The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Molecular-Level Organization of Saturated and Polyunsaturated Fatty Acids in a Phosphatidylcholine Bilayer Containing Cholesterol
Abstract
Cholesterol's preference for specific fatty acid chains is investigated at the atomic level in a 20 ns molecular dynamics computer simulation of a lipid bilayer membrane consisting of cholesterol and 1-stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine (SDPC) in a 1:3 ratio. These simulations reproduce experimental measurements suggesting that cholesterol prefers to be solvated by saturated acyl chains and has a low affinity for polyunsaturated fatty acids. Analyses of the simulation trajectory provide a detailed picture of both the transverse and lateral structures of the lipid bilayer membrane, along with a description of lipid and cholesterol dynamics at high temporal resolution. Comparison with a previous simulation of a pure phospholipid bilayer allows an atomic-level description of the changes in membrane structure and dynamics resulting from incorporation of cholesterol. The observed differential cholesterol interactions with saturated and polyunsaturated lipids provide a mechanism for the formation of laterally inhomogeneous membranes; thus, the simulation provides molecular-level insight into the formation of lipid rafts.
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Citations
Cites
Molecular organization of cholesterol in polyunsaturated membranes: microdomain formation
Brzustowicz, M. R., Cherezov, V., Caffrey, M., Stillwell, W., & Wassall, S. R. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)75394-0 · Cited by 161
Cited by
Polyunsaturated fatty acid–cholesterol interactions: Domain formation in membranes
Wassall, S. R., & Stillwell, W. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.10.011 · Cited by 292
Molecular View of Cholesterol Flip-Flop and Chemical Potential in Different Membrane Environments
Bennett, W. F. D., MacCallum, J. L., Hinner, M. J., Marrink, S. J., & Tieleman, D. P. (2009) · Journal of the American Chemical Society · doi:10.1021/ja903529f · Cited by 279
Kučerka, N., Marquardt, D., Harroun, T. A., Nieh, M.-P., Wassall, S. R., de Jong, D. H., Schäfer, L. V., Marrink, S. J., & Katsaras, J. (2010) · Biochemistry · doi:10.1021/bi100891z · Cited by 112
Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol
Murcia, M., Faráldo-Gómez, J. D., Maxfield, F. R., & Roux, B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600232-jlr200 · Cited by 111
Metadata
- Authors
- Pitman, M. C., Suits, F., MacKerell, A. D., & Feller, S. E.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-11-12
- Volume
- 43
- Issue
- 49
- Pages
- 15318-15328
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2073059665
- Cited by
- 176
- References
- 1
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
