Biodendrimer-Based Hydrogel Scaffolds for Cartilage Tissue Repair
Abstract
Photo-crosslinkable dendritic macromolecules are attractive materials for the preparation of cartilage tissue engineering scaffolds that may be optimized for in situ formation of hydrated, mechanically stable, and well-integrated hydrogel scaffolds supporting chondrocytes and chondrogenesis. We designed and synthesized a novel hydrogel scaffold for cartilage repair, based on a multivalent and water-soluble tri-block copolymer consisting of a poly(ethylene glycol) core and methacrylated poly(glycerol succinic acid) dendrimer terminal blocks. The terminal methacrylates allow mild and biocompatible photo-crosslinking with a visible light, facilitating in vivo filling of irregularly shaped defects with the dendrimer-based scaffold. The multivalent dendrimer constituents allow high crosslink densities that inhibit swelling after crosslinking while simultaneously introducing biodegradation sites. The mechanical properties and water content of the hydrogel can easily be tuned by changing the biodendrimer concentration. In vitro chondrocyte encapsulation studies demonstrate significant synthesis of neocartilaginous material, containing proteoglycans and type II collagen.
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Softer hydrogels have shown more promise for enhancing cell survival and extracellular matrix elaboration due to larger mesh size.
“The softer hydrogels have also shown more promise with enhancing cell survival and extracellular matrix elaboration due to the larger mesh size, making them even more attractive.60–64”
From Student award winner in the undergraduate category for the society of biomaterials 9th World Biomaterials Congress, Chengdu, China, June 1–5, 2012: The effects of substrate stiffness on the <i>in vitro</i> activation of macrophages and <i>in vivo</i> host response to poly(ethylene glycol)‐based hydrogels (2012) · cites this paper as [62]
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Cited by
Sorted by citations
Blakney, A. K., Swartzlander, M. D., & Bryant, S. J. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34104 · Cited by 470 · see citing works
Oliveira, J. M., Salgado, A. J., Sousa, N., Mano, J. F., & Reis, R. L. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.04.006 · Cited by 182 · see citing works
- Authors
- Söntjens, S. H. M., Nettles, D. L., Carnahan, M. A., Setton, L. A., & Grinstaff, M. W.
- Affiliations
- Boston University (US)
- Corresponding author
- Grinstaff, Mark W.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-11-16
- Volume
- 7
- Issue
- 1
- Pages
- 310-316
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2170185723
- Cited by
- 230
- References
- 34
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 13 · 2020: 5 · 2019: 10 · 2018: 12 · 2017: 18 · 2016: 14 · 2015: 16 · 2014: 14 · 2013: 10 · 2012: 9
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomacromolecules (publishedVersion)
- PubMed (publishedVersion)
- TU/e Research Portal (submittedVersion)
- Funders
- National Science Foundation
- Orthopaedic Research and Education Foundation
- National Institutes of Health
- National Institute of Biomedical Imaging and Bioengineering (R01EB002263, EB02263)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Keywords
- hydrogel scaffolds, cartilage tissue engineering, cartilage repair, photocrosslinking, chondrocyte encapsulation, chondrogenesis, proteoglycans, type II collagen, biodegradation, swelling inhibition, mechanical properties
- MeSH terms
- Animals, Biocompatible Materials, Cartilage, Cells, Cultured, Swine, Molecular Structure, Chondrocytes, Hydrogels, Chondrogenesis, Tissue Engineering
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