The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Chromium Oligopeptide Activates Insulin Receptor Tyrosine Kinase Activity
Abstract
A possible new mechanism for the amplification of insulin receptor tyrosine kinase activity in response to insulin has been identified. The chromium-containing oligopeptide low molecular weight chromium-binding substance (LMWCr) does not effect the tyrosine protein kinase activity of rat adipocytic membrane fragments in the absence of insulin; however, insulin-stimulated kinase activity in the membrane fragments is increased up to 8-fold by the oligopeptide. Using isolated rat insulin receptor, LMWCr has been shown to bind to insulin-activated insulin receptor with a dissociation constant of circa 250 pM, resulting in the increase of its tyrosine protein kinase activity. The ability of LMWCr to stimulate insulin receptor tyrosine kinase activity is dependent on its chromium content. The results appear to explain the previously poorly understood relationship between chromium and adult-onset diabetes and cardiovascular disease.
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Cites
Spectrophotometric determination of elements
Steyermark, A. (1977) · Microchemical Journal · doi:10.1016/0026-265x(77)90041-8 · Cited by 775
Isolation of a biologically active low-molecular-mass chromium compound from rabbit liver
Yamamoto, A., Wada, O., & Ono, T. (1987) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1987.tb11486.x · Cited by 117
Purification and Properties of Biologically Active Chromium Complex from Bovine Colostrum
Yamamoto, A., Wada, O., & Suzuki, H. (1988) · Journal of Nutrition · doi:10.1093/jn/118.1.39 · Cited by 75
Morris, B. W., MacNeil, S., Stanley, K., Gray, T. A., & Fraser, R. (1993) · Journal of Endocrinology · doi:10.1677/joe.0.1390339 · Cited by 62
The trace element chromium—a role in glucose homeostasis
Morris, B., Blumsohn, A., Neil, S. M., & Gray, T. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/55.5.989 · Cited by 60
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Trace element risk assessment: essentiality vs. toxicity
Goldhaber, S. B. (2003) · Regulatory Toxicology and Pharmacology · doi:10.1016/s0273-2300(02)00020-x · Cited by 802
Glycemic index and heart disease,,
Leeds, A. R. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.1.286s · Cited by 99
Pharmacological approaches to the management of binge eating disorder
Brownley, K. A., Peat, C. M., La Via, M., & Bulik, C. M. (2015) · Drugs · doi:10.1007/s40265-014-0327-0 · Cited by 78
Mechanick, J. I., Brett, E. M., Chausmer, A. B., Dickey, R. A., Wallach, S., Bergman, D. A., Garber, J. R., Hamilton, C. R., Handelsman, Y., Holdy, K. E., et al. (2003) · Endocrine Practice · doi:10.4158/ep.9.5.417 · Cited by 73
Mineral Micronutrients in Asthma
Zajac, D. (2021) · Nutrients · doi:10.3390/nu13114001 · Cited by 33
Metadata
- Authors
- Davis, C. M., & Vincent, J. B.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1997-04-01
- Volume
- 36
- Issue
- 15
- Pages
- 4382-4385
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W1972656394
- Cited by
- 279
- References
- 5
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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