The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.
Mesd Encodes an LRP5/6 Chaperone Essential for Specification of Mouse Embryonic Polarity
Open accessAbstract
Specification of embryonic polarity and pattern formation in multicellular organisms requires inductive signals from neighboring cells. One approach toward understanding these interactions is to study mutations that disrupt development. Here, we demonstrate that mesd, a gene identified in the mesoderm development (mesd) deletion interval on mouse chromosome 7, is essential for specification of embryonic polarity and mesoderm induction. MESD functions in the endoplasmic reticulum as a specific chaperone for LRP5 and LRP6, which in conjunction with Frizzled, are coreceptors for canonical WNT signal transduction. Disruption of embryonic polarity and mesoderm differentiation in mesd-deficient embryos likely results from a primary defect in WNT signaling. However, phenotypic differences between mesd-deficient and wnt3(-)(/)(-) embryos suggest that MESD may function on related members of the low-density lipoprotein receptor (LDLR) family, whose members mediate diverse cellular processes ranging from cargo transport to signaling.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“More recently, two groups have identified a novel specialized chaperone for members of the LDLR family, termed Mesd (mesoderm development) in mouse (Hsieh et al., 2003) and Boca in Drosophila (Culi and Mann, 2003).”
From Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding (2005) · cites this paper as Hsieh et al., 2003
In the citing paper
“LDLR family members also have a specific requirement for the molecular ER chaperone boca (Drosophila melanogaster), and its mammlian orthologue Mesd, for folding and trafficking to the cell surface.50−52”
Citations
Cites
Site-directed mutagenesis by overlap extension using the polymerase chain reaction
Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., & Pease, L. R. (1989) · Gene · doi:10.1016/0378-1119(89)90358-2 · Cited by 7,354
Predicting subcellular localization of proteins based on their N-terminal amino acid sequence.
Emanuelsson, O., Nielsen, H., Brunak, S., & von Heijne, G. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3903 · Cited by 4,419
Nakai, K., & Horton, P. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01336-x · Cited by 2,181
A C-terminal signal prevents secretion of luminal ER proteins
Munro, S., & Pelham, H. R. B. (1987) · Cell · doi:10.1016/0092-8674(87)90086-9 · Cited by 1,721
An LDL-receptor-related protein mediates Wnt signalling in mice
Pinson, K. I., Brennan, J., Monkley, S. J., Avery, B. J., & Skarnes, W. C. (2000) · Nature · doi:10.1038/35035124 · Cited by 1,086
Molecular genetics of the LDL receptor gene in familial hypercholesterolemia
Hobbs, H. H., Brown, M. S., & Goldstein, J. L. (1992) · Human Mutation · doi:10.1002/humu.1380010602 · Cited by 921
Requirement for Wnt3 in vertebrate axis formation
Liu, P., Wakamiya, M., Shea, M. J., Albrecht, U., Behringer, R. R., & Bradley, A. (1999) · Nature Genetics · doi:10.1038/11932 · Cited by 900
Conlon, F. L., Lyons, K. M., Takaesu, N. T., Barth, K. S., Kispert, A., Herrmann, B. G., & Robertson, E. J. (1994) · Development · doi:10.1242/dev.120.7.1919 · Cited by 772
Axis Development and Early Asymmetry in Mammals
Beddington, R. S. P., & Robertson, E. J. (1999) · Cell · doi:10.1016/s0092-8674(00)80560-7 · Cited by 746
Mouse gastrulation: the formation of a mammalian body plan
Tam, P., & Behringer, R. R. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00123-8 · Cited by 594
Flagged first, then by citations
1 of the 39 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Hogan, B., Beddington, R., Costantini, F., and Lacy, E. (1994). Manipulating the Mouse Embryo: A Laboratory Manual, Volume 1, Second Edition (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press).
Cited by
Sorted by citations
Wnt/β-Catenin Signaling in Development and Disease
Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325
Wnt signalling and its impact on development and cancer
Klaus, A., & Birchmeier, W. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2389 · Cited by 1,595
LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
He, X., Semenov, M., Tamai, K., & Zeng, X. (2004) · Development · doi:10.1242/dev.01117 · Cited by 1,044
Bänziger, C., Soldini, D., Schütt, C., Zipperlen, P., Hausmann, G., & Basler, K. (2006) · Cell · doi:10.1016/j.cell.2006.02.049 · Cited by 764
Metadata
- Authors
- Hsieh, J.-C., Lee, L., Zhang, L., Wefer, S., Brown, K., DeRossi, C., Wines, M. E., Rosenquist, T., & Holdener, B. C.
- Affiliations
- Stony Brook University (US)
- Corresponding author
- Holdener, Bernadette C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 112
- Issue
- 3
- Pages
- 355-367
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2052749020
- Cited by
- 237
- References
- 39
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 10 · 2021: 9 · 2020: 5 · 2019: 8 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 5 · 2014: 14 · 2013: 13 · 2012: 18
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM053964)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD53964)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Oncology › Renal and related cancers
- Keywords
- LRP5, LRP6, molecular chaperones, embryonic polarity, mesoderm induction, Wnt/β-catenin signaling, Frizzled receptors, endoplasmic reticulum, mesoderm differentiation, Wnt3, low-density lipoprotein receptor family, mouse embryo
- MeSH terms
- Congenital Abnormalities, Animals, Cell Differentiation, Embryo, Mammalian, Endoplasmic Reticulum, Female, Genes, Lethal, Male, Mesoderm, Mutation, Phenotype, Proteins, Receptors, LDL, Signal Transduction, Cell Polarity, Mice, Knockout, Molecular Chaperones, Body Patterning, COS Cells, LDL-Receptor Related Proteins, Wnt Proteins, Mice, Low Density Lipoprotein Receptor-Related Protein-6, Low Density Lipoprotein Receptor-Related Protein-5, Wnt3 Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
