Synthesis and characterization of biocompatible thermo-responsive gelators based on aba triblock copolymers
Abstract
The synthesis of biocompatible, thermo-responsive ABA triblock copolymers in which the outer A blocks comprise poly(N-isopropylacrylamide) and the central B block is poly(2-methacryloyloxyethyl phosphorylcholine) is achieved using atom transfer radical polymerization with a commercially available bifunctional initiator. These novel triblock copolymers are water-soluble in dilute aqueous solution at 20 degrees C and pH 7.4 but form free-standing physical gels at 37 degrees C due to hydrophobic interactions between the poly(N-isopropylacrylamide) blocks. This gelation is reversible, and the gels are believed to contain nanosized micellar domains; this suggests possible applications in drug delivery and tissue engineering.
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A series of biocompatible, thermo-responsive ABA triblock copolymers comprising PNIPAM as the A block and PMPC as the central B block was synthesized using ATRP initiated by a difunctional initiator.
“For example, a series of biocompatible, thermo-responsive ABA triblock copolymers comprising poly(N-isopropyl acrylamide) (PNIPAM) as the A block and poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) as the central B block was synthesized using ATRP initiated by a difunctional initiator, as illustrated in Scheme 1 [23].”
From Block Copolymers: Synthesis, Self-Assembly, and Applications (2017) · cites this paper as [23]
Cites
Solution Properties of Poly(N-isopropylacrylamide)
Heskins, M., & Guillet, J. E. (1968) · Journal of Macromolecular Science Part A - Chemistry · doi:10.1080/10601326808051910 · Cited by 3,121 · see citing works
Comb-type grafted hydrogels with rapid deswelling response to temperature changes
Yoshida, R., Uchida, K., Kaneko, Y., Sakai, K., Kikuchi, A., Sakurai, Y., & Okano, T. (1995) · Nature · doi:10.1038/374240a0 · Cited by 1,257 · see citing works
Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH
Chen, G., & Hoffman, A. S. (1995) · Nature · doi:10.1038/373049a0 · Cited by 1,221 · see citing works
Preparation of Phospholipid Polylners and Their Properties as Polymer Hydrogel Membranes
Ishihara, K., Ueda, T., & Nakabayashi, N. (1990) · Polymer Journal · doi:10.1295/polymj.22.355 · Cited by 1,077 · see citing works
Thermo‐responsive polymeric surfaces; control of attachment and detachment of cultured cells
Yamada, N., Okano, T., Sakai, H., et al. (1990) · Die Makromolekulare Chemie Rapid Communications · doi:10.1002/marc.1990.030111109 · Cited by 984 · see citing works
Responsive Hydrogels from the Intramolecular Folding and Self-Assembly of a Designed Peptide
Schneider, J. P., Pochan, D. J., Ozbas, B., Rajagopal, K., Pakstis, L., & Kretsinger, J. K. (2002) · Journal of the American Chemical Society · doi:10.1021/ja027993g · Cited by 947 · see citing works
Globule-to-Coil Transition of a Single Homopolymer Chain in Solution
Wu, C., & Wang, X. (1998) · Physical Review Letters · doi:10.1103/physrevlett.80.4092 · Cited by 635 · see citing works
Volume transition in a gel driven by hydrogen bonding
Ilmain, F., Tanaka, T., & Kokufuta, E. (1991) · Nature · doi:10.1038/349400a0 · Cited by 509 · see citing works
Phosphorylcholine-based polymers and their use in the prevention of biofouling
Lewis, A. L. (2000) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(99)00152-6 · Cited by 497 · see citing works
Self-citationPochan, D. J., Schneider, J. P., Kretsinger, J. K., Ozbas, B., Rajagopal, K., & Haines-Butterick, L. A. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0353154 · Cited by 463 · see citing works
Biomembrane surfaces as models for polymer design: the potential for haemocompatibility
Hayward, J. A., & Chapman, D. (1984) · Biomaterials · doi:10.1016/0142-9612(84)90047-4 · Cited by 393 · see citing works
Stimulus-Responsive Water-Soluble Polymers Based on 2-Hydroxyethyl Methacrylate
Weaver, J. V. M., Bannister, I., Robinson, K. L., Bories-Azeau, X., Armes, S. P., Smallridge, M. J., & McKenna, P. (2004) · Macromolecules · doi:10.1021/ma0356358 · Cited by 273 · see citing works
Self-citationLi, C., Gunari, N., Fischer, K., et al. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200352845 · Cited by 208 · see citing works
Self-citationMicellisation and gelation of triblock copoly(oxyethylene/oxypropylene/oxyethylene), F127
Yu, G., Deng, Y., Dalton, S., et al. (1992) · Journal of the Chemical Society Faraday Transactions · doi:10.1039/ft9928802537 · Cited by 200 · see citing works
Gutowska, A., Bae, Y. H., Jacobs, H. A., et al. (1994) · Macromolecules · doi:10.1021/ma00093a018 · Cited by 180 · see citing works
Iris, Y., Lobb, E. J., Billingham, N. Ć., Armes, S. P., Lewis, A. L., Lloyd, A. W., & Salvage, J. P. (2002) · Macromolecules · doi:10.1021/ma0210325 · Cited by 167 · see citing works
Self-citationSynthesis of Biocompatible, Stimuli-Responsive, Physical Gels Based on ABA Triblock Copolymers
Ma, Y., Tang, Y., Billingham, N. Ć., Armes, S. P., & Lewis, A. L. (2003) · Biomacromolecules · doi:10.1021/bm034118u · Cited by 144 · see citing works
Self-citationPreparation of non-thrombogenic materials using 2-methacryloyloxyethyl phosphorylcholine
Nakabayashi, N., & Williams, D. F. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00113-3 · Cited by 138 · see citing works
Yang, Z. L., Pickard, S., Deng, N., Barlow, R. J., Attwood, D., & Booth, C. (1994) · Macromolecules · doi:10.1021/ma00087a002 · Cited by 138 · see citing works
Robinson, K. L., Weaver, J. V. M., Armes, S. P., Díaz-Martí, E., & Meldrum, F. C. (2002) · Journal of Materials Chemistry · doi:10.1039/b200348c · Cited by 78 · see citing works
Self-citationHydrogen-bonded polymer gel and its application as a temperature-sensitive drug delivery system
Oh, K. S., Han, S. K., Choi, Y. W., et al. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.09.008 · Cited by 73 · see citing works
Modification of heat resistance in Drosophila by selection
Morrison, W. W., & Milkman, R. (1978) · Nature · doi:10.1038/273049b0 · Cited by 71 · see citing works
Polymeric microspheres composed of pH/temperature-sensitive polymer complex
Kim, E. J., Cho, S. H., & Yuk, S. H. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00439-7 · Cited by 71 · see citing works
Castelletto, V., Hamley, I. W., Ma, Y., Bories-Azeau, X., Armes, S. P., & Lewis, A. L. (2004) · Langmuir · doi:10.1021/la049859a · Cited by 64 · see citing works
Self-citationBerlinova, I. V., Dimitrov, I. V., Vladimirov, N. G., et al. (2001) · Polymer · doi:10.1016/s0032-3861(01)00080-5 · Cited by 56 · see citing works
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Block Copolymers: Synthesis, Self-Assembly, and Applications
Feng, H., Lu, X., Wang, W., Kang, N.-G., & Mays, J. (2017) · Polymers · doi:10.3390/polym9100494 · Cited by 467 · see citing works
“For example, a series of biocompatible, thermo-responsive ABA triblock copolymers comprising poly(N-isopropyl acrylamide) (PNIPAM) as the A block and poly(2methacryloyloxyethyl phosphorylcholine) (PMPC) as the central B block was synthesized using ATRP initiated by a if ctional initiator, as illustrated in Scheme 1 [2…”
MethodResponsive reversible hydrogels from associative “smart” macromolecules
Tsitsilianis, C. (2010) · Soft Matter · doi:10.1039/b923947b · Cited by 278 · see citing works
- Authors
- Li, C., Tang, Y., Armes, S. P., Morris, C. J., Rose, S. F., Lloyd, A. W., & Lewis, A. L.
- Affiliations
- University of Sheffield (GB)
- Biocompatibles (United Kingdom) (GB)
- University of Sussex (GB)
- Corresponding author
- Armes, Steven P.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-01-11
- Volume
- 6
- Issue
- 2
- Pages
- 994-999
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W1997281838
- Cited by
- 166
- References
- 25
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 5 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 7 · 2016: 19 · 2015: 6 · 2014: 11 · 2013: 8 · 2012: 20
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomacromolecules (publishedVersion)
- PubMed (publishedVersion)
- University of Brighton Repository (University of Brighton) (submittedVersion)
- Funders
- Engineering and Physical Sciences Research Council (GR/S25845/01)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- ABA triblock copolymers, thermosensitive hydrogel, poly(N-isopropylacrylamide), poly(2-methacryloyloxyethyl phosphorylcholine), atom transfer radical polymerization, physical gels, hydrophobic interactions, biocompatible polymers, drug delivery, tissue engineering
- MeSH terms
- Acrylic Resins, Biocompatible Materials, Methacrylates, Micelles, Phosphorylcholine, Polymers, Polymethacrylic Acids, Temperature, Hydrogels, Phase Transition, Nanostructures
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