The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Fast Dissolving Curcumin Cocrystals
Abstract
Curcumin is the principal curcuminoid of the popular Indian spice turmeric. Despite the diverse pharmacological activities of this bioactive phenol, its application as a drug is severely limited by poor aqueous solubility. We report novel cocrystals of curcumin ( 1 ) with resorcinol and pyrogallol obtained by liquid-assisted grinding. Curcumin–resorcinol ( 1a ) (1:1) and curcumin–pyrogallol ( 1b ) (1:1) were characterized by X-ray diffraction, thermal analysis, FT-IR, FT-Raman, and solid-state 13 C NMR spectroscopy. The 1:1 cocrystal stoichiometry is sustained by O–H···O hydrogen bonds between the phenolic OH groups of the coformers to the carbonyl group of curcumin. The melting point of the cocrystals is in between that of curcumin and the coformer and the lower melting cocrystal 1b is more soluble than higher melting 1a . The dissolution rates of curcumin–resorcinol ( 1a ) and curcumin–pyrogallol ( 1b ) in 40% EtOH–water are ∼5 and ∼12 times faster than that for curcumin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
OLEX2 : a complete structure solution, refinement and analysis program
Dolomanov, O. V., Bourhis, L. J., Gildea, R. J., Howard, J. A. K., & Puschmann, H. (2009) · Journal of Applied Crystallography · doi:10.1107/s0021889808042726 · Cited by 32,811
Bioavailability of curcumin: Problems and promises
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543
Amidon, G. L., Lennernäs, H., Shah, V. P., & Crison, J. R. (1995) · Pharmaceutical Research · doi:10.1023/a:1016212804288 · Cited by 5,430
Can the pharmaceutical industry reduce attrition rates?
Kola, I., & Landis, J. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1470 · Cited by 4,167
Cited by
Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications
Karimi-Jafari, M., Padrela, L., Walker, G. M., & Croker, D. M. (2018) · Crystal Growth & Design · doi:10.1021/acs.cgd.8b00933 · Cited by 667
Pharmaceutical cocrystals and poorly soluble drugs
Thakuria, R., Delori, A., Jones, W., Lipert, M. P., Roy, L., & Rodríguez-Hornedo, N. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.10.043 · Cited by 614
Eutectics as improved pharmaceutical materials: design, properties and characterization
Cherukuvada, S., & Nangia, A. (2014) · Chem. Commun. · doi:10.1039/c3cc47521b · Cited by 296
Self-citation
Metadata
- Authors
- Sanphui, P., Goud, N. R., Khandavilli, U. B. R., & Nangia, A.
- Venue
- Crystal Growth & Design
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-08-05
- Volume
- 11
- Issue
- 9
- Pages
- 4135-4145
- ISSN
- 1528-7483 (ISSN-L)
- 1528-7505
- OpenAlex
- W2318047941
- Cited by
- 253
- References
- 4
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
