Cited by 77Lipid Membrane Structure and BehaviorOrigins and Evolution of LifeLipid metabolism and biosynthesis

Stability of Heterochiral Hybrid Membrane Made of Bacterial sn-G3P Lipids and Archaeal sn-G1P Lipids

Shimada, Haruo, Yamagishi, Akihiko·2011·Biochemistry

Abstract

The structure of membrane lipids in Archaea is different from those of Bacteria and Eucarya in many ways including the chirality of the glycerol backbone. Until now, heterochiral membranes were believed to be unstable; thus, no cellular organism could have existed before the separation of the groups of life. In this study, we tested the formation of heterochiral hybrid membrane made of Bacterial sn-glycerol-3-phosphate-type polar lipid and Archaeal sn-glycerol-1-phosphate-type polar lipid using the fluorescence probe. The stability of the hybrid liposomes made of phosphatidylethanolamines or phosphatidylcholines or polar lipids of thermophilic Bacteria and polar lipids of Archaea were investigated. The hybrid liposomes are all stable compared with homochiral liposome made of dimyristoylphosphatidylethanolamine and dipalmitoylphosphatidylcholine. However, the stability was drastically changed with increasing carbon chain length. Accordingly, "chirality" may not be but chain length is important. From these results, we suggest that the heterochiral hybrid membrane could be used as the membrane lipid for the last universal common ancestor (Commonote) before the emergence of Archaea and Bacteria.

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Crossref · 10.1021/bi200172d

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  • A Domain level takeover event is at least biophysically plausible.

    “Consistent with this, recent work suggests that a Bhybrid^membrane of both bacterial-and archaeal-type lipids is stable and could have been used by LUCA, and thus a Domain level takeover event is at least biophysically plausible (Shimada and Yamagishi 2011).”

    From Environmental Adaptation from the Origin of Life to the Last Universal Common Ancestor (2018) · cites this paper as Shimada and Yamagishi 2011

  • A hybrid membrane of both bacterial- and archaeal-type lipids is stable and could have been used by LUCA.

    “Consistent with this, recent work suggests that a Bhybrid^membrane of both bacterial-and archaeal-type lipids is stable and could have been used by LUCA, and thus a Domain level takeover event is at least biophysically plausible (Shimada and Yamagishi 2011).”

    From Environmental Adaptation from the Origin of Life to the Last Universal Common Ancestor (2018) · cites this paper as Shimada and Yamagishi 2011

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Authors
Shimada, H., & Yamagishi, A.
Affiliations
Tokyo University of Pharmacy and Life Sciences (JP)
Corresponding author
Yamagishi, Akihiko
Venue
Biochemistry
Published
2011-04-20
Volume
50
Issue
19
Pages
4114-4120
ISSN
  • 0006-2960 (ISSN-L)
  • 1520-4995
OpenAlex
W2145601109
Cited by
77
References
40
Citations by year
2026: 4 · 2025: 2 · 2024: 11 · 2023: 9 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 9 · 2013: 1 · 2012: 2
FWCI
1.68
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
  • Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
carbon chain length, last universal common ancestor, origin of life, thermophilic bacteria, archaea
MeSH terms
Glycerophosphates, Liposomes, Membrane Lipids, Phosphatidylethanolamines, Stereoisomerism, 1,2-Dipalmitoylphosphatidylcholine, Sulfolobus, Thermus thermophilus, Aeropyrum

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