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In Vitro Sustained Release of LMWH from MgAl-layered Double Hydroxide Nanohybrids
Open accessAbstract
Magnesium-aluminum-chloride-layered double hydroxides (MgAl-Cl-LDHs) intercalated with low molecular weight heparin (LMWH) were prepared for the first time by the coprecipitation method and then characterized by XRD, elemental analysis, FTIR, SEM, and TEM. MgAl-LDH was studied as the drug carrier for LMWH, a widely used anticoagulant, in order to overcome some of its pharmaceutical limitations, such as its short half-life. In vitro release tests of LMWH-LDH in pH 7.4 PBS at 37 °C show a biphasic and sustained profile of LMWH anion release with ∼20% in the first 12 h and another ∼20% in the following 108 h. After release, the residue was characterized and dissolution−diffusion kinetic models fitted. The mechanism of MgAl-LMWH-LDH release is probably due to surface diffusion and bulk diffusion via anionic exchange of LMWH anions on or in the LDH with anions in the PBS solution.
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Cited by
Shao, M., Ning, F., Zhao, J., Wei, M., Evans, D. G., & Duan, X. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2086323 · Cited by 803
Ai, L., Zhang, C., & Meng, L. (2011) · Journal of Chemical & Engineering Data · doi:10.1021/je200743u · Cited by 283
Senapati, S., Thakur, R., Verma, S. P., Duggal, S., Mishra, D. P., Das, P., Shripathi, T., Kumar, M., Rana, D., & Maiti, P. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.016 · Cited by 155
Kumar, A., Schuerings, C., Kumar, S., Kumar, A., & Krishnan, V. (2018) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.9.62 · Cited by 153
Metadata
- Authors
- Gu, Z., Thomas, A. C., Xu, Z. P., Campbell, J. H., & Lu, G. Q. (.
- Venue
- Chemistry of Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-05-20
- Volume
- 20
- Issue
- 11
- Pages
- 3715-3722
- ISSN
- 0897-4756 (ISSN-L)
- 1520-5002
- OpenAlex
- W2086030168
- Cited by
- 257
- References
- 0
- FWCI
- 8.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Gu, Z., Thomas, A. C., Xu, Z. P., Campbell, J. H., & Lu, G. Q. (. (2008). In Vitro Sustained Release of LMWH from MgAl-layered Double Hydroxide Nanohybrids. Chemistry of Materials. https://doi.org/10.1021/cm703602t
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