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MCM-41 Organic Modification as Drug Delivery Rate Regulator

Muñoz, B., Rámila, A., Pérez-Pariente, J., Díaz, I., Vallet-Regí, M.·2003·Chemistry of Materials
DOI 10.1021/cm021217q
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Abstract

Organic modification with aminopropyl group of two MCM-41 materials having different pore sizes (obtained from trimethylalkylammonium surfactants with different chain sizes (16 and 12 carbon atoms)) has been carried out in order to control the delivery rate of ibuprofen from the siliceous matrix. This functionalization was performed by two different methods: the as-synthesized MCM-41 sample was treated with aminopropyltrimethoxysilane (method a ), and the MCM-41 was first calcined and then funtionalized by reaction with aminopropyltrimethoxysilane (method b ). The amount of ibuprofen adsorbed from hexane solution is lower for the C12 derived materials. A slower delivery rate has been observed for method b, whereas a minor influence of the pore size on the delivery rate has been found.

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Metadata

Authors
Muñoz, B., Rámila, A., Pérez-Pariente, J., Díaz, I., & Vallet-Regí, M.
Venue
Chemistry of Materials
Publisher
American Chemical Society (ACS)
Published
2002-12-21
Volume
15
Issue
2
Pages
500-503
ISSN
  • 0897-4756 (ISSN-L)
  • 1520-5002
DOI
10.1021/cm021217q
OpenAlex
W2085638225
Cited by
618
References
0
FWCI
10.76
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: MCM-41 Organic Modification as Drug Delivery Rate Regulator. https://app.cochat.ai/papers/10.1021/cm021217q
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Muñoz, B., Rámila, A., Pérez-Pariente, J., Díaz, I., & Vallet-Regí, M. (2003). MCM-41 Organic Modification as Drug Delivery Rate Regulator. Chemistry of Materials. https://doi.org/10.1021/cm021217q

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.