The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
Abstract
The cytochromes P450 constitute a large family of cysteinato-heme enzymes, are present in all forms of life, and play a key role in the oxidative transformation of endogeneous and exogenous molecules. Isolation and characterization of these enzymes first occurred some 45 years ago. Up to the present, the exact nature of the active species responsible for the oxygen insertion step is still a matter of intensive debates. This review discusses the different steps of the catalytic cycle of cytochrome P450 with particular attention to the iron oxygen-containing intermediates. It also covers mechanistic aspects of reactions catalyzed by cytochrome P450 enzymes.
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Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
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Mammalian Microsomal Cytochrome P450 Monooxygenase
Williams, P. A., Cosme, J., Sridhar, V., Johnson, E. F., & McRee, D. E. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80408-6 · Cited by 696
Structure of a cytochrome P450-redox partner electron-transfer complex
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Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala
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Cited by
Structure and chemistry of cytochrome p450
Denisov, I. G., Makris, T. M., Sligar, S. G., & Schlichting, I. (2005) · Chemical Reviews · doi:10.1021/cr0307143 · Cited by 2,106
Proton-coupled electron transfer
Huynh, M. H. V., & Meyer, T. J. (2007) · Chemical Reviews · doi:10.1021/cr0500030 · Cited by 1,659
P450 Enzymes: Their Structure, Reactivity, and Selectivity—Modeled by QM/MM Calculations
Shaik, S., Cohen, S., Wang, Y., Chen, H., Kumar, D., & Thiel, W. (2010) · Chemical Reviews · doi:10.1021/cr900121s · Cited by 1,083
Self-citationJasniewski, A. J., & Que, L. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00457 · Cited by 474
Steroids, triterpenoids and molecular oxygen
Summons, R. E., Bradley, A. S., Jahnke, L. L., & Waldbauer, J. R. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1837 · Cited by 364
Metadata
- Authors
- Meunier, B., de Visser, S. P., & Shaik, S.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-08-21
- Volume
- 104
- Issue
- 9
- Pages
- 3947-3980
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2140158011
- Cited by
- 2,398
- References
- 4
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
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