The Lipophilic Bullet Hits the Targets: Medicinal Chemistry of Adamantane Derivatives

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1

Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00129-0 · Cited by 18,139

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(96)00423-1 · Cited by 11,385

Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94

Halgren, T. A. (1996) · Journal of Computational Chemistry · doi:10.1002/(sici)1096-987x(199604)17:5/6<490::aid-jcc1>3.0.co;2-p · Cited by 5,306

p53, guardian of the genome

Lane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138

The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes

Drucker, D. J., & Nauck, M. A. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69705-5 · Cited by 3,896

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975) · Nature · doi:10.1038/258577a0 · Cited by 3,806

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

Grundke-Iqbal, I., Iqbal, K., Tung, Y. C., Quinlan, M., Wisniewski, H. M., & Binder, L. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4913 · Cited by 3,676

Memantine in Moderate-to-Severe Alzheimer's Disease

Reisberg, B., Doody, R., Stöffler, A., Schmitt, F., Ferris, S., & Möbius, H. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa013128 · Cited by 2,043

Verteilung Von Noradrenalin Und Dopamin (3-Hydroxytyramin) Im Gehirn Des Menschen Und Ihr Verhalten Bei Erkrankungen Des Extrapyramidalen Systems

Ehringer, H., & Hornykiewicz, O. (1960) · Klinische Wochenschrift · doi:10.1007/bf01485901 · Cited by 1,867

Glutamate-mediated astrocyte–neuron signalling

Parpura, V., Basarsky, T. A., Liu, F., Jeftinija, K., Jeftinija, S., & Haydon, P. G. (1994) · Nature · doi:10.1038/369744a0 · Cited by 1,736

Virtual Computational Chemistry Laboratory – Design and Description

Tetko, I. V., Gasteiger, J., Todeschini, R., Mauri, A., Livingstone, D., Ertl, P., Palyulin, V. A., Radchenko, E. V., Zefirov, N. S., Makarenko, A. S., et al. (2005) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-005-8694-y · Cited by 1,500

The role of natural product chemistry in drug discovery

Butler, M. S. (2004) · Journal of Natural Products · doi:10.1021/np040106y · Cited by 1,381

Functional Repression of cAMP Response Element in 6-Hydroxydopamine-treated Neuronal Cells

Chalovich, E. M., Zhu, J.-H., Caltagarone, J., Bowser, R., & Chu, C. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602632200 · Cited by 1,371

3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists

CARLSSON, A., LINDQVIST, M., & MAGNUSSON, T. (1957) · Nature · doi:10.1038/1801200a0 · Cited by 1,278

Influenza virus M2 protein has ion channel activity

Pinto, L. H., Holsinger, L. J., & Lamb, R. A. (1992) · Cell · doi:10.1016/0092-8674(92)90452-i · Cited by 1,213

A SIMPLE PREPARATION OF ADAMANTANE

von R. Schleyer, P. (1957) · Journal of the American Chemical Society · doi:10.1021/ja01569a086 · Cited by 1,161

Memantine for dementia

McShane, R., Areosa Sastre, A., & Minakaran, N. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003154.pub5 · Cited by 1,155

Structure and mechanism of the M2 proton channel of influenza A virus

Schnell, J. R., & Chou, J. J. (2008) · Nature · doi:10.1038/nature06531 · Cited by 1,067

Tau pathology in Alzheimer disease and other tauopathies

Iqbal, K., del C. Alonso, A., Chen, S., Chohan, M. O., El-Akkad, E., Gong, C.-X., Khatoon, S., Li, B., Liu, F., Rahman, A., et al. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.09.008 · Cited by 1,037

Navigating chemical space for biology and medicine

Lipinski, C., & Hopkins, A. (2004) · Nature · doi:10.1038/nature03193 · Cited by 1,002

Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond

Lipton, S. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1958 · Cited by 909

Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa

Davies, P., Katzman, R., & Terry, R. D. (1980) · Nature · doi:10.1038/288279a0 · Cited by 882

Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist—a review of preclinical data

Parsons, C. G., Danysz, W., & Quack, G. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00019-2 · Cited by 878

KATP channels as molecular sensors of cellular metabolism

Nichols, C. G. (2006) · Nature · doi:10.1038/nature04711 · Cited by 851

The molecular basis of the specific anti-influenza action of amantadine.

Hay, A. J., Wolstenholme, A. J., Skehel, J. J., & Smith, M. H. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb04038.x · Cited by 847

Antiviral Activity of 1-Adamantanamine (Amantadine)

Davies, W. L., Grunert, R. R., Haff, R. F., McGahen, J. W., Neumayer, E. M., Paulshock, M., Watts, J. C., Wood, T. R., Hermann, E. C., & Hoffmann, C. E. (1964) · Science · doi:10.1126/science.144.3620.862 · Cited by 838

The promise of retinoids to fight against cancer

Altucci, L., & Gronemeyer, H. (2001) · Nature Reviews Cancer · doi:10.1038/35106036 · Cited by 773

Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern

Bright, R. A., Medina, M.-J., Xu, X., Perez-Oronoz, G., Wallis, T. R., Davis, X. M., Povinelli, L., Cox, N. J., & Klimov, A. I. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67338-2 · Cited by 725

Inhibition of Dipeptidyl Peptidase-4 Reduces Glycemia, Sustains Insulin Levels, and Reduces Glucagon Levels in Type 2 Diabetes

Ahrén, B., Landin-Olsson, M., Jansson, P.-A., Svensson, M., Holmes, D., & Schweizer, A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031907 · Cited by 710

Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse

Parsons, C. G., Stöffler, A., & Danysz, W. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.07.013 · Cited by 707

Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA

Comb, M., Seeburg, P. H., Adelman, J., Eiden, L., & Herbert, E. (1982) · Nature · doi:10.1038/295663a0 · Cited by 679

Amantadine in the Treatment of Parkinson's Disease

Schwab, R. S. (1969) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1969.03160070046011 · Cited by 664

The pharmacology of sigma-1 receptors.

Maurice, T., & Su, T.-P. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.07.001 · Cited by 654

Structural basis for the function and inhibition of an influenza virus proton channel

Stouffer, A. L., Acharya, R., Salom, D., Levine, A. S., Di Costanzo, L., Soto, C. S., Tereshko, V., Nanda, V., Stayrook, S., & DeGrado, W. F. (2008) · Nature · doi:10.1038/nature06528 · Cited by 636

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

Chen, H., Pellegrini, J., Aggarwal, S., Lei, S., Warach, S., Jensen, F., & Lipton, S. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04427.1992 · Cited by 629

Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Augeri, D. J., Robl, J. A., Betebenner, D. A., Magnin, D. R., Khanna, A., Robertson, J. G., Wang, A., Simpkins, L. M., Taunk, P., Huang, Q., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050261p · Cited by 624

Identification of an antimalarial synthetic trioxolane drug development candidate

Vennerstrom, J. L., Arbe-Barnes, S., Brun, R., Charman, S. A., Chiu, F. C. K., Chollet, J., Dong, Y., Dorn, A., Hunziker, D., Matile, H., et al. (2004) · Nature · doi:10.1038/nature02779 · Cited by 622

Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

Cady, S. D., Schmidt-Rohr, K., Wang, J., Soto, C. S., DeGrado, W. F., & Hong, M. (2010) · Nature · doi:10.1038/nature08722 · Cited by 615

1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: A Potent, Selective, and Orally Bioavailable Dipeptidyl Peptidase IV Inhibitor with Antihyperglycemic Properties

Villhauer, E. B., Brinkman, J. A., Naderi, G. B., Burkey, B. F., Dunning, B. E., Prasad, K., Mangold, B. L., Russell, M. E., & Hughes, T. E. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm030091l · Cited by 613

Isolation and Structure of Higher Diamondoids, Nanometer-Sized Diamond Molecules

Dahl, J. E., Liu, S. G., & Carlson, R. M. K. (2003) · Science · doi:10.1126/science.1078239 · Cited by 604

Nuclear transport of influenza virus ribonucleoproteins: The viral matrix protein (M1) promotes export and inhibits import

Martin, K., & Heleniust, A. (1991) · Cell · doi:10.1016/0092-8674(91)90576-k · Cited by 582

Opportunities in somatostatin research: biological, chemical and therapeutic aspects

Weckbecker, G., Lewis, I., Albert, R., Schmid, H. A., Hoyer, D., & Bruns, C. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1255 · Cited by 559

100 Years and Counting: Prospects for Defeating Alzheimer's Disease

Roberson, E. D., & Mucke, L. (2006) · Science · doi:10.1126/science.1132813 · Cited by 550

Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

Turski, L., Bressler, K., Jürgen Rettig, K., Löschmann, P.-A., & Wachtel, H. (1991) · Nature · doi:10.1038/349414a0 · Cited by 546

A Medicinal Chemistry Perspective on Artemisinin and Related Endoperoxides

O'Neill, P. M., & Posner, G. H. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm030571c · Cited by 538

Sulfonylurea Stimulation of Insulin Secretion

Proks, P., Reimann, F., Green, N., Gribble, F., & Ashcroft, F. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s368 · Cited by 510

The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine

Griffin, S. D. C., Beales, L. P., Clarke, D. S., Worsfold, O., Evans, S. D., Jaeger, J., Harris, M. P. G., & Rowlands, D. J. (2003) · FEBS Letters · doi:10.1016/s0014-5793(02)03851-6 · Cited by 497

Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block

Wang, C., Takeuchi, K., Pinto, L. H., & Lamb, R. A. (1993) · Journal of Virology · doi:10.1128/jvi.67.9.5585-5594.1993 · Cited by 494

Twelve- and 52-Week Efficacy of the Dipeptidyl Peptidase IV Inhibitor LAF237 in Metformin-Treated Patients With Type 2 Diabetes

Ahrén, B., Gomis, R., Standl, E., Mills, D., & Schweizer, A. (2004) · Diabetes Care · doi:10.2337/diacare.27.12.2874 · Cited by 487

The chemical biology of clinically tolerated NMDA receptor antagonists

Chen, H. V., & Lipton, S. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03991.x · Cited by 474

Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for delta opioid binding sites.

Erspamer, V, Melchiorri, P., Falconieri-Erspamer, G., Negri, L., Corsi, R., Severini, C., Barra, D., Simmaco, M., & Kreil, G. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.13.5188 · Cited by 464

The M2 Proton Channels of Influenza A and B Viruses

Pinto, L. H., & Lamb, R. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r500020200 · Cited by 459

Soluble epoxide hydrolase is a therapeutic target for acute inflammation

Schmelzer, K. R., Kubala, L., Newman, J. W., Kim, I.-H., Eiserich, J. P., & Hammock, B. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503279102 · Cited by 441

The Neuropharmacological Basis for the Use of Memantine in the Treatment of Alzheimer's Disease

Rogawski, M. A., & Wenk, G. L. (2003) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2003.tb00254.x · Cited by 436

Diamonds are a Chemist's Best Friend: Diamondoid Chemistry Beyond Adamantane

Schwertfeger, H., Fokin, A. A., & Schreiner, P. R. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200701684 · Cited by 413

Selective Alkane Transformations via Radicals and Radical Cations: Insights into the Activation Step from Experiment and Theory

Fokin, A. A., & Schreiner, P. R. (2002) · Chemical Reviews · doi:10.1021/cr000453m · Cited by 411

The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence

Danysz, W., & Parsons, C. G. (2003) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.938 · Cited by 404

Chemotherapy: targeting the mitochondrial cell death pathway

Debatin, K.-M., Poncet, D., & Kroemer, G. (2002) · Oncogene · doi:10.1038/sj.onc.1206039 · Cited by 396

Knockouts model the 100 best-selling drugs—will they model the next 100?

Zambrowicz, B. P., & Sands, A. T. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd987 · Cited by 393

Calcium Hypothesis of Alzheimer's Disease and Brain Aginga

KHACHATURIAN, Z. S. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb44398.x · Cited by 392

DPP-4 inhibitors and their potential role in the management of type 2 diabetes: DPP 4 INHIBITORS AND MANAGEMENT OF TYPE 2 DIABETES

BARNETT, A. (2006) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2006.01178.x · Cited by 391

The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives

Pavlović, D., Neville, D. C. A., Argaud, O., Blumberg, B., Dwek, R. A., Fischer, W. B., & Zitzmann, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1031527100 · Cited by 390

Calcium hypothesis of Alzheimer’s disease

Berridge, M. J. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0736-1 · Cited by 383

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

Charman, S. A., Arbe-Barnes, S., Bathurst, I. C., Brun, R., Campbell, M., Charman, W. N., Chiu, F. C. K., Chollet, J., Craft, J. C., Creek, D. J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015762108 · Cited by 373

11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice

Hermanowski-Vosatka, A., Balkovec, J. M., Cheng, K., Chen, H. Y., Hernandez, M., Koo, G. C., Le Grand, C. B., Li, Z., Metzger, J. M., Mundt, S. S., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050119 · Cited by 364

Viroporins

Gonzalez, M. E., & Carrasco, L. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00780-4 · Cited by 359

Synthesis, antimicrobial, and anti-HIV-1 activity of certain 5-(1-adamantyl)-2-substituted thio-1,3,4-oxadiazoles and 5-(1-adamantyl)-3-substituted aminomethyl-1,3,4-oxadiazoline-2-thiones

El-Emam, A. A., Al-Deeb, O. A., Al-Omar, M., & Lehmann, J. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.07.033 · Cited by 357

A functionally defined model for the M 2 proton channel of influenza A virus suggests a mechanism for its ion selectivity

Pinto, L. H., Dieckmann, G. R., Gandhi, C. S., Papworth, C. G., Braman, J., Shaughnessy, M. A., Lear, J. D., Lamb, R. A., & DeGrado, W. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11301 · Cited by 352

Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels

Bormann, J. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90385-3 · Cited by 351

GABA-Activated Ligand Gated Ion Channels: Medicinal Chemistry and Molecular Biology

Chebib, M., & Johnston, G. A. R. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm9904349 · Cited by 345

Human African trypanosomiasis: pharmacological re‐engagement with a neglected disease

Barrett, M. P., Boykin, D. W., Brun, R., & Tidwell, R. R. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707354 · Cited by 338

Human Neurons Express the Polyspecific Cation Transporter hOCT2, Which Translocates Monoamine Neurotransmitters, Amantadine, and Memantine

Busch, A. E., Karbach, U., Miska, D., Gorboulev, V., Akhoundova, A., Volk, C., Arndt, P., Ulzheimer, J. C., Sonders, M. S., Baumann, C., et al. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.2.342 · Cited by 332

Playing dirty

Frantz, S. (2005) · Nature · doi:10.1038/437942a · Cited by 322

Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents — preclinical studies

Danysz, W., Parsons, C. G., Kornhuber, J., Schmidt, W. J., & Quack, G. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00037-1 · Cited by 322

Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo

Parsons, C. G., Quack, G., Bresink, I., Baran, L., Przegalinski, E., Kostowski, W., Krzascik, P., Hartmann, S., & Danysz, W. (1995) · Neuropharmacology · doi:10.1016/0028-3908(95)00092-k · Cited by 311

The many faces of the adamantyl group in drug design

Liu, J., Obando, D., Liao, V., Lifa, T., & Codd, R. (2011) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2011.01.047 · Cited by 309

Improved Meal-Related β-Cell Function and Insulin Sensitivity by the Dipeptidyl Peptidase-IV Inhibitor Vildagliptin in Metformin-Treated Patients With Type 2 Diabetes Over 1Year

Ahrén, B., Pacini, G., Foley, J. E., & Schweizer, A. (2005) · Diabetes Care · doi:10.2337/diacare.28.8.1936 · Cited by 309

Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study

Kornhuber, J., Bormann, J., Hübers, M., Rusche, K., & Riederer, P. (1991) · European Journal of Pharmacology: Molecular Pharmacology · doi:10.1016/0922-4106(91)90113-v · Cited by 308

Dementia of Alzheimer’s disease and other neurodegenerative disorders—memantine, a new hope

Sonkusare, S. K., Kaul, C. L., & Ramarao, P. (2005) · Pharmacological Research · doi:10.1016/j.phrs.2004.05.005 · Cited by 307

Pharmacology of P2X channels

Gever, J. R., Cockayne, D. A., Dillon, M. P., Burnstock, G., & Ford, A. P. D. W. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0070-9 · Cited by 298

New medicines to improve control and contribute to the eradication of malaria

Wells, T. N. C., Alonso, P. L., & Gutteridge, W. E. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2972 · Cited by 298

Human immunodeficiency virus infection of CD4-bearing cells occurs by a pH-independent mechanism

McClure, M. O., Marsh, M., & Weiss, R. A. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02839.x · Cited by 295

Mechanism of drug inhibition and drug resistance of influenza A M2 channel

Pielak, R. M., Schnell, J. R., & Chou, J. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902548106 · Cited by 294

Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties.

Kornhuber, J., Weller, M., Schoppmeyer, K., & Riederer, P. (1994) · PubMed · Cited by 290

Pressor Attacks during Treatment with Monoamine-oxidase Inhibitors

(1965) · The Lancet · doi:10.1016/s0140-6736(65)91261-4 · Cited by 286

Patch clamp studies on the kinetics and selectivity of N-methyl-d-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)

Parsons, C. G., Gruner, R., Rozental, J., Millar, J., & Lodge, D. (1993) · Neuropharmacology · doi:10.1016/0028-3908(93)90029-3 · Cited by 279

The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006

Yu, C., Bruzek, L. M., Meng, X. W., Gores, G. J., Carter, C. A., Kaufmann, S. H., & Adjei, A. A. (2005) · Oncogene · doi:10.1038/sj.onc.1208841 · Cited by 277

Lack of Evidence for the Efficacy of Memantine in Mild Alzheimer Disease

Schneider, L. S. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.69 · Cited by 275

GABAA Receptor Channel Pharmacology

Johnston, G. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612054021024 · Cited by 274

Mg2+Imparts NMDA Receptor Subtype Selectivity to the Alzheimer's Drug Memantine

Kotermanski, S. E., & Johnson, J. W. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3703-08.2009 · Cited by 271

Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: Protection by memantine

Nath, A., Haughey, N. J., Jones, M., Anderson, C., Bell, J. E., & Geiger, J. D. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200002)47:2<186::aid-ana8>3.0.co;2-3 · Cited by 266

Neuroprotection by memantine against neurodegeneration induced by β-amyloid(1–40)

Miguel-Hidalgo, J. J., Alvarez, X. A., Cacabelos, R., & Quack, G. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03731-9 · Cited by 265

Specific structural alteration of the influenza haemagglutinin by amantadine.

Sugrue, R. J., Bahadur, G., Zambon, M. C., Hall-Smith, M., Douglas, A. R., & Hay, A. J. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07555.x · Cited by 264

An Orally Active Epoxide Hydrolase Inhibitor Lowers Blood Pressure and Provides Renal Protection in Salt-Sensitive Hypertension

Imig, J. D., Zhao, X., Zaharis, C. Z., Olearczyk, J. J., Pollock, D. M., Newman, J. W., Kim, I.-H., Watanabe, T., & Hammock, B. D. (2005) · Hypertension · doi:10.1161/01.hyp.0000176237.74820.75 · Cited by 257

The Molecular Basis of Memantine Action in Alzheimers Disease and Other Neurologic Disorders: Low-affinity, Uncompetitive Antagonism

Lipton, S. (2005) · Current Alzheimer Research · doi:10.2174/1567205053585846 · Cited by 256

Memantine in Moderate to Severe Alzheimer’s Disease: a Meta-Analysis of Randomised Clinical Trials

Winblad, B., Jones, R. W., Wirth, Y., Stöffler, A., & Möbius, H. J. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000102568 · Cited by 253

Memantine displaces [3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex

Kornhuber, J., Bormann, J., Retz, W., Hübers, M., & Riederer, P. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90384-1 · Cited by 253

Use of the Adamantane Structure in Medicinal Chemistry

Lamoureux, G., & Artavia, G. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710792065027 · Cited by 250

Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine.

Bores, G. M., Huger, F. P., Petko, W., Mutlib, A. E., Camacho, F., Rush, D. K., Selk, D. E., Wolf, V, Kosley, R. W., Davis, L., et al. (1996) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12928-5 · Cited by 248

The transmembrane domain of influenza A M2 protein forms amantadine-sensitive proton channels in planar lipid bilayers

Duff, K. C., & Ashley, R. H. (1992) · Virology · doi:10.1016/0042-6822(92)91239-q · Cited by 237

That Was Then But This Is Now: Malaria Research in the Time of an Eradication Agenda

Kappe, S. H. I., Vaughan, A. M., Boddey, J. A., & Cowman, A. F. (2010) · Science · doi:10.1126/science.1184785 · Cited by 237

Knowledge of the Proposed Chemical Mechanism of Action and Cytochrome P450 Metabolism of Antimalarial Trioxanes Like Artemisinin Allows Rational Design of New Antimalarial Peroxides

Posner, G. H., & O’Neill, P. M. (2004) · Accounts of Chemical Research · doi:10.1021/ar020227u · Cited by 237

THE CONTAMINATED DROP

(1965) · The Lancet · doi:10.1016/s0140-6736(65)91538-2 · Cited by 236

Sigma receptors: biology and therapeutic potential

Guitart, X., Codony, X., & Monroy, X. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1920-9 · Cited by 234

INVOLVEMENT OF NIGRO-STRIATAL NEURONS IN THE IN VIVO RELEASE OF DOPAMINE BY AMPHET-AMINE, AMANTADINE AND TYRAMINE

VON VOIGTLANDER, P. F., & MOORE, K. E. (1973) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)29444-7 · Cited by 233

Structure−Activity Relationship Studies on a Series of Novel, Substituted 1-Benzyl-5-phenyltetrazole P2X7Antagonists

Nelson, D. W., Gregg, R. J., Kort, M. E., Perez-Medrano, A., Voight, E. A., Wang, Y., Grayson, G., Namovic, M. T., Donnelly-Roberts, D. L., Niforatos, W., et al. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm051202e · Cited by 233

RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia

Simonin, F., Schmitt, M., Laulin, J.-P., Laboureyras, E., Jhamandas, J. H., MacTavish, D., Matifas, A., Mollereau, C., Laurent, P., Parmentier, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502090103 · Cited by 230

Susceptibility of highly pathogenic A(H5N1) avian influenza viruses to the neuraminidase inhibitors and adamantanes

Hurt, A. C., Selleck, P., Komadina, N., Shaw, R., Brown, L., & Barr, I. G. (2007) · Antiviral Research · doi:10.1016/j.antiviral.2006.10.004 · Cited by 230

N-Methyl-d-Aspartate Antagonists in the Treatment of Parkinson's Disease

Greenamyre, J. T., & O'Brien, C. F. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530210109030 · Cited by 226

Orally Bioavailable Potent Soluble Epoxide Hydrolase Inhibitors

Hwang, S. H., Tsai, H.-J., Liu, J.-Y., Morisseau, C., & Hammock, B. D. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm070270t · Cited by 225

Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer’s disease

Tanimukai, H., Grundke-Iqbal, I., & Iqbal, K. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62486-8 · Cited by 220

Biochemical and Pharmacological Activities of SR 142948A, a New Potent Neurotensin Receptor Antagonist

Gully, D., Labeeuw, B., Boigegrain, R., Oury-Donat, F., Bachy, A., Poncelet, M., Steinberg, R., Suaud-Chagny, M. F., Santucci, V., Vita, N., et al. (1997) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36482-1 · Cited by 218

Inhibition of Endosomal/Lysosomal Degradation Increases the Infectivity of Human Immunodeficiency Virus

Fredericksen, B. L., Wei, B. L., Yao, J., Luo, T., & Garcia, J. V. (2002) · Journal of Virology · doi:10.1128/jvi.76.22.11440-11446.2002 · Cited by 211

Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation

Raag, R., & Poulos, T. L. (1991) · Biochemistry · doi:10.1021/bi00224a016 · Cited by 210

Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells.

Sun, S., Yue, P., Dawson, M. I., Shroot, B., Michel, S., Lamph, W. W., Heyman, R. A., Teng, M., Chandraratna, R. A. S., Shudo, K., et al. (1997) · PubMed · Cited by 208

Influence of solubilizing environments on membrane protein structures

Cross, T. A., Sharma, M., Yi, M., & Zhou, H.-X. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.07.005 · Cited by 206

Influenza M2 proton channels

Pielak, R. M., & Chou, J. J. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.04.015 · Cited by 203

Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor γ

Bernard, B. A., Bernardon, J.-M., Delescluse, C., Martin, B., Lenoir, M.-C., Maignan, J., Charpentier, B., Pilgrim, W. R., Reichert, U., & Shroot, B. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90842-9 · Cited by 201

Memantine Blocks α7* Nicotinic Acetylcholine Receptors More Potently Than N-Methyl-D-aspartate Receptors in Rat Hippocampal Neurons

Aracava, Y., Pereira, E. F. R., Maelicke, A., & Albuquerque, E. X. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.077172 · Cited by 200

p53 independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells.

Shao, Z., Dawson, M. I., Li, X. S., Rishi, A. K., Sheikh, M. S., Han, Q., Ordóñez, J. V., Shroot, B., & Fontana, J. A. (1995) · PubMed · Cited by 198

Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437

Belzacq, A.-S., El Hamel, C., Vieira, H. L. A., Cohen, I., Haouzi, D., Métivier, D., Marchetti, P., Brenner, C., & Kroemer, G. (2001) · Oncogene · doi:10.1038/sj.onc.1204953 · Cited by 194

Backbone Structure of the Amantadine-Blocked Trans-Membrane Domain M2 Proton Channel from Influenza A Virus

Hu, J., Asbury, T., Achuthan, S., Li, C., Bertram, R., Quine, J. R., Fu, R., & Cross, T. A. (2007) · Biophysical Journal · doi:10.1529/biophysj.106.090183 · Cited by 194

Structure of Human Epoxide Hydrolase Reveals Mechanistic Inferences on Bifunctional Catalysis in Epoxide and Phosphate Ester Hydrolysis,

Gomez, G. A., Morisseau, C., Hammock, B. D., & Christianson, D. W. (2004) · Biochemistry · doi:10.1021/bi036189j · Cited by 186

Generation of Specific Deoxynojirimycin-type Inhibitors of the Non-lysosomal Glucosylceramidase

Overkleeft, H. S., Renkema, G. H., Neele, J., Vianello, P., Hung, I. O., Strijland, A., van der Burg, A. M., Koomen, G.-J., Pandit, U. K., & Aerts, J. M. F. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26522 · Cited by 186

Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: Results of a multicenter, randomized double-blind, controlled study

Thiboutot, D. M., Weiss, J., Bucko, A., Eichenfield, L., Jones, T., Clark, S., Liu, Y., Graeber, M., & Kang, S. (2007) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.06.006 · Cited by 183

Gaucher Disease-Associated Glucocerebrosidases Show Mutation-Dependent Chemical Chaperoning Profiles

Sawkar, A. R., Adamski-Werner, S. L., Cheng, W.-C., Wong, C.-H., Beutler, E., Zimmer, K.-P., & Kelly, J. W. (2005) · Chemistry & Biology · doi:10.1016/j.chembiol.2005.09.007 · Cited by 183

Pharmacodynamics of Memantine: An Update

Parsons, C., Rammes, G., & Danysz, W. (2008) · Current Neuropharmacology · doi:10.2174/157015908783769671 · Cited by 183

Soluble Epoxide Hydrolase Is a Main Effector of Angiotensin II–Induced Hypertension

Jung, O., Brandes, R. P., Kim, I.-H., Schweda, F., Schmidt, R., Hammock, B. D., Busse, R., & Fleming, I. (2005) · Hypertension · doi:10.1161/01.hyp.0000153792.29478.1d · Cited by 180

gp120 of HIV-1 induces apoptosis in rat cortical cell cultures: prevention by memantine

Müller, W. E. G., Schröder, H. C., Ushijima, H., Dapper, J., & Bormann, J. (1992) · European Journal of Pharmacology: Molecular Pharmacology · doi:10.1016/0922-4106(92)90063-2 · Cited by 179

The Adamantane-Derived Bananins Are Potent Inhibitors of the Helicase Activities and Replication of SARS Coronavirus

Tanner, J. A., Zheng, B.-J., Zhou, J., Watt, R. M., Jiang, J.-Q., Wong, K.-L., Lin, Y.-P., Lu, L.-Y., He, M.-L., Kung, H.-F., et al. (2005) · Chemistry & Biology · doi:10.1016/j.chembiol.2005.01.006 · Cited by 176

Emerging Influenza Antiviral Resistance Threats

Hayden, F. G., & de Jong, M. D. (2011) · Journal of Infectious Diseases · doi:10.1093/infdis/jiq012 · Cited by 176

Molecular Determinants of AHPN (CD437)-Induced Growth Arrest and Apoptosis in Human Lung Cancer Cell Lines

Li, Y., Lin, B., Agadir, A., Liu, R., Dawson, M. I., Reed, J. C., Fontana, J. A., Bost, F., Hobbs, P. D., Zheng, Y., et al. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.8.4719 · Cited by 175

Novel Neuroprotective Mechanisms of Memantine: Increase in Neurotrophic Factor Release from Astroglia and Anti-Inflammation by Preventing Microglial Activation

Wu, H.-M., Tzeng, N.-S., Qian, L., Wei, S.-J., Hu, X., Chen, S.-H., Rawls, S. M., Flood, P., Hong, J.-S., & Lu, R.-B. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.64 · Cited by 174

Amantadine treatment is an independent predictor of improved survival in Parkinson's disease

Uitti, R. J., Rajput, A. H., Ahlskog, J. E., Offord, K. P., Schroeder, D. R., Ho, M. M., Prasad, M., Rajput, A., & Basran, P. (1996) · Neurology · doi:10.1212/wnl.46.6.1551 · Cited by 171

The Global Portfolio of New Antimalarial Medicines Under Development

Olliaro, P., & Wells, T. (2009) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2009.51 · Cited by 168

Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study

Schifitto, G., Navia, B. A., Yiannoutsos, C. T., Marra, C. M., Chang, L., Ernst, T., Jarvik, J. G., Miller, E. N., Singer, E. J., Ellis, R. J., et al. (2007) · AIDS · doi:10.1097/qad.0b013e32813384e8 · Cited by 166

A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria

Griffin, S. D. C., Harvey, R., Clarke, D. S., Barclay, W. S., Harris, M., & Rowlands, D. J. (2004) · Journal of General Virology · doi:10.1099/vir.0.19634-0 · Cited by 166

Amantadine-Dopamine Interaction: Possible Mode of Action in Parkinsonism

Grelak, R. P., Clark, R., Stump, J. M., & Vernier, V. G. (1970) · Science · doi:10.1126/science.169.3941.203 · Cited by 166

A randomized, placebo-controlled study of memantine as adjunctive treatment in patients with schizophrenia

for the MEM-MD-29 Study Group, Lieberman, J. A., Papadakis, K., Csernansky, J., Litman, R., Volavka, J., Jia, X. D., & Gage, A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.200 · Cited by 162

Influenza B Virus BM2 Protein Has Ion Channel Activity that Conducts Protons across Membranes

Mould, J. A., Paterson, R. G., Takeda, M., Ohigashi, Y., Venkataraman, P., Lamb, R. A., & Pinto, L. H. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00190-4 · Cited by 160

The active oligomeric state of the minimalistic influenza virus M 2 ion channel is a tetramer

Sakaguchi, T., Tu, Q., Pinto, L. H., & Lamb, R. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5000 · Cited by 159

A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets

Kebabian, J. W., Britton, D. R., DeNinno, M. P., Perner, R. J., Smith, L. A., Jenner, P. G., Schoenleber, R. W., & Williams, M. J. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90556-j · Cited by 157

Synthesis and Antiviral Activity Evaluation of Some New Aminoadamantane Derivatives. 2

Kolocouris, N., Kolocouris, A., Foscolos, G. B., Fytas, G., Neyts, J. H., Padalko, E., Balzarini, J. M., Snoeck, R., Andreï, G., & Clercq, E. D. (1996) · Journal of Medicinal Chemistry · doi:10.1021/jm950891z · Cited by 157

Cerebrospinal fluid and serum concentrations of the N-methyl-d-aspartate (NMDA) receptor antagonist memantine in man

Kornhuber, J., & Quack, G. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11785-u · Cited by 156

Potential Antidepressive Properties of Amantadine, Memantine and Bifemelane

Moryl, E., Danysz, W., & Quack, G. (1993) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1993.tb01351.x · Cited by 156

Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration

Li, L., Sengupta, A., Haque, N., Grundke, I., & Iqbal, K. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.04.047 · Cited by 154

Memantine prevents HIV coat protein‐induced neuronal injury in vitro

Lipton, S. A. (1992) · Neurology · doi:10.1212/wnl.42.7.1403 · Cited by 152

NMR Detection of pH-Dependent Histidine–Water Proton Exchange Reveals the Conduction Mechanism of a Transmembrane Proton Channel

Hu, F., Schmidt‐Rohr, K., & Hong, M. (2011) · Journal of the American Chemical Society · doi:10.1021/ja2081185 · Cited by 152

Amantadine in Parkinson's disease

Crosby, N. J., Deane, K. H., & Clarke, C. E. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003468 · Cited by 151

Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by Adamantane derivatives

Magazanik, L. G., Buldakova, S., Samoilova, M., Гмиро, В. Е., Mellor, I. R., & Usherwood, P. N. R. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.655ba.x · Cited by 148

Molecular Dynamics Simulation Directed Rational Design of Inhibitors Targeting Drug-Resistant Mutants of Influenza A Virus M2

Wang, J., Ma, C., Fiorin, G., Carnevale, V., Wang, T., Hu, F., Lamb, R. A., Pinto, L. H., Hong, M., Klein, M. L., et al. (2011) · Journal of the American Chemical Society · doi:10.1021/ja204969m · Cited by 147

Amantadine for dyskinesia in Parkinson's disease

Crosby, N. J., Deane, K. H., & Clarke, C. E. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003467 · Cited by 146

Memantine reduces oxidative damage and enhances long-term recognition memory in aged rats

Dias, C. P., de Lima, M. N. M., Presti-Torres, J., Dornelles, A. D. S., Garcia, V. A., Scalco, F. S., Guimarães, M. R., Constantino, L. D. S., Budni, P., Dal‐Pizzol, F., et al. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.03.018 · Cited by 146

Regional Variations in the Pharmacology of NMDA Receptor Channel Blockers: Implications for Therapeutic Potential

Porter, R. H. P., & Greenamyre, J. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64020614.x · Cited by 146

Structure of Amantadine-Bound M2 Transmembrane Peptide of Influenza A in Lipid Bilayers from Magic-Angle-Spinning Solid-State NMR: The Role of Ser31 in Amantadine Binding

Cady, S. D., Mishanina, T. V., & Hong, M. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.11.022 · Cited by 146

Neuroprotection by NMDA Receptor Antagonists in a Variety of Neuropathologies

Palmer, G. C. (2001) · Current Drug Targets · doi:10.2174/1389450013348335 · Cited by 145

Isofagomine- and 2,5-Anhydro-2,5-imino- d -glucitol-Based Glucocerebrosidase Pharmacological Chaperones for Gaucher Disease Intervention

Yu, Z., Sawkar, A. R., Whalen, L. J., Wong, C., & Kelly, J. W. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm060677i · Cited by 144

Antagonists of the P2X7Receptor. From Lead Identification to Drug Development

Guile, S. D., Alcaraz, L., Birkinshaw, T. N., Bowers, K. C., Ebden, M. R., Furber, M., & Stocks, M. J. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm801528x · Cited by 142

The Adamantyl Group in Medicinal Agents. I. Hypoglycemic N-Arylsulfonyl-N'-adamantylureas

Gerzon, K., Krumkalns, E. V., Brindle, R. L., Marshall, F. J., & Root, M. A. (1963) · Journal of Medicinal Chemistry · doi:10.1021/jm00342a029 · Cited by 142

Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus†

Steinmann, E., Whitfield, T., Kallis, S., Dwek, R. A., Zitzmann, N., Pietschmann, T., & Bartenschlager, R. F. W. (2007) · Hepatology · doi:10.1002/hep.21686 · Cited by 141

Absorption, Metabolism, and Excretion of [14C]Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Humans

He, H., Tran, P., Yin, H., Smith, H. T., Batard, Y., Wang, L., Einolf, H. J., Gu, H., Mangold, J. B., Fischer, V., et al. (2008) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.023010 · Cited by 141

Pharmacology and chemistry of adapalene

Shroot, B., & Michel, S. (1997) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(97)70050-1 · Cited by 140

Treatment of Chronic Hepatitis C with Amantadine

Smith, J. P. (1997) · Digestive Diseases and Sciences · doi:10.1023/a:1018857314351 · Cited by 139

Differential behavioural and neurochemical effects of competitive and non-competitive NMDA receptor antagonists in rats

Bubser, M., Keseberg, U., Notz, P., & Schmidt, W. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90288-f · Cited by 138

Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine

Toggas, S. M., Masliah, E., & Mucke, L. (1996) · Brain Research · doi:10.1016/0006-8993(95)01197-8 · Cited by 137

Viral ion channels: structure and function

Fischer, W. B., & Sansom, M. S. P. (2002) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0304-4157(01)00009-0 · Cited by 135

Involvement of DPP‐IV catalytic residues in enzyme–saxagliptin complex formation

Metzler, W. J., Yanchunas, J., Weigelt, C. A., Kish, K., Klei, H. E., Xie, D., Zhang, Y., Corbett, M. J., Tamura, J. K., He, B., et al. (2008) · Protein Science · doi:10.1110/ps.073253208 · Cited by 132

Amantadine in Parkinson's Disease

Schwab, R. S. (1972) · JAMA · doi:10.1001/jama.1972.03210070026008 · Cited by 131

Comments on “Memantine Blocks α7* Nicotinic Acetylcholine Receptors More Potently Than N-Methyl-d-aspartate Receptors in Rat Hippocampal Neurons”

Banerjee, P., Samoriski, G., & Gupta, S. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.081976 · Cited by 131

In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models

Snyder, C., Chollet, J., Tomas, J. S., Scheurer, C., & Wittlin, S. (2006) · Experimental Parasitology · doi:10.1016/j.exppara.2006.09.016 · Cited by 130

Retinoid Induced Apoptosis in Leukemia Cells Through a Retinoic Acid Nuclear Receptor-Independent Pathway

Hsu, C. A., Rishi, A. K., Su-Li, X., Gerald, T. M., Dawson, M. I., Schiffer, C. A., Reichert, U., Shroot, B., Poirier, G. G., & Fontana, J. A. (1997) · Blood · doi:10.1182/blood.v89.12.4470 · Cited by 129

Heterocyclic rimantadine analogues with antiviral activity

Zoidis, G., Fytas, C., Papanastasiou, I. P., Foscolos, G. B., Fytas, G., Padalko, E. Y., Clercq, E. D., Naesens, L. M. J., Neyts, J. H., & Kolocouris, N. (2006) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2005.12.056 · Cited by 128

Dual Resistance to Adamantanes and Oseltamivir Among Seasonal Influenza A(H1N1) Viruses: 2008–2010

Sheu, T. G., Fry, A. M., Garten, R. J., Deyde, V., Shwe, T., Bullion, L., Peebles, P. J., Li, Y., Klimov, A. I., & Gubareva, L. V. (2010) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiq005 · Cited by 128

The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus.

Marchetti, P., Zamzami, N., Joseph, B., Schraen‐Maschke, S., Méreau-Richard, C., Costantini, P., Métivier, D., Susín, S. A., Kroemer, G., & Formstecher, P. (1999) · PubMed · Cited by 125

Involvement of in the abnormal hyperphosphorylation of tau and its reversal by Memantine

Chohan, M. O., Khatoon, S., Iqbal, I.-G., & Iqbal, K. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.06.021 · Cited by 125

Classical and novel retinoids: their targets in cancer therapy

Fontana, J. A., & Rishi, A. (2002) · Leukemia · doi:10.1038/sj.leu.2402414 · Cited by 125

Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel

Griffin, S. D. C., StGelais, C., Owsianka, A. M., Patel, A. H., Rowlands, D. J., & Harris, M. (2008) · Hepatology · doi:10.1002/hep.22555 · Cited by 124

Hit-to-Lead studies: The discovery of potent adamantane amide P2X7 receptor antagonists

Baxter, A., Bent, J., Bowers, K. C., Braddock, M., Brough, S., Fagura, M., Lawson, M., McInally, T., Mortimore, M., Robertson, M. J., et al. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2003.08.034 · Cited by 124

Synthesis, Structure-Affinity Relationships, and Biological Activities of Ligands Binding to Retinoic Acid Receptor Subtypes

Charpentier, B., Bernardon, J., Eustache, J., Millois, C., Martin, B., Michel, S., & Shroot, B. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00026a006 · Cited by 122

Amantadine-induced conformational and dynamical changes of the influenza M2 transmembrane proton channel

Cady, S. D., & Hong, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711500105 · Cited by 122

Synthetic Soluble Analogs of Galactosylceramide (GalCer) Bind to the V3 Domain of HIV-1 gp120 and Inhibit HIV-1-induced Fusion and Entry

Fantini, J., Hammache, D., Delézay, O., Yahi, N., André‐Barrès, C., Rico‐Lattes, I., & Lattes, A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.11.7245 · Cited by 121

Memantine agonist action at dopamine D2High receptors

Seeman, P. M., Caruso, C. M., & Lasaga, M. (2007) · Synapse · doi:10.1002/syn.20472 · Cited by 121

Mechanism of Transmitter Release: Voltage Hypothesis and Calcium Hypothesis

Zucker, R. S., & Lando, L. I. (1986) · Science · doi:10.1126/science.2868525 · Cited by 120

Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus

Wang, J., Qiu, J. X., Soto, C. S., & DeGrado, W. F. (2011) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2010.12.002 · Cited by 120

Alzheimer's disease drugs promote neurogenesis

Jin, K., Xie, L., Mao, X. O., & Greenberg, D. A. (2006) · Brain Research · doi:10.1016/j.brainres.2006.02.081 · Cited by 119

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Brandt, I., Joossens, J., Chen, X., Maes, M., Scharpé, S., Meester, I. D., & Lambeir, A. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.04.009 · Cited by 118

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Sun, S., Yue, P., Wu, G. S., El‐Deiry, W. S., Shroot, B., Hong, W. K., & Lotan, R. (1999) · Oncogene · doi:10.1038/sj.onc.1202543 · Cited by 118

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Nelson, M. I., Simonsen, L., Viboud, C. G., Miller, M. A., & Holmes, E. C. (2009) · Virology · doi:10.1016/j.virol.2009.03.026 · Cited by 117

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Kornhuber, J., Quack, G., Danysz, W., Jellinger, K. A., Danielczyk, W., Gsell, W., & Riederer, P. F. (1995) · Neuropharmacology · doi:10.1016/0028-3908(95)00056-c · Cited by 115

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Mow, B. M. F., Chandra, J., Svingen, P. A., Hallgren, C. G., Weisberg, E., Kottke, T. J., Narayanan, V. L., Litzow, M. R., Griffin, J. D., Sausville, E. A., et al. (2002) · Blood · doi:10.1182/blood.v99.2.664 · Cited by 115

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Parsons, C. G., Panchenko, V. A., Pinchenko, V. O., Tsyndrenko, A. Y., & Krishtal, O. A. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01228.x · Cited by 114

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Zang, Y., Beard, R. L., Chandraratna, R. A. S., & Kang, J. X. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400843 · Cited by 114

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Спасов, А. А., Khamidova, T. V., Бугаева, Л. И., & Morozov, I. (2000) · Pharmaceutical Chemistry Journal · doi:10.1007/bf02524549 · Cited by 111

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Dong, Y., Wittlin, S., Sriraghavan, K., Chollet, J., Charman, S. A., Charman, W. N., Scheurer, C., Urwyler, H., Tomas, J. S., Snyder, C., et al. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm901473s · Cited by 110

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Yang, X.-W., Grossman, R. B., & Xu, G. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00551 · Cited by 373

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Fresno, N., Pérez-Fernández, R., Goicoechea, C., Alkorta, I., Fernández-Carvajal, A., de la Torre-Martínez, R., Quirce, S., Ferrer-Montiel, A., Martín, M. I., Goya, P., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113841 · Cited by 22