102 · Cited by 309
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Metadata
- Authors
- Guerrier-Takada, C., Haydock, K., Allen, L., & Altman, S.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1986-04-08
- Volume
- 25
- Issue
- 7
- Pages
- 1509-1515
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W1978847377
- Cited by
- 175
- References
- 1
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Guerrier-Takada, C., Haydock, K., Allen, L., & Altman, S. (1986). Metal ion requirements and other aspects of the reaction catalyzed by M1 RNA, the RNA subunit of ribonuclease P from Escherichia coli. Biochemistry. https://doi.org/10.1021/bi00355a006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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