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Homogeneous Quaternization of Cellulose in NaOH/Urea Aqueous Solutions as Gene Carriers
Abstract
Quaternized celluloses (QCs) were homogeneously synthesized by reacting cellulose with 3-chloro-2-hydroxypropyltrimethylammonium chloride (CHPTAC) in NaOH/urea aqueous solutions. The structure and solution properties of the QCs were characterized by using elemental analysis, FTIR, (13)C NMR, SEC-LLS, viscometer, and zeta-potential measurement. The results revealed that water-soluble QCs, with a degree of substitution (DS) value of 0.20-0.63, could be obtained by adjusting the molar ratio of CHPTAC to anhydroglucose unit (AGU) of cellulose and the reaction time. The QC solutions in water displayed a typical polyelectrolyte behavior, and the intrinsic viscosity ([eta]) value determined from the Fuoss-Strauss method increased with increasing DS value. Moreover, two QC samples (DS = 0.46 and 0.63) were selected and studied as gene carriers. The results of gel retardation assay suggested that QCs could condense DNA efficiently. QCs displayed relatively lower cytotoxicity as compared with PEI, and QC/DNA complexes exhibited effective transfection compared to the naked DNA in 293T cells. The quaternized cellulose derivatives prepared in NaOH/urea aqueous solutions could be considered as promising nonviral gene carriers.
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Citations
Cited by
Ionic Liquids and Their Interaction with Cellulose
Pinkert, A., Marsh, K. N., Pang, S., & Staiger, M. P. (2009) · Chemical Reviews · doi:10.1021/cr9001947 · Cited by 1,508
Recent advances in surface-modified cellulose nanofibrils
Rol, F., Belgacem, M. N., Gandini, A., & Bras, J. (2019) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2018.09.002 · Cited by 698
Xie, H., Du, H., Yang, X., & Si, C. (2018) · International Journal of Polymer Science · doi:10.1155/2018/7923068 · Cited by 328
Swelling Behaviors of pH- and Salt-Responsive Cellulose-Based Hydrogels
Chang, C., He, M., Zhou, J., & Zhang, L. (2011) · Macromolecules · doi:10.1021/ma102801f · Cited by 300
Self-citationCellulose Solvents – Remarkable History, Bright Future
Liebert, T. (2010) · ACS Symposium Series · doi:10.1021/bk-2010-1033.ch001 · Cited by 250
Metadata
- Authors
- Song, Y., Sun, Y., Zhang, X., Zhou, J., & Zhang, L.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-07-19
- Volume
- 9
- Issue
- 8
- Pages
- 2259-2264
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2066058992
- Cited by
- 289
- References
- 0
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Song, Y., Sun, Y., Zhang, X., Zhou, J., & Zhang, L. (2008). Homogeneous Quaternization of Cellulose in NaOH/Urea Aqueous Solutions as Gene Carriers. Biomacromolecules. https://doi.org/10.1021/bm800429a
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