Hypoxia and drug resistance

Teicher, Beverly A.

doi:10.1007/bf00689633

Cited by 564Cancer, Hypoxia, and MetabolismBioactive Compounds and Antitumor AgentsCancer Cells and Metastasis

Hypoxia and drug resistance

Teicher, Beverly A.·1994·Cancer and Metastasis Reviews

DOI 10.1007/bf00689633

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Abstract

Biologically and therapeutically important hypoxia occurs in many solid tumor masses. Hypoxia can be a direct cause of therapeutic resistance because some drugs and radiation require oxygen to be maximally cytotoxic. Cellular metabolism is altered under hypoxic conditions. Hypoxia can result in drug resistance indirectly if under this condition cells more effectively detoxify the drug molecules. Finally, there is evidence that hypoxia can enhance genetic instability in tumor cells thus allowing more rapid development of drug resistance cells. The current review describes the effects of hypoxia on tumor response to a variety of anti-cancer agents and also describes progress toward therapeutically useful methods of delivering oxygen to tumors in an effort to overcome therapeutic resistance due to hypoxia. Finally, the use of hypoxic cell selective cytotoxic agents as a means of addressing hypoxic 'drug resistance' is discussed.

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Hypoxic tumor is often resistant to drugs, limiting chemotherapy efficacy.
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The impact of O2 availability on human cancer
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Authors: Teicher, B. A.
Affiliations: Dana-Farber Cancer Institute (US)
Corresponding author: Teicher, Beverly A.
ORCID: Teicher, Beverly A.
Venue: Cancer and Metastasis Reviews
Publisher: Springer Science and Business Media LLC
Published: 1994
Volume: 13
Issue: 2
Pages: 139-168
ISSN: 0167-7659 (ISSN-L)
1573-7233
DOI: 10.1007/bf00689633
OpenAlex: W2065176645
Cited by: 563
References: 241
Citations by year: 2026: 7 · 2025: 10 · 2024: 14 · 2023: 16 · 2022: 9 · 2021: 21 · 2020: 13 · 2019: 26 · 2018: 19 · 2017: 21 · 2016: 24 · 2015: 21 · 2014: 24 · 2013: 15 · 2012: 23
FWCI: 0.51
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Cancer and Metastasis Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
U.S. Public Health Service (P01-38493, R01-50174, P01-19589)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: tumor hypoxia, drug resistance, solid tumors, cellular metabolism, drug detoxification, genomic instability, radioresistance (biology)
MeSH terms: Animals, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Drug Resistance, Humans, Neoplasms, Neoplasms, Experimental, Oxygen, Cell Hypoxia

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