The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica
Abstract
Acetylcholine receptor extracted in detergent solution from the electric tissue of Torpedo californica and purified by affinity chromatography contains predominantly two molecular weight species. These have been separated by sedimentation in a sucrose density gradient, and their molecular properties have been determined by sedimentation equilibrium and sedimentation velocity measurements in the analytical ultracentrifuge. The molecular weights of these species have been determined, without prior determination of the extent of detergent bound to them, by the adjustment of solvent density with D2O so as to blank out the contribution of bound detergent to the sedimentation potential. The molecular weights of the protein moieties are 250 000 and 500 000. Since these species are identical in specific activity and polypeptide composition they are related as monomer and dimer. The hydrodynamic properties of the detergent complexes of monomer and dimer were derived from combined measurements of sedimentation equilibrium and sedimentation velocity. The S20,w'S are 8.6 S and 12.8 S and the Stokes radii are 7.3 nm and 9.5 nm. For both monomer and dimer, the ratio of the Stokes radius to the minimum possible radius for the protein-detergent complex falls outside the range of values for globular proteins.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 317,331
Phosphorus Assay in Column Chromatography
Bartlett, G. R. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70226-3 · Cited by 12,801
Molecular characterization of proteins in detergent solutions
Tanford, C., Nozaki, Y., Reynolds, J. A., et al. (1974) · Biochemistry · doi:10.1021/bi00708a021 · Cited by 494
Self-citationBinding of α-Bungarotoxin to Acetylcholine Receptors In Mammalian Muscle
Berg, D. K., Kelly, R. B., Sargent, P. B., Williamson, P., & Hall, Z. W. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.1.147 · Cited by 285
Affinity-labeling of purified acetylcholine receptor from Torpedo californica
Weill, C. L., McNamee, M. G., & Karlin, A. (1974) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(74)90254-x · Cited by 244
Self-citationKlett, R. P., Fulpius, B. W., Cooper, D., Smith, M., Reich, E., & Possani, L. D. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43428-5 · Cited by 244
Chang, H. W., & Bock, E. (1977) · Biochemistry · doi:10.1021/bi00639a028 · Cited by 184
Raftery, M. A., VANDLEN, R. L., Reed, K., et al. (1976) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1976.040.01.021 · Cited by 146
Reynolds, J. A., & Tanford, C. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.12.4467 · Cited by 135
Self-citationKarlin, A., & Cowburn, D. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.12.3636 · Cited by 132
Self-citation
Cited by
Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pH
Jasti, J., Furukawa, H., Gonzales, E. B., & Gouaux, E. (2007) · Nature · doi:10.1038/nature06163 · Cited by 1,043
Acetylcholine Receptor Channel Structure Probed in Cysteine-Substitution Mutants
Akabas, M. H., Stauffer, D. A., Xu, M., & Karlin, A. (1992) · Science · doi:10.1126/science.1384130 · Cited by 665
Self-citationAcetylcholine Receptor: An Allosteric Protein
Changeux, J.-P., Devillers-Thiéry, A., & Chemouilli, P. (1984) · Science · doi:10.1126/science.6382611 · Cited by 623
Allosteric Receptors after 30 Years
Changeux, J.-P., & Edelstein, S. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80616-9 · Cited by 431
Kao, P. N., & Karlin, A. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83877-2 · Cited by 366
Self-citation
Metadata
- Authors
- Reynolds, J. A., & Karlin, A.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1978-05-30
- Volume
- 17
- Issue
- 11
- Pages
- 2035-2038
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W1987115674
- Cited by
- 383
- References
- 14
- FWCI
- 14.87
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica. https://app.cochat.ai/papers/10.1021/bi00604a001
- The paper
- Reynolds, J. A., & Karlin, A. (1978). Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica. Biochemistry. https://doi.org/10.1021/bi00604a001
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
