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Comparative Mammalian Cell Toxicity of N-DBPs and C-DBPs
Abstract
In order to generate a quantitative, direct comparison amongst classes of drinking water disinfection by-products (DBPs), we developed and calibrated in vitro mammalian cell cytotoxicity and genotoxicity assays to integrate the analytical biology with the analytical chemistry of these important environmental contaminants. The generated database demonstrates the universality of the comparative toxicity of iodo- > bromo- » chloro-DBPs across different structural DBP classes and the substantially greater toxicity of nitrogen-containing DBPs (NDBPs) compared to carbonaceous DBPs (C-DBPs). These results are important in light of the generation of iodinated-DBPs and N-DBPs that may result from the use of alternative disinfectants.
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Cited by
RICHARDSON, S., PLEWA, M., WAGNER, E., SCHOENY, R., & DEMARINI, D. (2007) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2007.09.001 · Cited by 3,317
Self-citationRichardson, S. D., DeMarini, D. M., Kogevinas, M., Fernandez, P., Marco, E., Lourencetti, C., Ballesté, C., Heederik, D., Meliefste, K., McKague, A. B., et al. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.1001965 · Cited by 327
Self-citationVillanueva, C. M., Kogevinas, M., Cordier, S., Templeton, M. R., Vermeulen, R., Nuckols, J. R., Nieuwenhuijsen, M. J., & Levallois, P. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1206229 · Cited by 256
Trihalomethanes in Drinking Water and Bladder Cancer Burden in the European Union
Evlampidou, I., Font-Ribera, L., Rojas-Rueda, D., Gracia-Lavedan, E., Costet, N., Pearce, N., Vineis, P., Jaakkola, J. J. K., Delloye, F., Makris, K. C., et al. (2020) · Environmental Health Perspectives · doi:10.1289/ehp4495 · Cited by 178
Volatile disinfection by-product analysis from chlorinated indoor swimming pools
Weaver, W. A., Li, J., Wen, Y., Johnston, J., Blatchley, M. R., & Blatchley III, E. R. (2009) · Water Research · doi:10.1016/j.watres.2009.04.035 · Cited by 172
Metadata
- Authors
- Plewa, M. J., Wagner, E. D., Muellner, M. G., Hsu, K.-M., & Richardson, S. D.
- Venue
- ACS Symposium Series
- Publisher
- American Chemical Society
- Published
- 2008-08-05
- Pages
- 36-50
- ISSN
- 0097-6156 (ISSN-L)
- 1947-5918
- OpenAlex
- W156330715
- Cited by
- 310
- References
- 0
- FWCI
- 93.12
- Type
- conference paper
- Language
- en
- Open access
- closed
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- Plewa, M. J., Wagner, E. D., Muellner, M. G., Hsu, K.-M., & Richardson, S. D. (2008). Comparative Mammalian Cell Toxicity of N-DBPs and C-DBPs. ACS Symposium Series. https://doi.org/10.1021/bk-2008-0995.ch003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.