The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Chitosan-Alginate Blended Nanoparticles as Carriers for the Transmucosal Delivery of Macromolecules
Open accessAbstract
Nanoparticles intended for use in the transmucosal delivery of macromolecules were prepared by the ionic gelation of chitosan (CS) hydrochloride with pentasodium tripolyphosphate (TPP) and concomitant complexation with sodium alginate (ALG). The incorporation of a small proportion of ALG of increasing molecular weight (M(w); from 4 to 74 kDa) into the nanoparticles led to a monotonic increase in colloidal size from ∼260 to ∼525 nm. This increase in size was regarded as a consequence of the formation of gradually more expanded structures. Insulin, taken as a model peptide, was associated to CS-TPP-ALG nanoparticles with efficiencies in the range of ∼41 to ∼52%, irrespective of the M(w) of the ALG incorporated in the formulation. These CS-TPP-ALG nanoparticles exhibited a capacity to enhance the systemic absorption of insulin after nasal administration to conscious rabbits. Interestingly, it was observed that the duration of the hypoglycaemic response was affected by the ALG's M(w). Briefly, this work describes a new nanoparticulate composition of potential value for increasing nasal insulin absorption.
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Cites
Colorimetric Method for Determination of Sugars and Related Substances
DuBois, M., Gilles, K. A., Hamilton, J. K., Rebers, P. A., & Smith, F. (1956) · Analytical Chemistry · doi:10.1021/ac60111a017 · Cited by 52,269
Cited by
Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery
Li, Y., Maciel, D., Rodrigues, J., Shi, X., & Tomás, H. (2015) · Chemical Reviews · doi:10.1021/cr500131f · Cited by 478
Chitosan in nasal delivery systems for therapeutic drugs
Casettari, L., & Illum, L. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.003 · Cited by 444
Review of polysaccharide particle-based functional drug delivery
Barclay, T. G., Day, C. M., Petrovsky, N., & Garg, S. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.05.067 · Cited by 396
Emerging micro- and nanotechnology based synthetic approaches for insulin delivery
Mo, R., Jiang, T., Di, J., Tai, W., & Gu, Z. (2014) · Chemical Society Reviews · doi:10.1039/c3cs60436e · Cited by 386
Chitosan-based blends for biomedical applications
Seidi, F., Khodadadi Yazdi, M., Jouyandeh, M., Dominic, M., Naeim, H., Nezhad, M. N., Bagheri, B., Habibzadeh, S., Zarrintaj, P., Saeb, M. R., et al. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.05.003 · Cited by 199
Metadata
- Authors
- Goycoolea, F. M., Lollo, G., Remuñán-López, C., Quaglia, F., & Alonso, M. J.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-06-22
- Volume
- 10
- Issue
- 7
- Pages
- 1736-1743
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2073115482
- Cited by
- 238
- References
- 1
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Goycoolea, F. M., Lollo, G., Remuñán-López, C., Quaglia, F., & Alonso, M. J. (2009). Chitosan-Alginate Blended Nanoparticles as Carriers for the Transmucosal Delivery of Macromolecules. Biomacromolecules. https://doi.org/10.1021/bm9001377
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