The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Controllable Hydrogen Sulfide Donors and Their Activity against Myocardial Ischemia-Reperfusion Injury
Open accessAbstract
Hydrogen sulfide (H2S), known as an important cellular signaling molecule, plays critical roles in many physiological and/or pathological processes. Modulation of H2S levels could have tremendous therapeutic value. However, the study on H2S has been hindered due to the lack of controllable H2S releasing agents that could mimic the slow and moderate H2S release in vivo. In this work we report the design, synthesis, and biological evaluation of a new class of controllable H2S donors. Twenty-five donors were prepared and tested. Their structures were based on a perthiol template, which was suggested to be involved in H2S biosynthesis. H2S release mechanism from these donors was studied and proved to be thiol-dependent. We also developed a series of cell-based assays to access their H2S-related activities. H9c2 cardiac myocytes were used in these experiments. We tested lead donors' cytotoxicity and confirmed their H2S production in cells. Finally we demonstrated that selected donors showed potent protective effects in an in vivo murine model of myocardial ischemia-reperfusion injury, through a H2S-related mechanism.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fukuto, J. M., Carrington, S. J., Tantillo, D. J., Harrison, J. G., Ignarro, L. J., Freeman, B. A., Chen, A., & Wink, D. A. (2012) · Chemical Research in Toxicology · doi:10.1021/tx2005234 · Cited by 389
Filipovic, M. R., Miljkovic, J. L., Nauser, T., Royzen, M., Klos, K., Shubina, T., Koppenol, W. H., Lippard, S. J., & Ivanović-Burmazović, I. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3009693 · Cited by 336
The reaction of H2S with oxidized thiols: generation of persulfides and implications to H2S biology
Francoleon, N. E., Carrington, S. J., & Fukuto, J. M. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.09.015 · Cited by 199
Cited by
Chemical Biology of H2S Signaling through Persulfidation
Filipovic, M. R., Zivanovic, J., Alvarez, B., & Banerjee, R. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00205 · Cited by 1,046
A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications
Powell, C. R., Dillon, K. M., & Matson, J. B. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.11.014 · Cited by 599
Szabo, C., & Papapetropoulos, A. (2017) · Pharmacological Reviews · doi:10.1124/pr.117.014050 · Cited by 423
Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications
Zhao, Y., Biggs, T. D., & Xian, M. (2014) · Chem. Commun. · doi:10.1039/c4cc00968a · Cited by 358
Self-citationRole of hydrogen sulfide in health and disease
Jin, Y., Yuan, H., Liu, Y., Zhu, Y., Wang, Y., Liang, X., Gao, W., Ren, Z., Ji, X., & Wu, D. (2024) · MedComm · doi:10.1002/mco2.661 · Cited by 54
Metadata
- Authors
- Zhao, Y., Bhushan, S., Yang, C., Otsuka, H., Stein, J. D., Pacheco, A., Peng, B., Devarie-Baez, N. O., Aguilar, H. C., Lefer, D. J., & Xian, M.
- Venue
- ACS Chemical Biology
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-04-16
- Volume
- 8
- Issue
- 6
- Pages
- 1283-1290
- ISSN
- 1554-8929 (ISSN-L)
- 1554-8937
- OpenAlex
- W2133840693
- Cited by
- 170
- References
- 3
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Controllable Hydrogen Sulfide Donors and Their Activity against Myocardial Ischemia-Reperfusion Injury. https://app.cochat.ai/papers/10.1021/cb400090d
- The paper
- Zhao, Y., Bhushan, S., Yang, C., Otsuka, H., Stein, J. D., Pacheco, A., Peng, B., Devarie-Baez, N. O., Aguilar, H. C., Lefer, D. J., & Xian, M. (2013). Controllable Hydrogen Sulfide Donors and Their Activity against Myocardial Ischemia-Reperfusion Injury. ACS Chemical Biology. https://doi.org/10.1021/cb400090d
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
