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Elasticity of Native and Cross-Linked Polyelectrolyte Multilayer Films
Abstract
Mechanical properties of polyelectrolyte multilayer films were studied by nanoindentation using the atomic force microscope (AFM). Force-distance measurements using colloidal probe tips were systematically obtained for supported films of poly(L-lysine) and hyaluronan that are suited to bio-application. Both native and covalently cross-linked films were studied as a function of increasing layer number, which increases film thickness. The effective Young's modulus perpendicular to the film, Eperpendicular, was determined to be a function of film thickness, cross-linking, and sample age. Thick PEM films exhibited a lower Eperpendicular than thinner PEM, whereas the Young's modulus of cross-linked films was more than 10-fold larger than native films. Moduli range from approximately 20 kPa for native films up to approximately 800 kPa for cross-linked ones. Young's moduli increased slightly with sample age, plateauing after approximately 4 weeks. Spreading of smooth muscle cells on these substrates with pre-attached collagen proved to be highly dependent on film rigidity with stiffer films giving greater cell spreading.
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Cited by
Soft biological materials and their impact on cell function
Levental, I., Georges, P. C., & Janmey, P. A. (2007) · Soft Matter · doi:10.1039/b610522j · Cited by 905
Internal structure of polyelectrolyte multilayer assemblies
v. Klitzing, R. (2006) · Physical Chemistry Chemical Physics · doi:10.1039/b607760a · Cited by 431
REHFELDT, F., ENGLER, A., ECKHARDT, A., AHMED, F., & DISCHER, D. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.007 · Cited by 405
Self-citationGribova, V., Auzely-Velty, R., & Picart, C. (2012) · Chemistry of Materials · doi:10.1021/cm2032459 · Cited by 338
Self-citationPolyelectrolyte Multilayer Films of Controlled Stiffness Modulate Myoblast Cell Differentiation
Ren, K., Crouzier, T., Roy, C., & Picart, C. (2008) · Advanced Functional Materials · doi:10.1002/adfm.200701297 · Cited by 273
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Metadata
- Authors
- Richert, L., Engler, A. J., Discher, D. E., & Picart, C.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-07-27
- Volume
- 5
- Issue
- 5
- Pages
- 1908-1916
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2086432921
- Cited by
- 247
- References
- 0
- FWCI
- 9.42
- Type
- journal article
- Language
- en
- Open access
- closed
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