The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Preparation of Nanoparticles Composed of Chitosan/Poly-γ-glutamic Acid and Evaluation of Their Permeability through Caco-2 Cells
Abstract
In this study, a novel nanoparticle system for paracellular transport was prepared using a simple and mild ionic-gelation method upon addition of a poly-gamma-glutamic acid (gamma-PGA) solution into a low-molecular-weight chitosan (low-MW CS) solution. The particle size and the zeta potential value of the prepared nanoparticles can be controlled by their constituted compositions. The results obtained by the TEM and AFM examinations showed that the morphology of the prepared nanoparticles was spherical in shape. Evaluation of the prepared nanoparticles in enhancing intestinal paracellular transport was investigated in vitro in Caco-2 cell monolayers. It was found that the nanoparticles with CS dominated on the surfaces could effectively reduce the transepithelial electrical resistance (TEER) of Caco-2 cell monolayers. After removal of the incubated nanoparticles, a gradual increase in TEER was noticed. The confocal laser scanning microscopy observations confirmed that the nanoparticles with CS dominated on the surface were able to open the tight junctions between Caco-2 cells and allowed transport of the nanoparticles via the paracellular pathways.
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Cites
Hidalgo, I. J., Raub, T. J., & Borchardt, R. T. (1989) · Gastroenterology · doi:10.1016/s0016-5085(89)80072-1 · Cited by 2,396
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Mishra, B., Patel, B. B., & Tiwari, S. (2010) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2009.04.008 · Cited by 771
Targeted nanoparticles for drug delivery through the blood–brain barrier for Alzheimer's disease
Roney, C., Kulkarni, P., Arora, V., Antich, P., Bonte, F., Wu, A., Mallikarjuana, N. N., Manohar, S., Liang, H.-F., Kulkarni, A. R., et al. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.07.024 · Cited by 406
Self-citationIn vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery
Sonaje, K., Lin, Y.-H., Juang, J.-H., Wey, S.-P., Chen, C.-T., & Sung, H.-W. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.066 · Cited by 295
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Metadata
- Authors
- Lin, Y.-H., Chung, C.-K., Chen, C.-T., Liang, H.-F., Chen, S.-C., & Sung, H.-W.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-01-22
- Volume
- 6
- Issue
- 2
- Pages
- 1104-1112
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2024299064
- Cited by
- 200
- References
- 1
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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