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Cited by 180

The DOI matches its Crossref record.

Triply Triggered Doxorubicin Release From Supramolecular Nanocontainers

Loh, Xian Jun, del Barrio, Jesús, Toh, Pearl Pei Chern, Lee, Tung-Chun, Jiao, Dezhi, Rauwald, Urs, Appel, Eric A., Scherman, Oren A.·2012·Biomacromolecules
DOI 10.1021/bm201588m
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Abstract

The synthesis of a supramolecular double hydrophilic block copolymer (DHBC) held together by cucurbit[8]uril (CB[8]) ternary complexation and its subsequent self-assembly into micelles is described. This system is responsive to multiple external triggers including temperature, pH and the addition of a competitive guest. The supramolecular block copolymer assembly consists of poly(N-isopropylacrylamide) (PNIPAAm) as a thermoresponsive block and poly(dimethylaminoethylmethacrylate) (PDMAEMA) as a pH-responsive block. Moreover, encapsulation and controlled drug release was demonstrated with this system using the chemotherapeutic drug doxorubicin (DOX). This triple stimuli-responsive DHBC micelle system represents an evolution over conventional double stimuli-responsive covalent diblock copolymer systems and displayed a significant reduction in the viability of HeLa cells upon triggered release of DOX from the supramolecular micellar nanocontainers.

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Metadata

Authors
Loh, X. J., del Barrio, J., Toh, P. P. C., Lee, T.-C., Jiao, D., Rauwald, U., Appel, E. A., & Scherman, O. A.
Venue
Biomacromolecules
Publisher
American Chemical Society (ACS)
Published
2011-12-23
Volume
13
Issue
1
Pages
84-91
ISSN
  • 1525-7797 (ISSN-L)
  • 1526-4602
DOI
10.1021/bm201588m
OpenAlex
W2029063312
Cited by
180
References
0
FWCI
7.65
Type
journal article
Language
en
Open access
closed

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