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Cited by 259Metalloenzymes and iron-sulfur proteinsBiochemical Acid Research StudiesEnzyme Structure and Function

Pyruvate Ferredoxin Oxidoreductase and Its Radical Intermediate

Ragsdale, Stephen W.·2003·Chemical Reviews
DOI 10.1021/cr020423e
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Abstract

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyruvate Ferredoxin Oxidoreductase and Its Radical Intermediate†Stephen W. RagsdaleView Author Information Department of Biochemistry, Beadle Center, 19th and Vine Streets, University of Nebraska, Lincoln, Nebraska 68588-0664 Cite this: Chem. Rev. 2003, 103, 6, 2333–2346Publication Date (Web):April 8, 2003Publication History Received8 August 2002Published online8 April 2003Published inissue 1 June 2003https://doi.org/10.1021/cr020423eCopyright © 2003 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views3266Altmetric-Citations176LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (995 KB) Get e-AlertsSUBJECTS:Anions,Charge transfer,Cluster chemistry,Peptides and proteins,Transfer reactions Get e-Alerts

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  • Both abiotic and enzymatic reactions to pyruvate synthesis along the acetyl-CoA pathway are extremely O2-sensitive due to FeS clusters in electron transfer and other radical-generating reactions.

    “Second, both abiotic [90] and enzymatic reactions to pyruvate synthesis along the acetyl‐CoA pathway are extremely O2‐sensitive due to the involvement of FeS clusters in electron transfer and other radical‐generating reactions [91, 92]”

    From Evidence for corrin biosynthesis in the last universal common ancestor (2025) · cites this paper as [91]

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Authors
Ragsdale, S. W.
Affiliations
University of Nebraska–Lincoln (US)
Corresponding author
Ragsdale, Stephen W.
ORCID
Ragsdale, Stephen W.
Venue
Chemical Reviews
Publisher
American Chemical Society (ACS)
Published
2003-04-08
Volume
103
Issue
6
Pages
2333-2346
ISSN
  • 0009-2665 (ISSN-L)
  • 1520-6890
DOI
10.1021/cr020423e
OpenAlex
W2023913818
Cited by
259
References
1
Citations by year
2026: 12 · 2025: 20 · 2024: 23 · 2023: 21 · 2022: 10 · 2021: 15 · 2020: 13 · 2019: 12 · 2018: 8 · 2017: 16 · 2016: 10 · 2015: 10 · 2014: 11 · 2013: 6 · 2012: 3
FWCI
0.72
Type
journal article
Language
en
Open access
closed
Locations
  • Chemical Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of General Medical Sciences (GM-39451)
Topics
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Metalloenzymes and iron-sulfur proteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
  • Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
Keywords
pyruvate:ferredoxin oxidoreductase, radical intermediates, ferredoxin, pyruvate oxidation, electron transfer, iron-sulfur clusters, charge transfer, protein structure-function relationship
MeSH terms
Bacteria, Catalysis, Electron Transport, Free Radicals, Ketone Oxidoreductases, Models, Molecular, Molecular Structure, Pyruvate Synthase

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