The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Sustained Release of Proteins from Electrospun Biodegradable Fibers
Abstract
Electrospinning is a simple and versatile technique of producing polymeric fibers ranging from submicron to micron in diameter. Incorporation of bioactive agents into the fibers could make a biofunctional tissue engineering scaffold. In this study, we investigated the feasibility of encapsulating human beta-nerve growth factor (NGF), which was stabilized in a carrier protein, bovine serum albumin (BSA) in a copolymer of epsilon-caprolactone and ethyl ethylene phosphate (PCLEEP) by electrospinning. Partially aligned protein encapsulated fibers were obtained and the protein was found to be randomly dispersed throughout the electrospun fibrous mesh in aggregate form. A sustained release of NGF via diffusion process was obtained for at least 3 months. PC12 neurite outgrowth assay confirmed that the bioactivity of electrospun NGF was retained, at least partially, throughout the period of sustained release, thus clearly demonstrating the feasibility of encapsulating proteins via electrospinning to produce biofunctional tissue scaffolds.
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Cites
A review on polymer nanofibers by electrospinning and their applications in nanocomposites
Huang, Z.-M., Zhang, Y.-Z., Kotaki, M., & Ramakrishna, S. (2003) · Composites Science and Technology · doi:10.1016/s0266-3538(03)00178-7 · Cited by 7,556
Greene, L. A., & Tischler, A. S. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.7.2424 · Cited by 5,553
Nanometre diameter fibres of polymer, produced by electrospinning
Reneker, D. H., & Chun, I. (1996) · Nanotechnology · doi:10.1088/0957-4484/7/3/009 · Cited by 3,520
Electrospinning of Collagen Nanofibers
Matthews, J. A., Wnek, G. E., Simpson, D. G., & Bowlin, G. L. (2002) · Biomacromolecules · doi:10.1021/bm015533u · Cited by 2,251
A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering
Yoshimoto, H., Shin, Y. M., Terai, H., & Vacanti, J. P. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00635-x · Cited by 1,977
Structure and process relationship of electrospun bioabsorbable nanofiber membranes
Zong, X., Kim, K., Fang, D., Ran, S., Hsiao, B. S., & Chu, B. (2002) · Polymer · doi:10.1016/s0032-3861(02)00275-6 · Cited by 1,893
Physiology of nerve growth factor.
Thoenen, H., & Barde, Y. A. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.4.1284 · Cited by 1,579
Kenawy, E.-R., Bowlin, G. L., Mansfield, K., Layman, J., Simpson, D. G., Sanders, E. H., & Wnek, G. E. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00041-x · Cited by 1,311
Controlling the Fiber Diameter during Electrospinning
Fridrikh, S. V., Yu, J. H., Brenner, M. P., & Rutledge, G. C. (2003) · Physical Review Letters · doi:10.1103/physrevlett.90.144502 · Cited by 941
Encyclopedia Of Controlled Drug Delivery
Mathiowitz, E. (1999) · Medical Entomology and Zoology · Cited by 855
Cited by
Electrospinning: Applications in drug delivery and tissue engineering
Sill, T. J., & von Recum, H. A. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.01.011 · Cited by 3,289
A review on electrospinning design and nanofibre assemblies
Teo, W. E., & Ramakrishna, S. (2006) · Nanotechnology · doi:10.1088/0957-4484/17/14/r01 · Cited by 2,289
Biomimetic materials for tissue engineering
Ma, P. X. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.041 · Cited by 1,310
Three-Dimensional Cell Culture Matrices: State of the Art
Lee, J., Cuddihy, M. J., & Kotov, N. A. (2008) · Tissue Engineering Part B: Reviews · doi:10.1089/teb.2007.0150 · Cited by 1,047
Industrial Upscaling of Electrospinning and Applications of Polymer Nanofibers: A Review
Persano, L., Camposeo, A., Tekmen, C., & Pisignano, D. (2013) · Macromolecular Materials and Engineering · doi:10.1002/mame.201200290 · Cited by 965
Metadata
- Authors
- Chew, S. Y., Wen, J., Yim, E. K. F., & Leong, K. W.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-05-05
- Volume
- 6
- Issue
- 4
- Pages
- 2017-2024
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2013796894
- Cited by
- 584
- References
- 17
- FWCI
- 11.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chew, S. Y., Wen, J., Yim, E. K. F., & Leong, K. W. (2005). Sustained Release of Proteins from Electrospun Biodegradable Fibers. Biomacromolecules. https://doi.org/10.1021/bm0501149
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
