Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

Alleviation of High-Fat Diet-Induced Fatty Liver Damage in Group IVA Phospholipase A2-Knockout Mice

Ii, H., Yokoyama, N., Yoshida, S., Tsutsumi, K., Hatakeyama, S., Sato, T., Ishihara, K., & Akiba, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008089 · Cited by 57

Increased PAFAH and Oxidized Lipids Are Associated With Inflammation and Atherosclerosis in Hypercholesterolemic Pigs

Keyzer, D. D., Karabina, S., Wei, W., Geeraert, B., Stengel, D., Marsillach, J., Camps, J., Holvoet, P., & Ninio, E. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.196592 · Cited by 57

Renal concentrating defect in mice lacking group IV cytosolic phospholipase A2

Downey, P., Sapirstein, A., O’Leary, E., Sun, T., Brown, D., & Bonventre, J. V. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.280.4.f607 · Cited by 57

Identification of a Domain That Mediates Association of Platelet-activating Factor Acetylhydrolase with High Density Lipoprotein

Gardner, A. A., Reichert, E. C., Topham, M. K., & Stafforini, D. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802394200 · Cited by 56

Group VIA Ca2+-independent phospholipase A2 (iPLA2β) and its role in β-cell programmed cell death

Lei, X., Barbour, S. E., & Ramanadham, S. (2010) · Biochimie · doi:10.1016/j.biochi.2010.01.005 · Cited by 55

Dual Roles of Endogenous Platelet-Activating Factor Acetylhydrolase in a Murine Model of Necrotizing Enterocolitis

Lu, J. N., Pierce, M., Franklin, A. D., Jilling, T., Stafforini, D. M., & Caplan, M. S. (2010) · Pediatric Research · doi:10.1203/pdr.0b013e3181eb2efe · Cited by 55

Bacterial cell membrane hydrolysis by secreted phospholipases A2: a major physiological role of human group IIa sPLA2 involving both bacterial cell wall penetration and interfacial catalysis

Buckland, A. G., Heeley, E. L., & Wilton, D. C. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00018-4 · Cited by 55

A novel phospholipase A2 associated with nuclear matrix: stimulation of the activity and modulation of the Ca2+ dependency by polyphosphoinositides

Tamiya‐Koizumi, K., Umekawa, H., Yoshida, S., ISHIHARA, H., & Kojima, K. (1989) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(89)90285-3 · Cited by 55

Ca2+-independent PLA2 controls endothelial store-operated Ca2+ entry and vascular tone in intact aorta

Boittin, F.-X., Gribi, F., Serir, K., & Bény, J. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00639.2008 · Cited by 54

Function, Activity, and Membrane Targeting of Cytosolic Phospholipase A2ζ in Mouse Lung Fibroblasts

Ghosh, M., Loper, R., Ghomashchi, F., Tucker, D. E., Bonventre, J. V., Gelb, M. H., & Leslie, C. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608458200 · Cited by 54

Attenuated Free Cholesterol Loading-induced Apoptosis but Preserved Phospholipid Composition of Peritoneal Macrophages from Mice That Do Not Express Group VIA Phospholipase A2

Bao, S. S., Li, Y., Lei, X., Wohltmann, M., Jin, W., Bohrer, A., Semenkovich, C. F., Ramanadham, S., Tabas, I. A., & TURK, J. W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701316200 · Cited by 54

Fatty acid amides: scooting mode-based discovery of tight-binding competitive inhibitors of secreted phospholipases A2

Jain, M. K., Ghomashchi, F., Yu, B.-Z., Bayburt, T. H., Murphy, D., Houck, D. R., Brownell, J., Reid, J. C. W., Solowiej, J. E., & Wong, S. C. (1992) · Journal of Medicinal Chemistry · doi:10.1021/jm00097a018 · Cited by 54

Analysis of expression of secreted phospholipases A2 in mouse tissues at protein and mRNA levels

Eerola, L. I., Surrel, F., Nevalainen, T. J., Gelb, M. H., Lambeau, G. J., & Laine, V. J. O. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.04.002 · Cited by 54

Cytosolic phospholipase A2 alpha inhibitor, pyrroxyphene, displays anti-arthritic and anti-bone destructive action in a murine arthritis model

宣之, 田., Kuwabara, K., Kobayashi, M., Yamada, K., Ono, T., Seno, K., Gahara, Y., Ishizaki, J., & Hori, Y. (2009) · Inflammation Research · doi:10.1007/s00011-009-0069-8 · Cited by 54

Highly Selective Hydrolysis of Fatty Acyl-CoAs by Calcium-independent Phospholipase A2β

Jenkins, C. M., Yan, W., Mancuso, D. J., & Gross, R. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511623200 · Cited by 54

Identification of the Expressed Form of Human Cytosolic Phospholipase A2β (cPLA2β)

Ghosh, M., Loper, R., Gelb, M. H., & Leslie, C. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601770200 · Cited by 53

Role of Calcium-independent Phospholipase A2β in High Glucose-induced Activation of RhoA, Rho Kinase, and CPI-17 in Cultured Vascular Smooth Muscle Cells and Vascular Smooth Muscle Hypercontractility in Diabetic Animals

Xie, Z., Gong, M. C., Su, W., Xie, D., TURK, J. W., & Guo, Z. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.057711 · Cited by 53

Regulation of Lysophospholipase Activity of the 85-kDa Phospholipase A2 and Activation in Mouse Peritoneal Macrophages

de Carvalho, M. G. S., Garritano, J., & Leslie, C. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.35.20439 · Cited by 53

The PLB2 Gene of Saccharomyces cerevisiae Confers Resistance to Lysophosphatidylcholine and Encodes a Phospholipase B/Lysophospholipase

Fyrst, H., Oskouian, B., Kuypers, F. A., & Saba, J. D. (1999) · Biochemistry · doi:10.1021/bi9824590 · Cited by 53

Inhibition of the complete set of mammalian secreted phospholipases A2 by indole analogues

Smart, B. P., Pan, Y. H., Weeks, A. K., Bollinger, J. G., Bahnson, B. J., & Gelb, M. H. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.01.022 · Cited by 52

Role of cytosolic phospholipase A2 in the production of lipid mediators and histamine release in mouse bone-marrow-derived mast cells

NAKATANI, N., Uozumi, N., Kume, K., et al. (2000) · Biochemical Journal · doi:10.1042/bj3520311 · Cited by 52

Annexin A6-induced Inhibition of Cytoplasmic Phospholipase A2 Is Linked to Caveolin-1 Export from the Golgi

Cubells, L., de Muga, S. V., Tebar, F., Bonventre, J. V., Balsinde, J., Pol, A., Grewal, T., & Enrich, C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706618200 · Cited by 51

Mechanism of Regulation of Group IVA Phospholipase A2 Activity by Ser727 Phosphorylation

Tian, W., Wijewickrama, G. T., Kim, J. H., Das, S., Tun, M. P., Gokhale, N., Jung, J. W., Kim, K. P., & Cho, W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707345200 · Cited by 51

Effect of Tryptophan Insertions on the Properties of the Human Group IIA Phospholipase A2: Mutagenesis Produces an Enzyme with Characteristics Similar to Those of the Human Group V Phospholipase A2

Beers, S. A., Buckland, A. G., Giles, N. M., Gelb, M. H., & Wilton, D. C. (2003) · Biochemistry · doi:10.1021/bi0343222 · Cited by 51

PLA2 (group IIA phospholipase A2) as a prognostic determinant in stage II colorectal carcinoma

Buhmeida, A. S., Bendardaf, R., Hilska, M., Laine, J., Collan, Y. U., Laato, M. K., Syrjänen, K. J., & Pyrhönen, S. O. (2009) · Annals of Oncology · doi:10.1093/annonc/mdn783 · Cited by 51

A Role for Lysosomal Phospholipase A2 in Drug Induced Phospholipidosis

Abe, A., Hiraoka, M., & Shayman, J. A. (2007) · Drug Metabolism Letters · doi:10.2174/187231207779814292 · Cited by 51

4-Alkoxybenzamidines as new potent phospholipase A2 inhibitors

Aitdafoun, M., Mounier, C. M., Heymans, F., Binisti, C., Bon, C., & Godfroid, J. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)02172-8 · Cited by 50

Sp1 Is Essential for p16INK4a Expression in Human Diploid Fibroblasts during Senescence

Wu, J., Xue, L., Weng, M., Sun, Y., Zhang, Z., Wang, W., & Tong, T. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000164 · Cited by 50

Group V and X secretory phospholipase A2 prevents adenoviral infection in mammalian cells

Mitsuishi, M., Masuda, S., Kudo, I., & Murakami, M. (2005) · Biochemical Journal · doi:10.1042/bj20050781 · Cited by 50

Local Expression of Platelet-Activating Factor-Acetylhydrolase Reduces Accumulation of Oxidized Lipoproteins and Inhibits Inflammation, Shear Stress-Induced Thrombosis, and Neointima Formation in Balloon-Injured Carotid Arteries in Nonhyperlipidemic Rabbits

Arakawa, H., Qian, J.-Y., Baatar, D., Karasawa, K., Asada, Y., Sasaguri, Y., Miller, E. R., Witztum, J. L., & Ueno, H. (2005) · Circulation · doi:10.1161/circulationaha.104.476242 · Cited by 50

Calcium Binding Rigidifies the C2 Domain and the Intradomain Interaction of GIVA Phospholipase A2 as Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry

Hsu, Y., Burke, J. E., Stephens, D. L., Deems, R. A., Li, S., Asmus, K., Woods, V. L., & Dennis, E. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708143200 · Cited by 50

Anionic lipids activate group IVA cytosolic phospholipase A2 via distinct and separate mechanisms

Subramanian, P., Vora, M., Gentile, L. B., Stahelin, R. V., & Chalfant, C. E. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700356-jlr200 · Cited by 50

The class II tumour suppressor gene H-REV107-1 is a target of interferon-regulatory factor-1 and is involved in IFNγ-induced cell death in human ovarian carcinoma cells

Sers, C., Husmann, K., Nazarenko, I. A., Reich, S., Wiechen, K., Zhumabayeva, B., Adhikari, P., Schröder, K., Gontarewicz, A., & Schäfer, R. (2002) · Oncogene · doi:10.1038/sj.onc.1205377 · Cited by 50

Discovery of new non-phospholipid inhibitors of the secretory phospholipases A2

Beaton, H. G., Bennion, C., Connolly, S., Cook, A. R., Gensmantel, N. P., Hallam, C. N., Hardy, K., HITCHIN, B. W., Jackson, C. G., & ROBINSON, D. H. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00031a001 · Cited by 49

Identification and distribution of endoplasmic reticulum iPLA2

Kinsey, G. R., Cummings, B. S., Beckett, C. S., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.12.016 · Cited by 49

Lysis of Human Immunodeficiency Virus Type 1 by a Specific Secreted Human Phospholipase A2

Kim, J.-O., Chakrabarti, B. K., Guha-Niyogi, A., Louder, M. K., Mascola, J. R., Lakshmanan, G., & Nabel, G. J. (2006) · Journal of Virology · doi:10.1128/jvi.01790-06 · Cited by 48

Indole Inhibitors of Human Nonpancreatic Secretory Phospholipase A2. 2. Indole-3-acetamides with Additional Functionality

Dillard, R. D., Bach, N. J., Draheim, S. E., Berry, D. R., Carlson, D. G., Chirgadze, N. Y., Clawson, D. K., Hartley, L. W., Johnson, L. M., Jones, N. D., et al. (1996) · Journal of Medicinal Chemistry · doi:10.1021/jm960486n · Cited by 48

Carriage of the V279F Null Allele within the Gene Encoding Lp-PLA2 Is Protective from Coronary Artery Disease in South Korean Males

Jang, Y., Waterworth, D. M., Lee, J.-E., Song, K. S., Kim, S., Kim, H.-S., Park, K. W., Cho, H., Oh, I., Park, J. E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018208 · Cited by 47

Localization and function of cytosolic phospholipase A2α at the Golgi

Leslie, C. C., Gangelhoff, T. A., & Gelb, M. H. (2010) · Biochimie · doi:10.1016/j.biochi.2010.03.001 · Cited by 47

Expression of secretory phospholipase A2 in colon tumor cells potentiates tumor growth

Belinsky, G. S., Rajan, T. V., Saria, E. A., Giardina, C. A., & Rosenberg, D. W. (2006) · Molecular Carcinogenesis · doi:10.1002/mc.20271 · Cited by 47

Critical role of a hydrogen bond in the interaction of phospholipase A2 with transition-state and substrate analogues.

Yu, L., & Dennis, E. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.9325 · Cited by 47

Involvement of Group VIA Calcium-Independent Phospholipase A2 in Macrophage Engulfment of Hydrogen Peroxide-Treated U937 Cells

Pérez, R., Balboa, M. A., & Balsinde, J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2555 · Cited by 46

cPLA2 Regulates the Expression of Type I Interferons and Intracellular Immunity to Chlamydia trachomatis

Vignola, M. J., Kashatus, D. F., Taylor, G. A., Counter, C. M., & Valdivia, R. H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.103010 · Cited by 46

Group X Secretory Phospholipase A 2 Negatively Regulates ABCA1 and ABCG1 Expression and Cholesterol Efflux in Macrophages

Shridas, P., Bailey, W. M., Gizard, F., Oslund, R., Gelb, M. H., Bruemmer, D., & Webb, N. R. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.210237 · Cited by 46

Cytosolic Phospholipase A2-α Mediates Endothelial Cell Proliferation and Is Inactivated by Association with the Golgi Apparatus

Herbert, S. P., Ponnambalam, S., & Walker, J. H. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-02-0164 · Cited by 46

Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors

Im, D. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.135 · Cited by 46

Relationship of lipoprotein-associated phospholipase A2 and oxidized low density lipoprotein in carotid atherosclerosis

Vickers, K. C., Maguire, C. T., Wolfert, R. L., Burns, A. R., Reardon, M. J., Geis, R., Holvoet, P., & Morrisett, J. D. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800342-jlr200 · Cited by 45

Calcium‐independent phospholipase A2 mediates proliferation of human promonocytic U937 cells

Balboa, M. A., Pérez, R., & Balsinde, J. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06350.x · Cited by 45

Interfacial Binding of Bee Venom Secreted Phospholipase A2 to Membranes Occurs Predominantly by a Nonelectrostatic Mechanism

Bollinger, J. G., Diraviyam, K., Ghomashchi, F., Murray, D., & Gelb, M. H. (2004) · Biochemistry · doi:10.1021/bi049390i · Cited by 45

Differential determination of phospholipase A2 and PAF-acetylhydrolase in biological fluids using fluorescent substrates

Kitsiouli, E., Nakos, G., & Lekka, M. E. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32110-6 · Cited by 45

Secreted phospholipases A2: A proinflammatory connection between macrophages and mast cells in the human lung

Granata, F., Nardicchi, V., Loffredo, S., Frattini, A., Staiano, R. I., Agostini, C., & Triggiani, M. (2009) · Immunobiology · doi:10.1016/j.imbio.2009.06.006 · Cited by 44

NAD(P)H oxidase-mediated reactive oxygen species production alters astrocyte membrane molecular order via phospholipase A2

Zhu, D., Hu, C., Sheng, W., Tan, K. S., Haidekker, M. A., Sun, A. Y., Sun, G. Y., & Lee, J. C. (2009) · Biochemical Journal · doi:10.1042/bj20090356 · Cited by 44

Impact of a Soluble Phospholipase A2Inhibitor on Inhaled Allergen Challenge in Subjects with Asthma

Bowton, D. L., Dmitrienko, A. A., Israel, E., Zeiher, B. G., & Sides, G. D. (2005) · Journal of Asthma · doi:10.1081/jas-200044748 · Cited by 43

Scalaradial, a Dialdehyde‐Containing Marine Metabolite That Causes an Unexpected Noncovalent PLA2 Inactivation

Monti, M. C., Casapullo, A., Cavasotto, C. N., Napolitano, A., & Riccio, R. (2007) · ChemBioChem · doi:10.1002/cbic.200700217 · Cited by 42

Reduction of cPLA2α overexpression: An efficient anti‐inflammatory therapy for collagen‐induced arthritis

Raichel, L., Berger, S., Hadad, N., Kachko, L., Karter, M., Szaingurten‐Solodkin, I., Williams, R. O., Feldmann, M., & Lévy, R. (2008) · European Journal of Immunology · doi:10.1002/eji.200838545 · Cited by 42

Group VIA Phospholipase A2 Forms a Signaling Complex with the Calcium/Calmodulin-dependent Protein Kinase IIβ Expressed in Pancreatic Islet β-Cells

Wang, Z., Ramanadham, S., Ma, Z. A., Bao, S. S., Mancuso, D. J., Gross, R. W., & TURK, J. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405287200 · Cited by 42

Group IB Secretory Phospholipase A2 Stimulates CXC Chemokine Ligand 8 Production via ERK and NF-κB in Human Neutrophils

Jo, E., Lee, H., Lee, Y.-N., Kim, J. I., Kang, H., Park, D., Baek, S., Kwak, J., & Bae, Y. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.10.6433 · Cited by 42

Extracellular phospholipases in atherosclerosis

Karabina, S., Gora, S., Atout, R., & Ninio, E. (2010) · Biochimie · doi:10.1016/j.biochi.2010.02.002 · Cited by 41

Mechanism of Inhibition of LDL Phospholipase A2 by Monocyclic-β-lactams. Burst Kinetics and the Effect of Stereochemistry

Tew, D. G., Boyd, H., Ashman, S. M., Theobald, C. J., & Leach, C. A. (1998) · Biochemistry · doi:10.1021/bi9801412 · Cited by 41

Structure and function of lysosomal phospholipase A2: identification of the catalytic triad and the role of cysteine residues

Hiraoka, M., Abe, A., & Shayman, J. A. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500248-jlr200 · Cited by 41

Golgi-associated cPLA2α Regulates Endothelial Cell–Cell Junction Integrity by Controlling the Trafficking of Transmembrane Junction Proteins

Regan‐Klapisz, E., Krouwer, V. J. D., Langelaar‐Makkinje, M., Nallan, L., Gelb, M. H., Gerritsen, H. C., Verkleij, A. J., & Post, J. A. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-02-0210 · Cited by 41

The discovery of SB-435495

Blackie, J. A., Bloomer, J. C., Brown, M. J. B., Cheng, H., Elliott, R. L., Hammond, B., Hickey, D. M. B., Ife, R. J., Leach, C. A., Lewis, V. A., et al. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(02)00473-0 · Cited by 41

Further insights on the structural aspects of PLA2 inhibition by γ-hydroxybutenolide-containing natural products: a comparative study on petrosaspongiolides M–R

Monti, M. C., Casapullo, A., Riccio, R., et al. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2003.12.038 · Cited by 40

Cytosolic Phospholipase A2 Activation Correlates with HER2 Overexpression and Mediates Estrogen-Dependent Breast Cancer Cell Growth

Caiazza, F., Harvey, B. J., & Thomas, W. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0293 · Cited by 40

The patatin-like lipase family in Gallus gallus

Saarela, J., Jung, G., Hermann, M., Nimpf, J., & Schneider, W. J. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-281 · Cited by 40

Primary structure of protein moiety of Penicillium notatum phospholipase B deduced from the cDNA

Masuda, N., Kitamura, N., & Saito, K. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16433.x · Cited by 40

The effect of inhibition of Ca2+-independent phospholipase A2 on chemotherapeutic-induced death and phospholipid profiles in renal cells

Zhang, L., Peterson, B. L., & Cummings, B. S. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.09.008 · Cited by 39

Phospholipase A2 inhibition and atherosclerotic vascular disease: prospects for targeting secretory and lipoprotein-associated phospholipase A2 enzymes

Rosenson, R. S. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32833eb581 · Cited by 39

Human Platelets Secrete the Plasma Type of Platelet-Activating Factor Acetylhydrolase Primarily Associated With Microparticles

Mitsios, J. V., Vini, M. P., Stengel, D., Ninio, E., & Tselepis, A. D. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000228821.79588.ef · Cited by 39

Postsynaptic injection of calcium‐independent phospholipase A2 inhibitors selectively increases AMPA receptor‐mediated synaptic transmission

St-Gelais, F., Ménard, C., Congar, P., Trudeau, L., & Massicotte, G. (2004) · Hippocampus · doi:10.1002/hipo.10176 · Cited by 39

Calcium‐independent phospholipase A2‐mediated formation of 1,2‐diarachidonoyl‐glycerophosphoinositol in monocytes

Balgoma, D., Montero, O., Balboa, M. A., et al. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06742.x · Cited by 38

The role of cytosolic phospholipase A2-alfa in regulation of phagocytic functions

Lévy, R. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.09.004 · Cited by 38

1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A2α and fatty acid amide hydrolase

Forster, L., Ludwig, J., Kaptur, M., Bovens, S., Elfringhoff, A. S., Holtfrerich, A., & Lehr, M. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.11.028 · Cited by 38

The Binding Mode of Petrosaspongiolide M to the Human Group IIA Phospholipase A2: Exploring the Role of Covalent and Noncovalent Interactions in the Inhibition Process

Monti, M. C., Casapullo, A., Cavasotto, C. N., Tosco, A., Piaz, F. D., Žiemys, A., Margarucci, L., & Riccio, R. (2008) · Chemistry - A European Journal · doi:10.1002/chem.200801512 · Cited by 38

Cooperation Between Secretory Phospholipase A 2 and TNF-Receptor Superfamily Signaling

Fuentes, L., Hernández, M., Fernández-Avilés, F. J., Crespo, M. S., & Nieto, M. L. (2002) · Circulation Research · doi:10.1161/01.res.0000038341.34243.64 · Cited by 38

Lipoprotein-Associated Phospholipase A2 Interacts with Phospholipid Vesicles via a Surface-Disposed Hydrophobic α-Helix

Cao, J., Hsu, Y., Li, S., Woods, V. L., & Dennis, E. A. (2011) · Biochemistry · doi:10.1021/bi101916w · Cited by 38

High-Affinity Aptamers Selectively Inhibit Human Nonpancreatic Secretory Phospholipase A2 (hnps-PLA2)

Bridonneau, P., Chang, Y.-F., O'Connell, D., Gill, S. C., Snyder, D. W., Johnson, L. M., Goodson, T. G., III, Herron, D. K., & Parma, D. H. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm970579k · Cited by 36

Effects of Biological Oxidants on the Catalytic Activity and Structure of Group VIA Phospholipase A2

Song, H., Bao, S. S., Ramanadham, S., & TURK, J. W. (2006) · Biochemistry · doi:10.1021/bi060502a · Cited by 36

Effects of pyrrophenone, an inhibitor of group IVA phospholipase A 2 , on eicosanoid and PAF biosynthesis in human neutrophils

Flamand, N., Picard, S., Lemieux, L., et al. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706879 · Cited by 36

Interfacial Kinetic and Binding Properties of Mammalian Group IVB Phospholipase A2 (cPLA2β) and Comparison with the Other cPLA2 Isoforms

Ghomashchi, F., Naika, G. S., Bollinger, J. G., Aloulou, A., Lehr, M., Leslie, C. C., & Gelb, M. H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.165647 · Cited by 36

Metabolic Syndrome and Carotid Intima-Media Thickness in Young Adults: Roles of Apolipoprotein B, Apolipoprotein A-I, C-Reactive Protein, and Secretory Phospholipase A2: The Cardiovascular Risk in Young Finns Study

Mattsson, N., Magnussen, C. G., Rönnemaa, T., Mallat, Z., Bénessiano, J., Jula, A., Taittonen, L. M., Kähönen, M. A. P., Juonala, M., Viikari, J. S. A., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.204669 · Cited by 36

Association of cPLA2-α and COX-1 with the Golgi apparatus of A549 human lung epithelial cells

Grewal, S., Ponnambalam, S., & Walker, J. H. (2003) · Journal of Cell Science · doi:10.1242/jcs.00446 · Cited by 35

Novel splice‐site mutations and a large intragenic deletion in PLA2G6 associated with a severe and rapidly progressive form of infantile neuroaxonal dystrophy

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