The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Evidence for an Active-Center Histidine in Trypsin through Use of a Specific Reagent, 1-Chloro-3-tosylamido-7-amino-2-heptanone, the Chloromethyl Ketone Derived from Nα-Tosyl-L-lysine*
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEvidence for an Active-Center Histidine in Trypsin through Use of a Specific Reagent, 1-Chloro-3-tosylamido-7-amino-2-heptanone, the Chloromethyl Ketone Derived from Nα-Tosyl-L-lysine*Elliott Shaw, Marcos Mares-Guia, and William CohenCite this: Biochemistry 1965, 4, 10, 2219–2224Publication Date (Print):October 1, 1965Publication History Published online1 May 2002Published inissue 1 October 1965https://pubs.acs.org/doi/10.1021/bi00886a039https://doi.org/10.1021/bi00886a039research-articleACS PublicationsRequest reuse permissionsArticle Views665Altmetric-Citations440LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Automatic Recording Apparatus for Use in Chromatography of Amino Acids
Spackman, D. H., Stein, W. H., & Moore, S. (1958) · Analytical Chemistry · doi:10.1021/ac60139a006 · Cited by 9,585
The preparation and properties of two new chromogenic substrates of trypsin
Erlanger, B. F., Kokowsky, N., & Cohen, W. (1961) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(61)90145-x · Cited by 3,353
Self-citationA MODIFIED SPECTROPHOTOMETRIC DETERMINATION OF CHYMOTRYPSIN, TRYPSIN, AND THROMBIN
Hummel, B. C. W. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-157 · Cited by 1,837
Fahrney, D. E., & Gold, A. M. (1963) · Journal of the American Chemical Society · doi:10.1021/ja00890a037 · Cited by 649
Direct Evidence for the Presence of Histidine in the Active Center of Chymotrypsin*
Schoellmann, G., & Shaw, E. (1963) · Biochemistry · doi:10.1021/bi00902a008 · Cited by 643
Self-citationAmino-Acid Sequence of Bovine Chymotrypsinogen-A
HARTLEY, B. S. (1964) · Nature · doi:10.1038/2011284a0 · Cited by 373
Studies on the Active Center of Trypsin
Mares-Guia, M., & Shaw, E. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)97474-0 · Cited by 330
Self-citationNonspecific Catalyses by α-Chymotrypsin and Trypsin
Inagami, T., & Sturtevant, J. M. (1960) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69472-4 · Cited by 151
Dixon, G. H., Go, S., & Neurath, H. (1956) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(56)90414-0 · Cited by 50
Synthesis of ∈-aspartyl-lysines and of isohexylamides of aspartic acid
Swallow, D. L., Lockhart, I. M., & Abraham, E. P. (1958) · Biochemical Journal · doi:10.1042/bj0700359 · Cited by 20
Cited by
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
Powers, J. C., Asgian, J. L., Ekici, Ö. D., & James, K. E. (2002) · Chemical Reviews · doi:10.1021/cr010182v · Cited by 1,090
Metadata
- Authors
- Shaw, E., Mares-Guia, M., & Cohen, W.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1965-10-01
- Volume
- 4
- Issue
- 10
- Pages
- 2219-2224
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2022174848
- Cited by
- 517
- References
- 10
- FWCI
- 19.84
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Evidence for an Active-Center Histidine in Trypsin through Use of a Specific Reagent, 1-Chloro-3-tosylamido-7-amino-2-heptanone, the Chloromethyl Ketone Derived from Nα-Tosyl-L-lysine*. https://app.cochat.ai/papers/10.1021/bi00886a039
- The paper
- Shaw, E., Mares-Guia, M., & Cohen, W. (1965). Evidence for an Active-Center Histidine in Trypsin through Use of a Specific Reagent, 1-Chloro-3-tosylamido-7-amino-2-heptanone, the Chloromethyl Ketone Derived from Nα-Tosyl-L-lysine*. Biochemistry. https://doi.org/10.1021/bi00886a039
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
