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Interaction of β-Lactoglobulin with Resveratrol and its Biological Implications
Abstract
Beta-lactoglobulin (beta-LG), the major whey protein in the milk of ruminants, has a high affinity for a wide range of compounds. Resveratrol (3,5,4'-trihydroxystilbene), a natural polyphenolic compound found in grapes and red wine, exhibits many physiological effects associated with health benefits. In this study, the interaction of resveratrol with beta-LG was investigated using circular dichroism, fluorescence and UV-vis absorbance. Self-association of resveratrol possibly occurs at high concentrations. Resveratrol interacts with beta-LG to form 1:1 complexes. Resveratrol is bound to the surface of the protein because beta-LG-bound polyphenol is in a weaker hydrophobic environment relative to 75% ethanol. The binding constant for the resveratrol-beta-LG interaction is between 10(4) and 10(6) M (-1), as determined by protein or polyphenol fluorescence. The beta-LG-resveratrol interaction may compete with self-association of both the polyphenol and the protein. It has no apparent influence on beta-LG secondary structure but partially disrupts tertiary structure. Complexing with beta-LG provides a slight increase in the photostability of resveratrol and a significant increase in its hydrosolubility.
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Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935
Cited by
Wang, K.-Q., Luo, S.-Z., Zhong, X.-Y., Cai, J., Jiang, S.-T., & Zheng, Z. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2016.07.037 · Cited by 423
Metadata
- Authors
- Liang, L., Tajmir-Riahi, H. A., & Subirade, M.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-12-08
- Volume
- 9
- Issue
- 1
- Pages
- 50-56
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W1995931234
- Cited by
- 472
- References
- 1
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liang, L., Tajmir-Riahi, H. A., & Subirade, M. (2008). Interaction of β-Lactoglobulin with Resveratrol and its Biological Implications. Biomacromolecules. https://doi.org/10.1021/bm700728k
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