The Lipophilic Bullet Hits the Targets: Medicinal Chemistry of Adamantane Derivatives

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Synthesis, structure–activity relationship, and p210bcr-abl protein tyrosine kinase activity of novel AG 957 analogs

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Organic blockers escape from trapping in the AMPA receptor channels by leaking into the cytoplasm

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Development and validation of a liquid chromatography–tandem mass spectrometry method for the determination of ST1926, a novel oral antitumor agent, adamantyl retinoid derivative, in plasma of patients in a Phase I study

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Synthesis, evaluation and application of polycyclic fluorescent analogues as N-methyl-d-aspartate receptor and voltage gated calcium channel ligands

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Selective blockade of Ca2+ permeable AMPA receptors in CA1 area of rat hippocampus

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Synthesis and antioxidant activity evaluation of novel antiparkinsonian agents, aminoadamantane derivatives of nitroxyl free radical

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Activation of Brain Histaminergic Neurotransmission: A Mechanism for Cognitive Effects of Memantine in Alzheimer’s Disease

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Memantine Inhibits ATP-Dependent K+ Conductances in Dopamine Neurons of the Rat Substantia Nigra Pars Compacta

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Synthesis of 1-Boraadamantaneamine Derivatives with Selective Astrocyte vs C6 Glioma Antiproliferative Activity. A Novel Class of Anti-Hepatitis C Agents with Potential to Bind CD81

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CD437, a synthetic retinoid, induces apoptosis in human respiratory epithelial cells via caspase-independent mitochondrial and caspase-8-dependent pathways both up-regulated by JNK signaling pathway

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CD437 induces apoptosis in ovarian adenocarcinoma cells via ER stress signaling

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Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-aminoadamantanes and analogues

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Negative Feedback Regulation of Nigrostriatal Dopamine Release: Mediation by Striatal D1 Receptors

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SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related molecule–mediated nuclear factor-κB activation, c-Fos/c-Jun expression, and cellular apoptosis

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Memantine and Functional Communication in Alzheimer's Disease: Results of a 12-Week, International, Randomized Clinical Trial

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Neuropeptide FF receptors antagonist, RF9, attenuates opioid-evoked hypothermia in mice

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Synthesis and biological evaluation of heterocycle containing adamantane 11β-HSD1 inhibitors

Yeh, V. S. C., Patel, J. R., Yong, H., Kurukulasuriya, R., Fung, S., Monzon, K., Chiou, W. J. H., Wang, J., Stolarik, D. F., Imade, H. M., et al. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.07.055 · Cited by 26

Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors

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Neuronal nicotinic receptors modulate synaptic function in the hippocampus and are sensitive to blockade by the convulsant strychnine and by the anti-Parkinson drug amantadine

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New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities

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Modulation of Survival Signaling Pathways and Persistence of the Genotoxic Stress as a Basis for the Synergistic Interaction between the Atypical Retinoid ST1926 and the Epidermal Growth Factor Receptor Inhibitor ZD1839

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Molecular Mechanism of Adaphostin-mediated G1 Arrest in Prostate Cancer (PC-3) Cells

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Incretin-based therapies in type 2 diabetes: A review of clinical results

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New synthesis of 6[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid and evaluation of the influence of adamantyl group on the DNA binding of a naphthoic retinoid

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Assessment of in Vitro and in Vivo Activities in the National Cancer Institute's Anticancer Screen with Respect to Chemical Structure, Target Specificity, and Mechanism of Action

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Discovery of orally active butyrolactam 11β-HSD1 inhibitors

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19F NMR detection of the complex between amantadine and the receptor portion of the influenza A M2 ion channel in DPC micelles

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A novel adamantane derivative attenuates retinal ischemia–reperfusion damage in the rat retina through σ1 receptors

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Design, Synthesis, and Pharmacological Characterization of Polyamine Toxin Derivatives: Potent Ligands for the Pore‐Forming Region of AMPA Receptors

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Developing a complete pharmacology for AMPA receptors: A perspective on subtype-selective ligands

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Discovery of novel inhibitors of human 11β-hydroxysteroid dehydrogenase type 1

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Involvement of thioredoxin‐binding protein 2 in the antitumor activity of CD437

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Chronic treatment with the uncompetitive NMDA receptor antagonist memantine influences the polyamine and glycine binding sites of the NMDA receptor complex in aged rats

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Heteroatom-Substituted Analogues of Orphan Nuclear Receptor Small Heterodimer Partner Ligand and Apoptosis Inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic Acid

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Efficacy of amantadine on quality of life in patients with chronic hepatitis C treated with interferon-α and ribavirin: results from a randomized, placebo-controlled, double-blind trial

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Apoptosis induced by synthetic retinoic acid CD437 on human melanoma A375 cells involves RIG-I pathway

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Adamantane derivatives: a new class of insulin secretagogues

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Adaphostin toxicity in a sensitive non-small cell lung cancer model is mediated through Nrf2 signaling and heme oxygenase 1

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Functional in vitro characterization of CR 3394: A novel voltage dependent N-methyl-d-aspartate (NMDA) receptor antagonist

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GADD45A is a mediator of CD437 induced apoptosis in ovarian carcinoma cells

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Antagonists of oxytocin featuring replacement with modified β‐mercaptopropionic acids at position 1

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Cholecystokinin CCK2receptors mediate the peptide's inhibitory actions on the contractile activity of human distal colon via the nitric oxide pathway

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Neuropeptide FF receptor antagonist, RF9, attenuates the fever induced by central injection of LPS in mice

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Suppression by memantine and amantadine of synaptic excitation intrastriatally evoked in rat neostriatal slices

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Modulation of the Production of Reactive Oxygen Species by Pre-Activated Neutrophils by Aminoadamantane Derivatives

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The Peptidomimetic, 1-Adamantyl-Substituted, and Flex-Het Classes of Retinoid-Derived Molecules: Their Structure-Activity Relationships and Retinoid Receptor-Independent Anticancer Activities

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Maximal adamantyl-substituted retinoid-related molecule-induced apoptosis requires NF-κB noncanonical and canonical pathway activation

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Amantadine increases striatal dopamine turnover in MPTP‐treated mice

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Proliferation-dependent induction of apoptosis by the retinoid CD437 in p53-mutated keratinocytes

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Transcriptional Profiling Identifies Altered Intracellular Labile Iron Homeostasis as a Contributing Factor to the Toxicity of Adaphostin: Decreased Vascular Endothelial Growth Factor Secretion Is Independent of Hypoxia-Inducible Factor-1 Regulation

Hose, C. D., Kaur, G., Sausville, E. A., & Monks, A. P. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0291 · Cited by 14

Crystal Structures of Dipeptides Containing the Dmt-Tic Pharmacophore

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Pharmacological characterization of the mouse NPFF2 receptor

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Carbon‐14 labeling of Saxagliptin (BMS‐477118)

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Involvement of ETS1 in thioredoxin-binding protein 2 transcription induced by a synthetic retinoid CD437 in human osteosarcoma cells

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Peginterferon ??-2a and ribavirin versus peginterferon ??-2a monotherapy in early virological responders and peginterferon ??-2a and ribavirin versus peginterferon ??-2a, ribavirin and amantadine triple therapy in early virological nonresponders: the SMIEC II trial in na??ve patients with chronic hepatitis C

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Mechanism of Action and Therapeutic Potential of Novel Adamantyl Retinoid-Related Molecules

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Synthesis and Biological Properties of Enkephalin‐like Peptides Containing Adamantylalanine in Position 4 and 5

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Adamantyl-Substituted Retinoid-Related Molecules Induce Apoptosis in Human Acute Myelogenous Leukemia Cells

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Common Binding Site for Externally and Internally Applied AMPA Receptor Channel Blockers

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The retinoid, 6-[3-adamantyl-4-hydroxyphenyl]-2-napthalene carboxylic acid, controls proliferative, morphological, and inflammatory responses involved in microglial activation without cytotoxic effects

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