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Peptides are Building Blocks of Heat-Induced Fibrillar Protein Aggregates of β-Lactoglobulin Formed at pH 2
Open accessAbstract
The proteinaceous material present in beta-lactoglobulin fibrils formed after heating (20 h at 85 degrees C) at pH 2 was identified during this study. Fibrils were separated from the nonaggregated material, and the fibrils were dissociated using 8 M guanidine chloride and 0.1 M 1,4-dithiothreitol (pH 8). Characterization of the different fractions was performed using thioflavin T fluorescence, high-performance size-exclusion chromatography, reversed-phase HPLC, and mass spectrometry (MALDI-TOF). Beta-lactoglobulin was found to be hydrolyzed into peptides with molecular masses between 2000 and 8000 Da, and the fibrils were composed of a part of these peptides and not intact beta-lactoglobulin. The majority of the peptides (both aggregated and nonaggregated) were a result from cleavage of the peptide bonds before or after aspartic acid residues. Explanations for the presence of certain peptide fragments in the fibrils are the hydrophobicity, low charge, charge distribution, and capacity to form beta-sheets.
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Cites
Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.
Westermark, P., Engström, U., Johnson, K. H., Westermark, G. T., & Betsholtz, C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.13.5036 · Cited by 807
Cited by
Tong, X., Cao, J., Tian, T., Lyu, B., Miao, L., Lian, Z., Cui, W., Liu, S., Wang, H., & Jiang, L. (2022) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2021.107084 · Cited by 318
Heat-Induced Denaturation, Aggregation and Gelation of Whey Proteins
Brodkorb, A., Croguennec, T., Bouhallab, S., & Kehoe, J. J. (2016) · Advanced Dairy Chemistry · doi:10.1007/978-1-4939-2800-2_6 · Cited by 124
Pepsin diffusivity in whey protein gels and its effect on gastric digestion
Luo, Q., Borst, J. W., Westphal, A. H., Boom, R. M., & Janssen, A. E. M. (2017) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2016.11.046 · Cited by 123
Self-citationDry fractionation for sustainable production of plant protein concentrates
Pelgrom, P. J. M. (2024) · doi:10.18174/331968 · Cited by 6
Metadata
- Authors
- Akkermans, C., Venema, P., van der Goot, A. J., Gruppen, H., Bakx, E. J., Boom, R. M., & van der Linden, E.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-04-17
- Volume
- 9
- Issue
- 5
- Pages
- 1474-1479
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2024534379
- Cited by
- 304
- References
- 1
- FWCI
- 19.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Akkermans, C., Venema, P., van der Goot, A. J., Gruppen, H., Bakx, E. J., Boom, R. M., & van der Linden, E. (2008). Peptides are Building Blocks of Heat-Induced Fibrillar Protein Aggregates of β-Lactoglobulin Formed at pH 2. Biomacromolecules. https://doi.org/10.1021/bm7014224
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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