Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
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Caco-2/Tc7 cells have a small intestinal phenotype.
“with a small intestinal phenotype [21]”
From Characterization of Vibrio cholerae neuraminidase as an immunomodulator for novel formulation of oral allergy immunotherapy (2018) · cites this paper as [21]
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“…is a suitable model for TER assays, because Caco-2 cells undergo enterocytic differentiation as well as express intercellular junctional complexes and, therefore, changes in TER can be measured as a response to external stimuli (Hidalgo et al., 1989; Klingberg et al., 2005; Hsieh et al., 2015).”
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- Authors
- Hidalgo, I. J., Raub, T. J., & Borchardt, R. T.
- Affiliations
- University of Kansas (US)
- ORCID
- Hidalgo, Ismael J.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1989-02
- Volume
- 96
- Issue
- 2
- Pages
- 736-749
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1904678284
- Cited by
- 2,396
- References
- 52
- Citations by year
- 2026: 48 · 2025: 78 · 2024: 70 · 2023: 71 · 2022: 71 · 2021: 94 · 2020: 114 · 2019: 93 · 2018: 101 · 2017: 75 · 2016: 85 · 2015: 80 · 2014: 82 · 2013: 99 · 2012: 82
- FWCI
- 12.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- Caco-2 cells, intestinal epithelial permeability, enterocyte differentiation, transepithelial electrical resistance, intestinal barrier function, horseradish peroxidase uptake, small intestinal epithelium, cell monolayers
- MeSH terms
- Adenocarcinoma, Biological Transport, Cell Line, Cell Membrane Permeability, Colonic Neoplasms, Culture Media, Electric Conductivity, Gastrointestinal Motility, Horseradish Peroxidase, Humans, Intestinal Absorption, Membranes, Artificial, Tumor Cells, Cultured, In Vitro Techniques
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