The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
PEG-SS-PPS: Reduction-Sensitive Disulfide Block Copolymer Vesicles for Intracellular Drug Delivery
Abstract
Under appropriate conditions, block copolymeric macroamphiphiles will self-assemble in water to form vesicles, referred to as polymersomes. We report here polymersomes that can protect biomolecules in the extracellular environment, are taken up by endocytosis, and then suddenly burst within the early endosome, releasing their contents prior to exposure to the harsh conditions encountered after lysosomal fusion. Specifically, block copolymers of the hydrophile poly(ethylene glycol) (PEG) and the hydrophobe poly(propylene sulfide) (PPS) were synthesized with an intervening disulfide, PEG17-SS-PPS30. Polymersomes formed from this block copolymer were demonstrated to disrupt in the presence of intracellular concentrations of cysteine. In cellular experiments, uptake, disruption, and release were observed within 10 min of exposure to cells, well within the time frame of the early endosome of endolysosomal processing. This system may be useful in cytoplasmic delivery of biomolecular drugs such as peptides, proteins, oligonucleotides, and DNA.
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Cites
On the origins of morphological complexity in block copolymer surfactants
Jain, S., & Bates, F. S. (2003) · Science · doi:10.1126/science.1082193 · Cited by 1,217
Discher, D. E., & Ahmed, F. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095838 · Cited by 844
Cited by
Polymers for Drug Delivery Systems
Liechty, W. B., Kryscio, D. R., Slaughter, B. V., & Peppas, N. A. (2010) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-073009-100847 · Cited by 1,608
Blanazs, A., Armes, S. P., & Ryan, A. J. (2009) · Macromolecular Rapid Communications · doi:10.1002/marc.200800713 · Cited by 1,500
New directions in thermoresponsive polymers
Roy, D., Brooks, W. L. A., & Sumerlin, B. S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35499g · Cited by 1,311
Stimuli-Responsive Polymersomes for Programmed Drug Delivery
Meng, F., Zhong, Z., & Feijen, J. (2009) · Biomacromolecules · doi:10.1021/bm801127d · Cited by 1,122
Ge, Z., & Liu, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60048c · Cited by 914
Metadata
- Authors
- Cerritelli, S., Velluto, D., & Hubbell, J. A.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-05-12
- Volume
- 8
- Issue
- 6
- Pages
- 1966-1972
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2057265077
- Cited by
- 443
- References
- 2
- FWCI
- 12.21
- Type
- journal article
- Language
- en
- Open access
- closed
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