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Cited by 268

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Diverse Cell Signaling Events Modulated by Perlecan

Open access
Whitelock, John M., Melrose, James, Iozzo, Renato V.·2008·Biochemistry
DOI 10.1021/bi8013938
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Abstract

Perlecan is a ubiquitous pericellular proteoglycan ideally placed to mediate cell signaling events controlling migration, proliferation, and differentiation. Its control of growth factor signaling usually involves interactions with the heparan sulfate chains covalently coupled to the protein core's N-terminus. However, this modular protein core also binds with relatively high affinity to a number of growth factors and surface receptors, thereby stabilizing cell-matrix links. This review will focus on perlecan-growth factor interactions and describe recent advances in our understanding of this highly conserved proteoglycan during development, cancer growth, and angiogenesis. The pro-angiogenic capacities of perlecan that involve proliferative and migratory signals in response to bound growth factors will be explored, as well as the anti-angiogenic signals resulting from interactions between the C-terminal domain known as endorepellin and integrins that control adhesion of cells to the extracellular matrix. These two somewhat diametrically opposed roles will be discussed in light of new data emerging from various fields which converge on perlecan as a key regulator of cell growth and angiogenesis.

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Metadata

Authors
Whitelock, J. M., Melrose, J., & Iozzo, R. V.
Venue
Biochemistry
Publisher
American Chemical Society (ACS)
Published
2008-10-01
Volume
47
Issue
43
Pages
11174-11183
ISSN
  • 0006-2960 (ISSN-L)
  • 1520-4995
DOI
10.1021/bi8013938
OpenAlex
W2015724236
Cited by
268
References
59
FWCI
6.70
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Diverse Cell Signaling Events Modulated by Perlecan. https://app.cochat.ai/papers/10.1021/bi8013938
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Whitelock, J. M., Melrose, J., & Iozzo, R. V. (2008). Diverse Cell Signaling Events Modulated by Perlecan. Biochemistry. https://doi.org/10.1021/bi8013938

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