The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Nonspecific interaction of lac repressor with DNA: an association reaction driven by counterion release
Abstract
We have investigated the nonspecific interaction of lac repressor protein with DNA by a quantitative application of DNA-cellulose chromatography (deHaseth, P.L., et al. (1977), Biochemistry 16 (third of five papers in a series in this issue)). The observed association constant for the interaction, KRD obsd, is a sensitive function of ion concentrations and pH. Application of binding theory to interpret these effects gives the results that 11 +/- 2 monovalent ions are released in the interaction and two groups on repressor must be protonated for repressor to bind to DNA. We argue that much of the ion release results from the displacement of cations from the DNA, and estimate on this basis that 12 +/- 2 phosphates are involved in ionic interactions with the protein. Ion release drives the protonation reaction and the overall repressor-DNA interaction. The major role of low molecular weight ions in the repressor-DNA interaction suggests that ion concentration changes must be considered in discussing mechanisms of control of gene expression.
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Citations
Cites
McGhee, J. D., & von Hippel, P. H. (1974) · Journal of Molecular Biology · doi:10.1016/0022-2836(74)90031-x · Cited by 2,952
Linked Functions and Reciprocal Effects in Hemoglobin: A Second Look
Wyman, J. (1964) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60190-4 · Cited by 1,608
Ion effects on ligand-nucleic acid interactions
Record, M. T., Lohman, T. M., & Haseth, P. D. (1976) · Journal of Molecular Biology · doi:10.1016/s0022-2836(76)80023-x · Cited by 1,026
Self-citationlac repressor-operator interaction
Riggs, A. D., Suzuki, H., & Bourgeois, S. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90219-6 · Cited by 781
Lac represser-operator interaction
Jobe, A., & Bourgeois, S. (1973) · Journal of Molecular Biology · doi:10.1016/0022-2836(73)90023-5 · Cited by 681
Lin, S.-Y., & Riggs, A. D. (1975) · Cell · doi:10.1016/0092-8674(75)90116-6 · Cited by 338
Hippel, P. H. V., Revzin, A., Gross, C. A., & Wang, A. C. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.12.4808 · Cited by 235
Allosteric interpretation of haemoglobin properties
Shulman, R. G., Hopfield, J. J., & Ogawa, S. (1975) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583500001840 · Cited by 210
Manning, G. S. (1972) · Biopolymers · doi:10.1002/bip.1972.360110502 · Cited by 182
lac repressor-operator interaction. Analysis of the X86 repressor mutant
Pfahl, M. (1976) · Journal of Molecular Biology · doi:10.1016/0022-2836(76)90269-2 · Cited by 42
Lac repressor binding to poly [d(A-T)]. Conformational changes
Maurizot, J., Charlier, M., & Hélène, C. (1974) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(74)90406-9 · Cited by 39
Conformational transitions of the lac repressor from Escherichia coli
Wu, F. Y.-H., Bandyopadhyay, P. K., & Wu, C.-W. (1976) · Journal of Molecular Biology · doi:10.1016/s0022-2836(76)80040-x · Cited by 26
Cited by
Diffusion-driven mechanisms of protein translocation on nucleic acids. 1. Models and theory
Berg, O. G., Winter, R. B., & Von Hippel, P. H. (1981) · Biochemistry · doi:10.1021/bi00527a028 · Cited by 1,298
Lohman, T. M., & Overman, L. B. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83663-3 · Cited by 364
Self-citationInteractions of bacteriophage T4-coded gene 32 protein with nucleic acids
Kowalczykowski, S. C., Lonberg, N., Newport, J. W., & von Hippel, P. H. (1981) · Journal of Molecular Biology · doi:10.1016/0022-2836(81)90335-1 · Cited by 339
Martin, E. W., & Holehouse, A. S. (2020) · Emerging Topics in Life Sciences · doi:10.1042/etls20190164 · Cited by 281
Richey, B., Cayley, D. S., Mossing, M. C., Kolka, C., Anderson, C. F., Farrar, T. C., & Record, M. T. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48218-x · Cited by 270
Self-citation
Metadata
- Authors
- DeHaseth, P. L., Lohman, T. M., & Record, M. T.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1977-11-01
- Volume
- 16
- Issue
- 22
- Pages
- 4783-4790
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2090759101
- Cited by
- 262
- References
- 12
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
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