Polymers for Drug Delivery Systems

Liechty, William B.; Kryscio, David R.; Slaughter, Brandon V.; Peppas, Nicholas A.

doi:10.1146/annurev-chembioeng-073009-100847

Cited by 1,608Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryHydrogels: synthesis, properties, applications

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Polymers for Drug Delivery Systems

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Liechty, William B., Kryscio, David R., Slaughter, Brandon V., Peppas, Nicholas A.·2010·Annual Review of Chemical and Biomolecular Engineering

DOI 10.1146/annurev-chembioeng-073009-100847PMC PMC3438887

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Abstract

Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs. From early beginnings using off-the-shelf materials, the field has grown tremendously, driven in part by the innovations of chemical engineers. Modern advances in drug delivery are now predicated upon the rational design of polymers tailored for specific cargo and engineered to exert distinct biological functions. In this review, we highlight the fundamental drug delivery systems and their mathematical foundations and discuss the physiological barriers to drug delivery. We review the origins and applications of stimuli-responsive polymer systems and polymer therapeutics such as polymer-protein and polymer-drug conjugates. The latest developments in polymers capable of molecular recognition or directing intracellular delivery are surveyed to illustrate areas of research advancing the frontiers of drug delivery.

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Polymeric nanomaterials entrap drug efficiently and allow sustained release or stimuli-responsive release.
“Polymeric nanomaterials entrap the drug efficiently and either allow drug release in a sustained manner or facilitate the release kinetics in response to cellular or extracellular stimuli, such as temperature, pH, and redox potential.164”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [164]

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Authors: Liechty, W. B., Kryscio, D. R., Slaughter, B. V., & Peppas, N. A.
Affiliations: The University of Texas at Austin (US)
ORCID: Peppas, Nicholas A.
Venue: Annual Review of Chemical and Biomolecular Engineering
Publisher: Annual Reviews
Published: 2010-06-15
Volume: 1
Issue: 1
Pages: 149-173
ISSN: 1947-5438 (ISSN-L)
1947-5446
DOI: 10.1146/annurev-chembioeng-073009-100847
PMC: PMC3438887
OpenAlex: W2107660675
Cited by: 1,608
References: 157
Citations by year: 2026: 73 · 2025: 97 · 2024: 143 · 2023: 140 · 2022: 178 · 2021: 165 · 2020: 154 · 2019: 147 · 2018: 106 · 2017: 110 · 2016: 78 · 2015: 65 · 2014: 53 · 2013: 42 · 2012: 26
FWCI: 4.24
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Annual Review of Chemical and Biomolecular Engineering (publishedVersion, public-domain)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5r01eb000246-20)
National Cancer Institute (U54CA143837)
National Institute of Biomedical Imaging and Bioengineering (R01-EB000246, EB000426)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Keywords: drug delivery systems, controlled drug release, stimuli-responsive polymers, polymer-drug conjugates, protein-polymer conjugates, polymer therapeutics, molecular recognition, intracellular delivery, mathematical modeling of drug release, hydrophilic and hydrophobic drugs
MeSH terms: Animals, Delayed-Action Preparations, Pharmaceutical Preparations, Humans, Polymers, Proteins

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