Cited by 33Asthma and respiratory diseasesTrace Elements in HealthMagnesium in Health and Disease

Mineral Micronutrients in Asthma

Open access
Zajac, Dominika·2021·Nutrients

Abstract

Asthma represents one of the most common medical issues in the modern world. It is a chronic inflammatory disease characterized by persistent inflammation of the airways and disturbances in redox status, leading to hyperresponsiveness of bronchi and airway obstruction. Apart from classical risk factors such as air pollution, family history, allergies, or obesity, disturbances of the levels of micronutrients lead to impairments in the defense mechanisms of the affected organism against oxidative stress and proinflammatory stimuli. In the present review, the impact of micronutrients on the prevalence, severity, and possible risk factors of asthma is discussed. Although the influence of classical micronutrients such as selenium, copper, or zinc are well known, the effects of those such as iodine or manganese are only rarely mentioned. As a consequence, the aim of this paper is to demonstrate how disturbances in the levels of micronutrients and their supplementation might affect the course of asthma.

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Crossref · 10.3390/nu13114001

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  • Manganese supplementation might improve antioxidant functions in the lungs and ameliorate asthma conditions.

    “Despite some controversial data arise, other findings point out that Mn supplementation might improve antioxidant functions in the lungs and ameliorate asthma conditions, as reported in a recent review [449].”
  • Manganese and copper are involved in antioxidant mechanisms through their structural role within SOD and other enzymes protecting cells from oxidative stress.

    “Manganese and copper are further trace elements involved in antioxidant mechanisms through their structural role within SOD and other crucial enzymes useful for protecting cells from OS [447,448,449].”

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  1. [176]Bai Y. Hunt C.D. Newman S.M. Dietary boron increases serum antibody (IgG and IgM) concentrations in rats immunized with human typhoid vaccine Proc. North Dakota Acad. Sci. 1997 51 81

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Authors
Zajac, D.
Affiliations
Department of Respiration Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, ul. Pawinskiego 5, 02-106 Warsaw, Poland
Venue
Nutrients
Publisher
MDPI AG
Published
2021-11-10
Volume
13
Issue
11
Pages
4001
ISSN
2072-6643 (ISSN-L)
OpenAlex
W3214341568
Cited by
33
References
192
Citations by year
2026: 6 · 2025: 8 · 2024: 9 · 2023: 5 · 2022: 5
FWCI
0.63
Type
journal article
Language
en
Open access
Locations
  • Nutrients (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
Keywords
asthma, micronutrients, oxidative stress, selenium, copper, zinc, iodine, manganese, micronutrient supplementation, airway inflammation, airway hyperresponsiveness, asthma risk factors
MeSH terms
Asthma, Bronchi, Copper, Humans, Hypersensitivity, Immunity, Inflammation, Manganese, Obesity, Risk Factors, Selenium, Zinc, Oxidative Stress, Micronutrients, Dietary Supplements

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