The DOI matches its Crossref record.
Effect of chelating agents and metal ions on the degradation of DNA by bleomycin
Abstract
The degradation of DNA by bleomycin was studied in the absence and in the presence of added reducing agents, including 2-mercaptoethanol, dithiothreitol, reduced nicotinamide adenine dinucleotide phosphate, H2O2, and ascorbate, and in the presence of a superoxide anion generating system consisting of xanthine oxidase and hypoxanthine. In all cases, breakage of DNA was inhibited by low concentrations of chelators; where examined in detail, deferoxamine mesylate was considerably more potent than (ethylenedinitrilo)tetraacetic acid. Iron was found to be present in significant quantities in all reaction mixtures. Thus, the pattern of inhibition observed is attributed to the involvement of contaminating iron in the degradation of DNA by bleomycin. Cu(II), Zn(II), and Co(II) inhibit degradation of DNA by bleomycin and Fe(II) in the absence of added reducing agents. A model is proposed in which the degradation of DNA in these systems is dependent on the oxidation of an Fe(II)-bleomycin-DNA complex.
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Citations
Cited by
Superoxide radical and superoxide dismutases
Fridovich, I. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.000525 · Cited by 3,455
Pogozelski, W. K., & Tullius, T. D. (1998) · Chemical Reviews · doi:10.1021/cr960437i · Cited by 1,018
Teicher, B. A. (1994) · Cancer and Metastasis Reviews · doi:10.1007/bf00689633 · Cited by 563
Chevion, M. (1988) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(88)90059-7 · Cited by 508
Bleomycin‐induced strand‐scission of DNA. Mechanism of deoxyribose cleavage
Giloni, L., Takeshita, M., Johnson, F., Iden, C., & Grollman, A. P. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68888-5 · Cited by 412
Metadata
- Authors
- Sausville, E. A., Peisach, J., & Horwitz, S. B.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1978-07-11
- Volume
- 17
- Issue
- 14
- Pages
- 2740-2746
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2075249158
- Cited by
- 366
- References
- 0
- FWCI
- 29.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effect of chelating agents and metal ions on the degradation of DNA by bleomycin. https://app.cochat.ai/papers/10.1021/bi00607a007
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- Sausville, E. A., Peisach, J., & Horwitz, S. B. (1978). Effect of chelating agents and metal ions on the degradation of DNA by bleomycin. Biochemistry. https://doi.org/10.1021/bi00607a007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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