Stability of Heterochiral Hybrid Membrane Made of Bacterial sn-G3P Lipids and Archaeal sn-G1P Lipids
Abstract
The structure of membrane lipids in Archaea is different from those of Bacteria and Eucarya in many ways including the chirality of the glycerol backbone. Until now, heterochiral membranes were believed to be unstable; thus, no cellular organism could have existed before the separation of the groups of life. In this study, we tested the formation of heterochiral hybrid membrane made of Bacterial sn-glycerol-3-phosphate-type polar lipid and Archaeal sn-glycerol-1-phosphate-type polar lipid using the fluorescence probe. The stability of the hybrid liposomes made of phosphatidylethanolamines or phosphatidylcholines or polar lipids of thermophilic Bacteria and polar lipids of Archaea were investigated. The hybrid liposomes are all stable compared with homochiral liposome made of dimyristoylphosphatidylethanolamine and dipalmitoylphosphatidylcholine. However, the stability was drastically changed with increasing carbon chain length. Accordingly, "chirality" may not be but chain length is important. From these results, we suggest that the heterochiral hybrid membrane could be used as the membrane lipid for the last universal common ancestor (Commonote) before the emergence of Archaea and Bacteria.
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A Domain level takeover event is at least biophysically plausible.
“Consistent with this, recent work suggests that a Bhybrid^membrane of both bacterial-and archaeal-type lipids is stable and could have been used by LUCA, and thus a Domain level takeover event is at least biophysically plausible (Shimada and Yamagishi 2011).”
From Environmental Adaptation from the Origin of Life to the Last Universal Common Ancestor (2018) · cites this paper as Shimada and Yamagishi 2011
A hybrid membrane of both bacterial- and archaeal-type lipids is stable and could have been used by LUCA.
“Consistent with this, recent work suggests that a Bhybrid^membrane of both bacterial-and archaeal-type lipids is stable and could have been used by LUCA, and thus a Domain level takeover event is at least biophysically plausible (Shimada and Yamagishi 2011).”
From Environmental Adaptation from the Origin of Life to the Last Universal Common Ancestor (2018) · cites this paper as Shimada and Yamagishi 2011
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- Authors
- Shimada, H., & Yamagishi, A.
- Affiliations
- Tokyo University of Pharmacy and Life Sciences (JP)
- Corresponding author
- Yamagishi, Akihiko
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-04-20
- Volume
- 50
- Issue
- 19
- Pages
- 4114-4120
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2145601109
- Cited by
- 77
- References
- 40
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 11 · 2023: 9 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 9 · 2013: 1 · 2012: 2
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- carbon chain length, last universal common ancestor, origin of life, thermophilic bacteria, archaea
- MeSH terms
- Glycerophosphates, Liposomes, Membrane Lipids, Phosphatidylethanolamines, Stereoisomerism, 1,2-Dipalmitoylphosphatidylcholine, Sulfolobus, Thermus thermophilus, Aeropyrum
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