The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Requirement for Natively Unstructured Regions of Mesoderm Development Candidate 2 in Promoting Low-Density Lipoprotein Receptor-Related Protein 6 Maturation
Abstract
Proteins of the low-density lipoprotein receptor family (LRPs) are complex, multimodular type I transmembrane receptors. Productive maturation of these proteins relies on an ER-resident protein called mesoderm development candidate 2 (MESD) in mammals and Boca in Drosophila. We show here that MESD contains a central folded domain flanked by natively unstructured regions required to facilitate maturation of LRP6. Enforced expression of full-length human MESD promotes the secretion of soluble minireceptors derived from LRP6 that contain either one or two beta-propeller-EGF domain pairs. Conversely, siRNA-mediated knockdown of human MESD expression blocks secretion of native LRP6 minireceptors and dramatically reduces the level of cell-surface expression of full-length LRP6. Cell-surface expression is only rescued by simultaneous delivery of siRNA-resistant forms of mouse MESD that contain most or all of the unstructured N- and C-termini, implicating the flexible parts of MESD in its function of promoting LRP maturation.
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Boca/Mesd is specifically required for maturation of the LDLR family beta-propeller/EGF modules.
“Boca/mesd is specifically required for maturation of the LDLR family beta-propeller/EGF modules,53−55”
Citations
Cites
Mesd Encodes an LRP5/6 Chaperone Essential for Specification of Mouse Embryonic Polarity
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Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
Li, Y., Chen, J., Lu, W., McCormick, L. M., Wang, J., & Bu, G. (2005) · Journal of Cell Science · doi:10.1242/jcs.02651 · Cited by 53
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- Abbreviations APC, ademnoatous polyposis coli
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Weekes, M. P., Antrobus, R., Talbot, S., Hör, S., Simecek, N., Smith, D. L., Bloor, S., Randow, F., & Lehner, P. J. (2012) · Journal of Proteome Research · doi:10.1021/pr201135e · Cited by 82
Metadata
- Authors
- Koduri, V., & Blacklow, S. C.
- Affiliations
- Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-05-09
- Volume
- 46
- Issue
- 22
- Pages
- 6570-6577
- ISSN
- 0006-2960
- 1520-4995
- Cited by
- 25
- References
- 3
- Language
- en
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