Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Abstract
Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Resveratrol has anticancer properties.
“The scientific interest in resveratrol dates back to 1997 when studies on animal models demonstrated its anticancer properties [7].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [7]
Cites
Aspirin Use and Reduced Risk of Fatal Colon Cancer
Thun, M. J., Namboodiri, M. M., & Heath, C. W. (1991) · New England Journal of Medicine · doi:10.1056/nejm199112053252301 · Cited by 1,682 · see citing works
Prospective study of alcohol consumption and risk of coronary disease in men.
Rimm, E. B., Giovannucci, E. L., Willett, W. C., Colditz, G. A., Ascherio, A., Rosner, B., & Stampfer, M. J. (1991) · The Lancet · doi:10.1016/0140-6736(91)90542-w · Cited by 1,239 · see citing works
Pace-Asciak, C. R., Hahn, S., Diamandis, E. P., Soleas, G. J., & Goldberg, D. M. (1995) · Clinica Chimica Acta · doi:10.1016/0009-8981(95)06045-1 · Cited by 871 · see citing works
Zhang, Y., Kensler, T. W., Cho, C., Posner, G. H., & Talalay, P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3147 · Cited by 746 · see citing works
Klatsky, A. L., Armstrong, M. A., & FRIEDMAN, G. D. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-8-646 · Cited by 538 · see citing works
Prochaska, H. J., & Santamaria, A. B. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90292-8 · Cited by 495 · see citing works
Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase
Gierse, J. K., Hauser, S. D., Creely, D., Koboldt, C. M., Rangwala, S. H., Isakson, P. C., & Seibert, K. (1995) · Biochemical Journal · doi:10.1042/bj3050479 · Cited by 412 · see citing works
Sulindac for polyposis of the colon
Waddell, W. R., Ganser, G. F., Cerise, E. J., & Loughry, R. W. (1989) · The American Journal of Surgery · doi:10.1016/0002-9610(89)90442-x · Cited by 409 · see citing works
Jeandet, P., Bessis, R., & Gautheron, B. (1991) · American Journal of Enology and Viticulture · doi:10.5344/ajev.1991.42.1.41 · Cited by 401 · see citing works
Chemoprevention of cancer with retinoids
Peck, G. L. (1981) · Gynecologic Oncology · doi:10.1016/0090-8258(81)90086-x · Cited by 366 · see citing works
Subversion of immune system by tumor cells and role of prostaglandins.
Plescia, O. J., Smith, A. H., & Grinwich, K. D. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.5.1848 · Cited by 354 · see citing works
Beyond alcohol: Beverage consumption and cardiovascular mortality
Goldberg, D. M., Hahn, S. E., & Parkes, J. G. (1995) · Clinica Chimica Acta · doi:10.1016/0009-8981(95)06069-p · Cited by 290 · see citing works
Effects of stilbenes on arachidonate metabolism in leukocytes
Kimura, Y., Hiromichi, O., & Arichi, S. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90167-5 · Cited by 273 · see citing works
Screening of potential chemopreventive agents using biochemical markers of carcinogenesis.
Sharma, S., Stutzman, J. D., Kelloff, G. J., & Steele, V. E. (1994) · PubMed · Cited by 264 · see citing works
ARICHI, H., KIMURA, Y., OKUDA, H., BABA, K., KOZAWA, M., & ARICHI, S. (1982) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.30.1766 · Cited by 255 · see citing works
Kinase Inhibitors from Polygonum cuspidatum
Jayatilake, G. S., Jayasuriya, H., Lee, E.-S., Koonchanok, N. M., Geahlen, R. L., Ashendel, C. L., McLaughlin, J. L., & Chang, C. (1993) · Journal of Natural Products · doi:10.1021/np50100a021 · Cited by 233 · see citing works
Hughes, T. A., Gwynne, J. T., Switzer, B. R., Herbst, C. A., & White, G. (1984) · The American Journal of Medicine · doi:10.1016/0002-9343(84)90429-7 · Cited by 185 · see citing works
Prostaglandins and related substances: A practical approach
Hoult, R. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80151-0 · Cited by 150 · see citing works
Epidemiology of Coronary Heart Disease—Influence of Alcohol
Klatsky, A. L. (1994) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1994.tb00886.x · Cited by 146 · see citing works
Gerhäuser, C., Mar, W., Lee, S. K., Suh, N., Luo, Y., Kosmeder, J. W., Luyengi, L., Fong, H. H. S., Kinghorn, A. D., Moriarty, R. M., et al. (1995) · Nature Medicine · doi:10.1038/nm0395-260 · Cited by 143 · see citing works
Self-citationRomero‐Pérez, A. I., Lamuela-Raventós, R. M., Waterhouse, A. L., & de la Torre-Boronat, M. C. (1996) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9507654 · Cited by 142 · see citing works
Prostaglandins and related substances : a practical approach
Benedetto, C. (1987) · IRL Press eBooks · Cited by 114 · see citing works
The suppressive effect of piroxicam on autochthonous intestinal tumors in the rat
Pollard, M., Luckert, P. H., & Schmidt, M. A. (1983) · Cancer Letters · doi:10.1016/0304-3835(83)90082-4 · Cited by 106 · see citing works
Discovery of natural product chemopreventive agents utilizing HL-60 cell differentiation as a model.
Suh, N., Luyengi, L., Fong, H. H. S., Kinghorn, A. D., & Pezzuto, J. M. (1995) · PubMed · Cited by 104 · see citing works
Self-citationAntitumor activity of indomethacin on methylazoxymethanol-induced large bowel tumors in rats.
Kudo, T., Narisawa, T., & Abo, S. (1980) · PubMed · Cited by 96 · see citing works
Prevention--therapy--basic science and the resolution of the cancer problem.
Wattenberg, L. W. (1993) · PubMed · Cited by 90 · see citing works
WILD, D., & Degen, G. H. (1987) · Carcinogenesis · doi:10.1093/carcin/8.4.541 · Cited by 73 · see citing works
Immunologic Effects of Nonsteroidal Anti-Inflammatory Drugs
Goodwin, J. S. (1984) · The American Journal of Medicine · doi:10.1016/s0002-9343(84)80086-8 · Cited by 67 · see citing works
Anti-inflammatory activity of leaf extracts of Eugenia jambos in rats
Slowing, K., Carretero, E., & Villar, A. (1994) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(94)90110-4 · Cited by 60 · see citing works
Self-citation[9] Purification of PGH synthase from sheep vesicular glands
van der Ouderaa, F. J. G., & Buytenhek, M. (1982) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(82)86169-7 · Cited by 41 · see citing works
Zenser, T. V., Mattammal, M. B., Wise, R., Rice, J. R., & Davis, B. B. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22003-1 · Cited by 38 · see citing works
La, S., Chen, C., Rg, M., Steele, V., Rc, M., & Jm, P. (1994) · PubMed · Cited by 13 · see citing works
Flagged first, then by citations
1 of the 33 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Therapeutic potential of resveratrol: the in vivo evidence
Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958 · see citing works
“2 ) have shown that resveratrol can prevent or slow the progression of a wide variety of illnesses, including cance”
BackgroundSmall molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796 · see citing works
“The most potent activator was resveratrol (3,5,4′-trihydroxystilbene), a polyphenol found in red wine that is associated with a surprising number of health benefits, most notably the mitigation of age-related diseases, including neurodegeneration, carcinogenesis and atherosclerosi”
BackgroundDietary Intake and Bioavailability of Polyphenols
Scalbert, A., & Williamson, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2073s · Cited by 3,658 · see citing works
Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358696 · Cited by 3,262 · see citing works
Dietary polyphenols and the prevention of diseases
Scalbert, A., Manach, C., Morand, C., Rémésy, C., & Jiménez, L. (2005) · Critical Reviews in Food Science and Nutrition · doi:10.1080/1040869059096 · Cited by 2,999 · see citing works
“[145] Jang, M.”
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750 · see citing works
“In addition to promoting apoptosis and displaying antitumor activities in vivo, resveratrol is also a known inhibitor of NF-kB transcription (Jang et al, 1997; Holmes-McNary and Baldwin, 2000; Manna et al, 2000).”
BackgroundPlant Polyphenols: Chemical Properties, Biological Activities, and Synthesis
Quideau, S., Deffieux, D., Douat, C., & Pouységu, L. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201000044 · Cited by 2,753 · see citing works
Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer
Kris‐Etherton, P. M., Hecker, K. D., Bonanome, A., Coval, S. M., Binkoski, A. E., Hilpert, K. F., Griel, A. E., & Etherton, T. D. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00995-0 · Cited by 2,544 · see citing works
Mammalian Sirtuins: Biological Insights and Disease Relevance
Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085 · see citing works
Dietary phenolics: chemistry, bioavailability and effects on health
Crozier, A., Jaganath, I. B., & Clifford, M. N. (2009) · Natural Product Reports · doi:10.1039/b802662a · Cited by 2,002 · see citing works
HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS
Walle, T., Hsieh, F., DeLegge, M. H., Oatis, J. E., & Walle, U. K. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.000885 · Cited by 1,893 · see citing works
“Resveratrol is a dietary antioxidant polyphenol, found in grapes, red wine, and peanuts, that has been strongly indicated to have protective effects against cardiovascular disease and, in particular, cancer, including all stages of carcinogenesis (Jang et al., 1997; Bhat and Pezzuto, 2002; Pervaiz, 2003).”
BackgroundDrug discovery from medicinal plants
Balunas, M. J., & Kinghorn, A. D. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.09.012 · Cited by 1,803 · see citing works
“(Fabaceae), a botanical dietary supplement commonly known as tonka bean, collected in Peru (Jang et al., 2003).”
BackgroundSelf-citationBiological effects of resveratrol
Frémont, L. (2000) · Life Sciences · doi:10.1016/s0024-3205(99)00410-5 · Cited by 1,663 · see citing works
Polyketide biosynthesis: a millennium review
Staunton, J., & Weissman, K. J. (2001) · Natural Product Reports · doi:10.1039/a909079g · Cited by 1,642 · see citing works
Surh, Y., Chun, K., Cha, H.-H., Han, S. S., Keum, Y., Park, K.-K., & Lee, S. S. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00183-x · Cited by 1,620 · see citing works
Wright, J. S., Johnson, E. R., & DiLabio, G. A. (2001) · Journal of the American Chemical Society · doi:10.1021/ja002455u · Cited by 1,616 · see citing works
Price, N. L., Gomes, A. P., Ling, A. J. Y., Duarte, F. V., Martin-Montalvo, A., North, B. J., Agarwal, B., Ye, L., Ramadori, G., Teodoro, J. S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.003 · Cited by 1,602 · see citing works
“The polyphenol resveratrol (2,3,4′-trihydroxystilbene) first attracted scientific attention when it was linked to the cardiovascular benefits of red wine and was subsequently found to possess potent anti-tumor activity (Jang et al., 1997).”
BackgroundApplications and opportunities for ultrasound assisted extraction in the food industry — A review
Vilkhu, K., Mawson, R., Simons, L., & Bates, D. (2008) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2007.04.014 · Cited by 1,394 · see citing works
Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.
Aggarwal, B. B., Bhardwaj, A., Aggarwal, R. S., Seeram, N. P., Shishodia, S., & Takada, Y. (2004) · PubMed · Cited by 1,383 · see citing works
Bitter taste, phytonutrients, and the consumer: a review
Drewnowski, A., & Gomez-Carneros, C. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.6.1424 · Cited by 1,366 · see citing works
Phenolic compounds and related enzymes as determinants of quality in fruits and vegetables
Tomás-Barberán, F. A., & Espı́n, J. C. (2001) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.885 · Cited by 1,289 · see citing works
The molecular basis of working mechanism of natural polyphenolic antioxidants
Leopoldini, M., Russo, N., & Toscano, M. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.08.012 · Cited by 1,277 · see citing works
“It is one of the main non alcoholic components in the red wines (Jang et al., 1997).”
BackgroundYang, C. S., Landau, J. M., Huang, M.-T., & Newmark, H. L. (2001) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.21.1.381 · Cited by 1,260 · see citing works
Masella, R., Benedetto, R. D., Varı́, R., Filesi, C., & Giovannini, C. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.05.013 · Cited by 1,109 · see citing works
“Resveratrol, considered as an active cardioprotective component of red wine, enhanced the activity of phase II enzymes [159,160].”
BackgroundNichols, J. A., & Katiyar, S. K. (2010) · Archives of Dermatological Research · doi:10.1007/s00403-009-1001-3 · Cited by 1,103 · see citing works
“Topical application of resveratrol inhibits UVB-induced skin tumor initiation, promotion and progression [4, 29].”
BackgroundGehm, B. D., McAndrews, J. M., Chien, P.-Y., & Jameson, J. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.14138 · Cited by 1,053 · see citing works
Epigenetic mechanisms of longevity and aging
Sen, P., Shah, P. P., Nativio, R., & Berger, S. L. (2016) · Cell · doi:10.1016/j.cell.2016.07.050 · Cited by 956 · see citing works
Plant Foods and Herbal Sources of Resveratrol
Burns, J., Yokota, T., Ashihara, H., Lean, M. E. J., & Crozier, A. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0112973 · Cited by 1,000 · see citing works
The therapeutic potential of resveratrol: a review of clinical trials
Berman, A. Y., Motechin, R. A., Wiesenfeld, M. Y., & Holz, M. K. (2017) · npj Precision Oncology · doi:10.1038/s41698-017-0038-6 · Cited by 895 · see citing works
Manna, S. K., Mukhopadhyay, A., & Aggarwal, B. B. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6509 · Cited by 876 · see citing works
“Similarly, 98% inhibition of DMBA plus phorbol ester-induced skin tumors in mice occurred by a topical application of 25mM resveratrol (14).”
InfluentialAlao, J. P. (2007) · Molecular Cancer · doi:10.1186/1476-4598-6-24 · Cited by 862 · see citing works
Chemical and Instrumental Approaches to Treat Hyperpigmentation
Briganti, S., Camera, E., & Picardo, M. (2003) · Pigment Cell Research · doi:10.1034/j.1600-0749.2003.00029.x · Cited by 834 · see citing works
Boocock, D. J., Faust, G. E. S., Patel, K. R., Schinas, A. M., Brown, V. A., Ducharme, M. P., Booth, T. D., Crowell, J. A., Perloff, M., Gescher, A. J., et al. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0022 · Cited by 823 · see citing works
“Resveratrol interferes with all three stages of carcinogenesis initiation, promotion, and progression (5).”
BackgroundInfluentialNutraceuticals: Facts and fiction
Espı́n, J. C., García‐Conesa, M., & Tomás-Barberán, F. A. (2007) · Phytochemistry · doi:10.1016/j.phytochem.2007.09.014 · Cited by 814 · see citing works
Li, X., Fang, P., Mai, J., Choi, E. T., Wang, H., & Yang, X. (2013) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-6-19 · Cited by 810 · see citing works
“Resveratrol has shown promising clinical benefits as anti-aging [60], antiinflammatory [61], anti-diabetic [62], anti-viral [63], anti-neoplastic [64], and anti-CVD agents [65].”
BackgroundCragg, G. M. L., & Pezzuto, J. M. (2015) · Medical Principles and Practice · doi:10.1159/000443404 · Cited by 807 · see citing works
Self-citationThe Role of Resveratrol in Cancer Therapy
Ko, J., Sethi, G., Um, J., Shanmugam, M. K., Arfuso, F., Kumar, A. P., Bishayee, A., & Ahn, K. S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122589 · Cited by 806 · see citing works
“Skin DMBA/TPA model in female CD-1 mice 1, 5, 10, 25 μmol topically twice/week for 18 weeks Incidence↓ Number of tumors per mouse↓ [46]”
BackgroundMethodInfluentialShimada, T., & Fujii‐Kuriyama, Y. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb03162.x · Cited by 805 · see citing works
Valenzano, D. R., Tozzini, E. T., Genade, T., Cattaneo, A., Domenici, L., & Cellerino, A. (2006) · Current Biology · doi:10.1016/j.cub.2005.12.038 · Cited by 786 · see citing works
“It was reported to have anticancer and antiinflammatory action in vitro [26, 27] and neuroprotective action in vitro [6, 7, 9, 10, 28] and in vivo [10].”
BackgroundSubbaramaiah, K., Chung, W. J., Michaluart, P., TELANG, N. T., Tanabe, T., Inoue, H., Jang, M., Pezzuto, J. M., & Dannenberg, A. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.34.21875 · Cited by 786 · see citing works
Self-citationSurh, Y., Kundu, J. K., & Na, H. (2008) · Planta Medica · doi:10.1055/s-0028-1088302 · Cited by 759 · see citing works
Cocoa Has More Phenolic Phytochemicals and a Higher Antioxidant Capacity than Teas and Red Wine
Lee, K. W., Kim, Y. J., Lee, H. J., & Lee, C. Y. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0344385 · Cited by 748 · see citing works
Gambini, J., Inglés, M., González, G. O., López-Grueso, R., Bonet-Costa, V., Gimeno-Mallench, L., Mas‐Bargues, C., Abdelaziz, K. M., Gómez‐Cabrera, M. C., Viña, J., et al. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/837042 · Cited by 752 · see citing works
“For example, its preventive effect on the initiation of cancer has been determined in a skin cancer animal model, with a concentration between 1 and 25 μM of resveratrol, and administrated twice a week [90].”
BackgroundInfluentialResveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications
Alarcón‐de‐la‐Lastra, C., & Villegas, I. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351156 · Cited by 740 · see citing works
Resveratrol: A review of preclinical studies for human cancer prevention
Athar, M., Back, J. H., Tang, X., KIM, K., Kopelovich, L., Bickers, D. R., & Kim, A. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.12.025 · Cited by 733 · see citing works
“Similarly in a standard chemical carcinogenesis mouse tumor protocol using a twostage, DMBA-initiated and TPA-promoted murine skin cancer model showed a 98% reduction in skin tumors (Jang et al., 1997).”
MethodAnti-Inflammatory Action and Mechanisms of Resveratrol
Meng, T., Xiao, D., Muhammed, A., Deng, J., Chen, L., & He, J. (2021) · Molecules · doi:10.3390/molecules26010229 · Cited by 730 · see citing works
“[28] found that this polyphenol was able to selectively suppress the COX activity of COX-1 and this isoenzyme’s hydroperoxidase activity, thus inhibiting PG synthesis.”
BackgroundAntioxidant Properties of Phenolic Compounds: H-Atom versus Electron Transfer Mechanism
Leopoldini, M., Marino, T., Russo, N., & Toscano, M. (2004) · The Journal of Physical Chemistry A · doi:10.1021/jp037247d · Cited by 707 · see citing works
Resveratrol as an anti-inflammatory and anti-aging agent: Mechanisms and clinical implications
Alarcón‐de‐la‐Lastra, C., & Villegas, I. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500022 · Cited by 705 · see citing works
“3) known to be able to convert substances into mutagens, as mentioned above; and (ii) acting as an antioxidant through inhibition of DNA damage by free radicals [14].”
BackgroundInfluentialBrown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2364 · Cited by 691 · see citing works
“has been demonstrated to prevent cancer, or delay its onset, in a variety of rodent models of carcinogenesis (1,2).”
Ramassamy, C. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.06.025 · Cited by 680 · see citing works
Metabolism and bioavailability oftrans-resveratrol
Wenzel, E., & Somoza, V. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500010 · Cited by 677 · see citing works
Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis.
Noel, J. P., Ferrer, J.-L., Jez, J. M., Bowman, M. E., & Dixon, R. A. (1999) · Nature Structural Biology · doi:10.1038/11553 · Cited by 673 · see citing works
“As medicinal natural products, the phenylpropanoids exhibit cancer chemopreventiv”
BackgroundResveratrol as an anti-cancer agent: A review
Rauf, A., Imran, M., Butt, M. S., Nadeem, M., Peters, D. G., & Mubarak, M. S. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1263597 · Cited by 672 · see citing works
“This compound has become very popular due to its anti-cancer potential, first reported in 1997 (Jang et al., 1997).”
BackgroundChalcone synthase and its functions in plant resistance
Dao, T. T. H., Linthorst, H. J. M., & Verpoorte, R. (2011) · Phytochemistry Reviews · doi:10.1007/s11101-011-9211-7 · Cited by 660 · see citing works
“Flavonoids also have benefits for human health, as they exhibit amongst others cancer chemopreventive (Jang et al. 1997), antimitotic (Edwards et al. 1990), estrogenic (Gehm et al. 1997) antimalarial (Li et al. 1995) antioxidant (Jang et al. 1997) and antiasthmatic (Zwaagstra et al. 1997)…”
BackgroundBiochemical changes throughout grape berry development and fruit and wine quality
Conde, C., Silva, P., Fontes, N., Dias, A. C. P., Tavares, R. M., Sousa, M. J., Agasse, A., Delrot, S., & Gerós, H. (2007) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 653 · see citing works
Surh, Y.-J. (1999) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s1383-5742(99)00057-5 · Cited by 633 · see citing works
Tobacco, alcohol, and socioeconomic status and adenocarcinomas of the esophagus and gastric cardia
Gammon, M. D., Schoenberg, J. B., Ahsan, H., Risch, H. A., Vaughan, T. L., Chow, W., Rotterdam, H., West, A. B., Dubrow, R., Stanford, J. L., et al. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.17.1277 · Cited by 622 · see citing works
“If the reduction in risk is real, there may be a protective ingredient in wine, such as resveratrol ( 28 ), that is not present in beer or liquor.”
BackgroundAdministration of resveratrol: What formulation solutions to bioavailability limitations?
Amri, A., Chaumeil, J. C., Sfar, S., & Charrueau, C. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.09.083 · Cited by 622 · see citing works
Polyphenolics in Grape Seeds—Biochemistry and Functionality
Shi, J., Yu, J., Pohorly, J. E., & Kakuda, Y. (2003) · Journal of Medicinal Food · doi:10.1089/109662003772519831 · Cited by 817 · see citing works
“Another anticarcinogenic study conducted by Jang et al .”
Solid‐phase microextraction: a powerful sample preparation tool prior to mass spectrometric analysis
Vas, G., & Vékey, K. (2004) · Journal of Mass Spectrometry · doi:10.1002/jms.606 · Cited by 615 · see citing works
Kapetanović, I. M., Muzzio, M., Huang, Z., Thompson, T. N., & McCormick, D. L. (2010) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-010-1525-4 · Cited by 613 · see citing works
“[17] reported that resveratrol has a number of biological activities that are consistent with cancer chemoprevention and that the agent can inhibit carcinogenesis in experimental animals.”
BackgroundClement, M., Hirpara, J. L., Chawdhury, S.-H., & Pervaiz, S. (1998) · Blood · doi:10.1182/blood.v92.3.996 · Cited by 611 · see citing works
Shimada, T. (2006) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.21.257 · Cited by 606 · see citing works
Resveratrol and health—A comprehensive review of human clinical trials
Smoliga, J. M., Baur, J. A., & Hausenblas, H. A. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100143 · Cited by 594 · see citing works
“Resveratrol further inhibits cyclooxygenases [19], and could therefore act through some of the same mechanisms as aspirin.”
BackgroundCancer Chemoprevention Through Dietary Antioxidants: Progress and Promise
Khan, N., Afaq, F., & Mukhtar, H. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1740 · Cited by 592 · see citing works
“According to their study, resveratrol significantly reduced the number of tumors per mouse in a two-stage skin carcinogenesis model (120).”
Polyphenols: do they play a role in the prevention of human pathologies?
Tapiero, H., Tew, K. D., Ba, G. N., & Mathé, G. (2002) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(02)00178-6 · Cited by 589 · see citing works
Resveratrol, Pterostilbene, and Piceatannol in Vaccinium Berries
Rimando, A. M., Kalt, W., Magee, J. B., Dewey, J., & Ballington, J. R. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf040095e · Cited by 583 · see citing works
Hoffmann, L., Besseau, S., Geoffroy, P., Ritzenthaler, C., Meyer, D., Lapierre, C., Pollet, B., & Legrand, M. (2004) · The Plant Cell · doi:10.1105/tpc.020297 · Cited by 582 · see citing works
“Among the myriad of plant natural products, compounds issuing from the phenylpropanoid pathway (Figure 1) have been reported to have antioxidant effects, estrogen-like and vasodilatation activities, and anti-inflammatory and anticancer chemopreventive action (Jang et al., 1997; Kahkonen et al., 1999; Burns et al., 200…”
BackgroundInfluentialPerspectives for Cancer Prevention With Natural Compounds
Amin, A. R. M. R., Küçük, Ö., Khuri, F. R., & Shin, D. M. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.20.6235 · Cited by 568 · see citing works
Sirtuins: Sir2-related NAD-dependent protein deacetylases.
North, B. J., & Verdin, E. M. (2004) · Genome biology · doi:10.1186/gb-2004-5-5-224 · Cited by 568 · see citing works
Plant-derived anticancer agents
Pezzuto, J. M. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(96)00654-5 · Cited by 564 · see citing works
Self-citationToward a unified theory of caloric restriction and longevity regulation
Sinclair, D. A. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.019 · Cited by 561 · see citing works
“Examples include the inhibition of cyclooxygenases (Jang et al., 1997), PI 3 kinase (PozoGuisado et al.”
BackgroundInfluentialOxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment
Chikara, S., Nagaprashantha, L. D., Singhal, J., Horne, D. A., Awasthi, S., & Singhal, S. S. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.11.002 · Cited by 561 · see citing works
Cancer revoked: oncogenes as therapeutic targets
Felsher, D. (2003) · Nature Reviews. Cancer · doi:10.1038/nrc1070 · Cited by 501 · see citing works
Wang, S. F., Su, R., Nie, S., Sun, M., Zhang, J., Wu, D., & Moustaïd‐Moussa, N. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.10.002 · Cited by 532 · see citing works
“Resveratrol has antioxidant, anti-inflammatory and anticarcinogenic properties [34,128,129].”
Cancer Prevention and Treatment with Resveratrol: From Rodent Studies to Clinical Trials
Bishayee, A. (2009) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0160 · Cited by 530 · see citing works
“(12), the first animal study of the chemopreventive effects of resveratrol was reported in a two-stage mouse skin carcinogenesis model.”
BackgroundIMPROVING THE NUTRIENT COMPOSITION OF PLANTS TO ENHANCE HUMAN NUTRITION AND HEALTH
Grusak, M. A., & DellaPenna, D. (1999) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.50.1.133 · Cited by 530 · see citing works
“These include flavonoids, flavones, phytosterols, phenols and polyphenols, phytoestrogens, glucosinolates, and indoles, to name but a few (11, 27, 33, 37, 69, 82, 152).”
BackgroundWang, H., Khor, T., Shu, L.-M., Su, Z.-C., Fuentes, F., Lee, J.-H., & Kong, A. (2012) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152012803833026 · Cited by 532 · see citing works
“Jang et al reported cancer chemopreventive activity of resveratrol [164].”
Resveratrol Acts as a Mixed Agonist/Antagonist for Estrogen Receptors α and β*
Bowers, J. L., Tyulmenkov, V. V., Jernigan, S. C., & Klinge, C. M. (2000) · Endocrinology · doi:10.1210/endo.141.10.7721 · Cited by 527 · see citing works
New concepts in nutraceuticals as alternative for pharmaceuticals.
Nasri, H., Baradaran, A., Shirzad, H., & Rafieian‐Kopaei, M. (2014) · Europe PMC (PubMed Central) · Cited by 525 · see citing works
Type of Alcohol Consumed and Mortality from All Causes, Coronary Heart Disease, and Cancer
Grønbæk, M., Becker, U., Johansen, D., Gottschau, A., Schnohr, P., Hein, H. O., Jensen, G., & Sørensen, T. I. A. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-6-200009190-00008 · Cited by 525 · see citing works
“It is further supported by the results of our recent study of the relation between beer, wine, and spirits and cancer of the upper digestive tract (41), although these cancers are rare.”
ResultResveratrol and cancer: focus on in vivo evidence
Carter, L. G., D'Orazio, J. A., & Pearson, K. J. (2014) · Endocrine Related Cancer · doi:10.1530/erc-13-0171 · Cited by 523 · see citing works
“After Jang et al .”
Health benefits of resveratrol: Evidence from clinical studies
Singh, A. P., Singh, R., Verma, S. S., Rai, V., Kaschula, C. H., Maiti, P., & Gupta, S. C. (2019) · Medicinal Research Reviews · doi:10.1002/med.21565 · Cited by 523 · see citing works
“Since its identification in 1939, resveratrol’s pleiotropic activities have been reported in a number of studies.(3,257) However, most of these discussions are based on preclinical work.”
BackgroundResveratrol: from grapevines to mammalian biology
Pervaiz, S. (2003) · The FASEB Journal · doi:10.1096/fj.03-0168rev · Cited by 518 · see citing works
“Results indicated that the presence of RSV prevented the activation of NF- B triggered by exposure of these cell types to TNF, PMA, H2O2, LPS, okadaic acid, and ceramide (15).”
BackgroundInfluentialTsai, S., Lin‐Shiau, S., & Lin, J. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702357 · Cited by 512 · see citing works
Biological Effects of Resveratrol
Bhat, K., Kosmeder, J. W., & Pezzuto, J. M. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601317203567 · Cited by 510 · see citing works
“Resveratrol has been shown to in-BHAT hibit the activity of the COX-1 enzyme derived from sheep seminal vesicles (68, 112).”
InfluentialSelf-citationXia, C., Meng, Q., Liu, L.-Z., Rojanasakul, Y., Wang, X., & Jiang, B. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0783 · Cited by 508 · see citing works
Resveratrol for cancer therapy: Challenges and future perspectives
Ren, B., Kwah, M. X.-Y., Liu, C., Ma, Z., Shanmugam, M. K., Ding, L., Xiang, X., Ho, P. C., Wang, L., Ong, P. S., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.05.001 · Cited by 505 · see citing works
Resveratrol: a review of plant sources, synthesis, stability, modification and food application
Tian, B., & Liu, J. (2019) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10152 · Cited by 500 · see citing works
Waterhouse, A. L. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02903.x · Cited by 494 · see citing works
Resveratrol as an anticancer nutrient: molecular basis, open questions and promises
Signorelli, P., & Ghidoni, R. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.01.017 · Cited by 493 · see citing works
“Resveratrol noncompetitively inhibited both the COX and hydroperoxidase activities of COX1 in vitro [13,89].”
BackgroundMethodInfluentialStivala, L. A., Savio, M., Carafoli, F., Perucca, P., Bianchi, L. C., Maga, G., Forti, L., PAGNONI, U. M., Albini, A., Prosperi, E., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101846200 · Cited by 492 · see citing works
Cancer Prevention With Natural Compounds
Gullett, N. P., Amin, A. R. M. R., Bayraktar, S., Pezzuto, J. M., Shin, D. M., Khuri, F. R., Aggarwal, B. B., Surh, Y., & Küçük, Ö. (2010) · Seminars in Oncology · doi:10.1053/j.seminoncol.2010.06.014 · Cited by 490 · see citing works
Self-citationImproving industrial yeast strains: exploiting natural and artificial diversity
Steensels, J., Snoek, T., Meersman, E., Nicolino, M. P., Voordeckers, K., & Verstrepen, K. J. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12073 · Cited by 486 · see citing works
“Resveratrol is a compound that, apart from its antifungal characteristics, has been proposed to reduce the risk of cancer and coronary heart disease (Jang et al., 1997; Becker et al., 2003).”
BackgroundMarier, J., Vachon, P., Gritsas, A., Zhang, J., Moreau, J., & Ducharme, M. P. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.033340 · Cited by 480 · see citing works
“Finally, trans-resveratrol was shown to have cancer chemoprotective properties and to induce apoptosis in leukemia and human breast carcinoma (Jang et al., 1997; Mgbonyebi et al., 1998; Lu and Serrero, 1999).”
BackgroundTargeting NOX, iNOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals
Murakami, A., & Ohigashi, H. (2007) · International Journal of Cancer · doi:10.1002/ijc.23161 · Cited by 478 · see citing works
“Resveratrol is a well-known compound that regulates both COX-1 and COX-2.”
BackgroundThe molecular targets of resveratrol
Kulkarni, S. S., & Cantó, C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.005 · Cited by 477 · see citing works
Cyclooxygenase-2 and carcinogenesis
Prescott, S. M., & Fitzpatrick, F. A. (2000) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(00)00006-8 · Cited by 476 · see citing works
Functional foods: their role in disease prevention and health promotion
Hasler, C. M. (1998) · Food technology · Cited by 475 · see citing works
The Mediterranean diets: what is so special about the diet of Greece? The scientific evidence
Simopoulos, A. P. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.11.3065s · Cited by 473 · see citing works
- Authors
- Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., Moon, R. C., & Pezzuto, J. M.
- Affiliations
- University of Illinois Chicago (US)
- Universidad Complutense de Madrid (ES)
- M. Jang, L. Cai, C. W. W. Beecher, H. H. S. Fong, N. R. Farnsworth, A. D. Kinghorn, J. M. Pezzuto, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
- Corresponding author
- Cai, Lining
- Pezzuto, John M.
- Venue
- Science
- Published
- 1997-01-10
- Volume
- 275
- Issue
- 5297
- Pages
- 218-220
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2151089147
- Cited by
- 4,935
- References
- 33
- Citations by year
- 2026: 45 · 2025: 75 · 2024: 105 · 2023: 95 · 2022: 148 · 2021: 166 · 2020: 179 · 2019: 168 · 2018: 181 · 2017: 202 · 2016: 179 · 2015: 222 · 2014: 225 · 2013: 264 · 2012: 252
- FWCI
- 96.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- Funders
- National Cancer Institute (P01CA048112)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- resveratrol, chemoprevention, phytoalexins, grapes, antioxidant activity, antimutagenic activity, phase II enzymes, anti-inflammatory activity, cyclooxygenase inhibition, mammary carcinogenesis, precancerous lesions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
