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Cited by 448

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Enzymatic Catalysis of Formation of Z-Aspartame in Ionic Liquid - An Alternative to Enzymatic Catalysis in Organic Solvents

Erbeldinger, M., Mesiano, A.J., Russell, A.J.·2000·Biotechnology Progress
DOI 10.1021/bp000094g
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Abstract

We present the first report of enzymatic catalysis in an ionic liquid. The virtually nonexistent vapor pressure makes ionic liquids an exciting new alternative for enzyme-catalyzed syntheses in environmentally friendly environments. Z-aspartame was synthesized in a thermolysin-catalyzed reaction of carbobenzoxy-L-aspartate and L-phenylalanine methyl ester hydrochloride in 1-butyl-3-methylimidazolium hexafluorophosphate (BP6). Ionic liquids such as BP6 are thermally stable and have a remarkable range of temperatures over which they remain liquid (300 degrees C). With an initial rate of 1.2 +/- 0.1 nmol min(-)(1) mg(-)(1), we observed a competitive rate in comparison to that of enzymatic synthesis in organic solvent. Additionally, the enzyme exhibits outstanding stability, which would normally require immobilization.

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Metadata

Authors
Erbeldinger, M., Mesiano, A. J., & Russell, A. J.
Venue
Biotechnology Progress
Publisher
Wiley
Published
2000-12-01
Volume
16
Issue
6
Pages
1129-1131
ISSN
  • 1520-6033 (ISSN-L)
  • 8756-7938
DOI
10.1021/bp000094g
OpenAlex
W2080677711
Cited by
448
References
3
FWCI
6.65
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.