PPARs and lipid ligands in inflammation and metabolism
Harmon, Gregory S., Lam, Michael T., Glass, Christopher K.·2011·Chemical Reviews
Cited by (224)
Items 101–200 of 224
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- A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivitySabina Sblano, Carmen Cerchia, Antonio Laghezza, Luca Piemontese, Leonardo Brunetti, Rosalba Leuci, Federica Gilardi, Aurélien Thomas, Massimo Genovese, Alice Santi et al. · 2022 · European Journal of Medicinal Chemistry
- Gene expression of adipose tissue, endothelial cells and platelets in subjects with metabolic syndrome (Review)Iván F. Palomo · 2012 · Molecular Medicine Reports
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- Discovery of Pan-peroxisome Proliferator-Activated Receptor Modulators from an Endolichenic Fungus, Daldinia childiaeJaekyeong Kim, Hyejin Ko, Jae–Seoun Hur, Seungchan An, Jin Woo Lee, Stephen T. Deyrup, Minsoo Noh, Sang Hee Shim · 2022 · Journal of Natural Products
- The PPARΩPocket: Renewed Opportunities for Drug DevelopmentÅsmund Kaupang, Trond Vidar Hansen · 2020 · PPAR Research
- A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier InhibitionAntonio Laghezza, Carmen Cerchia, Massimo Genovese, Rosalba Leuci, Erica Pranzini, Alice Santi, Leonardo Brunetti, Luca Piemontese, Paolo Tortorella, Abanish Biswas et al. · 2023 · Journal of Medicinal Chemistry
- Prenylated Chrysin Derivatives as Partial PPARγ Agonists with Adiponectin Secretion-Inducing ActivitySeungchan An, Hyejin Ko, Hongjun Jang, In Guk Park, Sungjin Ahn, Seok Young Hwang, Junpyo Gong, Soyeon Oh, Soo Yeon Kwak, Yeonjin Lee et al. · 2023 · ACS Medicinal Chemistry Letters
- Neferine alleviates acute kidney injury by regulating the PPAR-α/NF-κB pathwayYanying Xiong, Jin Zhong, Wenhang Chen, Xuan Li, Hong Shu Liu, Ying Li, Weijian Xiong, Huihui Li · 2024 · Clinical and Experimental Nephrology
- Defective expression of the peroxisome regulators PPARα receptors and lysogenesis with increased cellular senescence in the venous wall of chronic venous disorder.Miguel Angel Ortega, Oscar Fraile‐Μartinez, Leonel Pekarek, Miguel Ángel Álvarez-Mon, Ángel Asúnsolo, Lara Sánchez‐Trujillo, Santiago Coca, Julia Buján, Melchor Álvarez‐Mon, Natalio García‐Honduvilla et al. · 2021 · PubMed
- Peroxisome Proliferator-activated Receptor-γ As A Novel and Promising Target For Treating Cancer Via Regulation of Inflammation: A Brief ReviewS. Yuvaraj, B. R. Prashantha Kumar · 2021 · Mini-Reviews in Medicinal Chemistry
- Identifying the Metabolic Signatures of PPARD-Overexpressing Gastric TumorsShivanand Pudakalakatti, Mark Anton Titus, José S. Enriquez, Sumankalai Ramachandran, Niki Marie Zacharias, Imad Shureiqi, Yi Liu, James C. Yao, Xiangsheng Zuo, Pratip K. Bhattacharya · 2022 · International Journal of Molecular Sciences
- Exploring Novel Therapeutics for Pulmonary Arterial HypertensionTakayuki Fujiwara, Satoshi Ishii, Shun Minatsuki, Masaru Hatano, Norifumi Takeda · 2025 · International Heart Journal
- Computational Prediction of the Phenotypic Effect of Flavonoids on Adiponectin BiosynthesisSeungchan An, Seok Young Hwang, Junpyo Gong, Sungjin Ahn, In Guk Park, Soyeon Oh, Young‐Won Chin, Minsoo Noh · 2023 · Journal of Chemical Information and Modeling
- CES1 Releases Oxylipins from Oxidized Triacylglycerol (oxTAG) and Regulates Macrophage oxTAG/TAG Accumulation and PGE2/IL-1β ProductionMaggie E. Phillips, Oluwabori Adekanye, Abdolsamad Borazjani, John Allen Crow, Matthew K. Ross · 2023 · ACS Chemical Biology
- Effect of chiglitazar and sitagliptin on glucose variations, insulin resistance and inflammatory-related biomarkers in untreated patients with type 2 diabetesYuming Wang, Huiqin Li, Hui Gao, Xiaohua Xu, Tingting Cai, Huiying Wang, Yunting Zhou, Rong Huang, Xiaofei Su, Jiahuan Ma · 2021 · Diabetes Research and Clinical Practice
- Harnessing conserved signaling and metabolic pathways to enhance the maturation of functional engineered tissuesNeal I. Callaghan, Lauren J. Durland, Ronald G. Ireland, J. Paul Santerre, Craig A. Simmons, Locke Davenport Huyer · 2022 · npj Regenerative Medicine
- Design, synthesis, and biological evaluation of piperazine derivatives as pan-PPARs agonists for the treatment of liver fibrosisGang Sun, Zhiqi Feng, Yufan Kuang, Zhuoxin Fu, Yanyan Wang, Xing Zhao, Fengqin Wang, Hongbin Sun, Haoliang Yuan, Liang Xiang Dai · 2024 · European Journal of Medicinal Chemistry
- Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618Åsmund Kaupang, Steinar Martin Paulsen, Calin Constantin Steindal, Aina Westrheim Ravna, Ingebrigt Sylte, Trine Grønhaug Halvorsen, G. Hege Thoresen, Trond Vidar Hansen · 2015 · European Journal of Medicinal Chemistry
- Antidiabetic effect of SN158 through PPARα/γ dual activation in ob/ob miceYujung Jung, Yongkai Cao, Suresh Paudel, Goo Yoon, Seung Hoon Cheon, Gyu‐Un Bae, Li Tai Jin, Yong Kee Kim, Su‐Nam Kim · 2017 · Chemico-Biological Interactions
- The Versatile Role of Peroxisome Proliferator-Activated Receptors in Immune-Mediated Intestinal DiseasesEdit Posta, István Fekete, István Zsolt Várkonyi, Éva Zöld, Zsolt Barta · 2024 · Cells
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- Proliferation and differentiation of adipose tissue in prolonged lean and obese critically ill patientsChloë Goossens, Sarah Vander Perre, Greet Van den Berghe, Lies Langouche · 2017 · Intensive Care Medicine Experimental
- Fenofibrate differentially activates PPARα-mediated lipid metabolism in rat kidney and liverVenkat Reddy Pannala, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Elizabeth H. Scholl, Ruchir Shah, Warren Casey, Scott S. Auerbach, Anders Wallqvist · 2025 · Scientific Reports
- Signaling pathways shaping the field of lipidomics.E. P. Ahi, Andrew H. House · 2025 · Prostaglandins & other lipid mediators
- SNPs, transcriptional factor binding sites and diseaseNorman E. Buroker · 2017 · Biomedical Genetics and Genomics
- Clickable corneal neovascularization therapy with ROS-responsive polydopamine silica nanoparticles loaded with fenofibrateKai Fan, Lixue Yu, Yuehuang Wu, Lan Zheng, Xiuqin Yang, Jingwei Lin, Mengyuan Wang, Yingyue Ye, Ruimiao Lin, Quancheng Chen et al. · 2023 · Materials & Design
- Differentially expressed genes in PPARγ-deficient MSCsYun Su, Xiaona Shen, Jie Chen, Carlos M. Isales, Jing Zhao, Xingming Shi · 2017 · Molecular and Cellular Endocrinology
- Integrated approaches to unravel the impact of protein lipoxidation on macromolecular interactionsSilvia Zorrilla, Andreia Mónico, Sofía Duarte, Germán Rivas, Dolores Pérez‐Sala, Marı́a A. Pajares · 2019 · Free Radical Biology and Medicine
- EV-Encapsulated Mitochondrial miRNAs: Enhancing Cardiomyocyte BioenergeticsDhienda C. Shahannaz, Tadahisa Sugiura · 2026 · International Journal of Molecular Sciences
- IL-33 promotes pancreatic β-cell survival and insulin secretion under diabetogenic conditions through PPARγJian Lin, Yan Lan, Daochun Xiang, Rui Ma, Qianjiang Chen, Ke Ding, Jingli Lü · 2023 · European Journal of Pharmacology
- Qing-Luo-Yin Eased Adjuvant-Induced Arthritis by Inhibiting SIRT1-Controlled Visfatin Production in White Adipose TissuesDandan Wang, Meng-Ke Song, Qin Yin, Wen-Gang Chen, Opeyemi Joshua Olatunji, Kui Yang, Jian Zuo · 2024 · Journal of Inflammation Research
- Protective effects of pioglitazone on vascular endothelial cell dysfunction induced by high glucose via inhibition of IKKα/β–NFκB signaling mediated by PPARγ in vitroChunxiang Chen, Shaorong Peng, Fanghui Chen, Lili Liu, Zhou-Xue Li, Guohua Zeng, Qiren Huang · 2017 · Canadian Journal of Physiology and Pharmacology
- Unlocking secrets: lipid metabolism and lipid droplet crucial roles in SARS-CoV-2 infection and the immune responseVinícius Cardoso Soares, Suelen da Silva Gomes Dias, Julia Cunha Santos, Patrícia Torres Bozza · 2024 · Journal of Leukocyte Biology
- Imidazole propionate ameliorates lipid metabolism in adipocytes to attenuate high-fat diet-induced obesity via PPAR signaling pathwayCaiyu Lin, Zhou Peng, Juan Du, Xiaoyu Shan, Zhongxiao Zhang, Liling Xu, Shan Huang, Jianfang Gao, Xirong Guo · 2025 · Lipids in Health and Disease
- A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic propertiesAntonio Laghezza, Carmen Cerchia, Massimo Genovese, Roberta Montanari, Davide Capelli, Judith Wackerlig, Stefan Simić, Emanuele Falbo, Lucia Pecora, Rosalba Leuci et al. · 2024 · European Journal of Medicinal Chemistry
- Utilization of Cannabidiol in Post-Organ-Transplant Care幸子 小山, Jumar Etkins, Joshua Jun, Matthew Miller, Gerald C. So, Debora L. Gisch, Michael T. Eadon · 2025 · International Journal of Molecular Sciences
- Perfluorooctanoic acid (PFOA) disrupts cardiac performance of thick-shell mussel by inserting into the binding pocket of proliferator-activated receptor gamma and thereby causing lipid metabolism disordersYingying Yu, Kuankuan Yuan, Difei Tong, Weixia Zhang, Weishang Zhou, Weifeng Li, Wei Ming Shi, Wei‐Dong Yang, Xinguo Zhao, Guangxu Liu · 2025 · Environmental Pollution
- Galangin 3-benzyl-5-methylether derivatives function as an adiponectin synthesis-promoting peroxisome proliferator-activated receptor γ partial agonistHyejin Ko, Hongjun Jang, Seungchan An, In Guk Park, Sungjin Ahn, Junpyo Gong, Seok Young Hwang, Soyeon Oh, Soo Yeon Kwak, Won Jun Choi et al. · 2021 · Bioorganic & Medicinal Chemistry
- Musclin Mitigates the Attachment of HUVECs to THP-1 Monocytes in Hyperlipidemic Conditions through PPARα/HO-1-Mediated Attenuation of InflammationWonjun Cho, Heeseung Oh, Sung Woo Choi, A.M. Abd El‐Aty, Fatma Yeşilyurt, Ji Hoon Jeong, Tae Woo Jung · 2023 · Inflammation
- Microparticles Carrying Peroxisome Proliferator-Activated Receptor Alpha Restore the Reduced Differentiation and Functionality of Bone Marrow-Derived Cells Induced by High-Fat DietLuisa Vergori, Émilie Lauret, Raffaella Soleti, Ramaroson Andriantsitohaina, Maria Carmen Martínez · 2017 · Stem Cells Translational Medicine
- Pparγ1 Facilitates ErbB2-Mammary Adenocarcinoma in MiceXuanmao Jiao, Lifeng Tian, Zhao Zhang, Joanna Balcerek, Andrew V. Kossenkov, Mathew Craig Casimiro, Chenguang Wang, Yichuan Liu, Adam Ertel, Raymond E. Soccio et al. · 2021 · Cancers
- RXR Agonists Enhance Lenalidomide Anti-Myeloma Activity and T Cell Functions while Retaining Glucose-Lowering EffectJian Wu, Xiaobei Wang, Min Zhang, Parker Mathews, Yubin Kang · 2023 · Cells
- PPARγ acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific bindingLifeng Tian, Xuanmao Jiao, Chenguang Wang, Danni Li, Adam Ertel, Joanna Achinger-Kawecka, Sankar Addya, Raymond E. Soccio, Eric R. Chen, Balázs Győrffy et al. · 2025 · Oncogene
- Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty AcidsBokai Zhu, Xiaoyang Zhu, Michael G. Borland, Douglas Ralph, Christopher R. Chiaro, Kristopher W. Krausz, James Mukasa Ntambi, Adam B. Glick, Andrew D. Patterson, Gary H. Perdew et al. · 2024 · Biomolecules
- Effects of eicosapentaneoic acid on innate immune responses in an Atlantic salmon kidney cell line in vitroTor Gjøen, Bente Ruyter, Tone-Kari Knutsdatter Østbye · 2024 · PLoS ONE
- Macakurzin C Derivatives as a Novel Pharmacophore for Pan-Peroxisome Proliferator-Activated Receptor ModulatorHyejin Ko, Seungchan An, Hongjun Jang, Sungjin Ahn, In Guk Park, Seok Young Hwang, Junpyo Gong, Soyeon Oh, Soo Yeon Kwak, Won Jun Choi et al. · 2022 · Biomolecules & Therapeutics
- Application of Machine Learning Methods for the Development of Antidiabetic DrugsJuanjuan Zhao, Pengcheng Xu, Xiujuan Liu, Xiaobo Ji, Minjie Li, Dev Sooranna, Xiaosheng Qu, Wencong Lu, Bing Niu · 2021 · Current Pharmaceutical Design
- Lipids and Their Role in Aging and Neurodegenerative DeclineJ. Bora, Smita Lata, Sagar Mondal, Swati Priya, Dinusha Thazhathu Veettil, Sumira Malik, Perinthottathil Sreejith · 2026 · Lipidology
- Identification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesityYi‐Cheng Chang, Meng-Lun Hsieh, Hsiao-Lin Lee, Siow‐Wey Hee, Chi‐Fon Chang, Hsin‐Yung Yen, Yi-An Chen, Yet‐Ran Chen, Ya-Wen Chou, Fu‐An Li et al. · 2025 · EMBO Molecular Medicine
- Hepatocytes functionally reprogrammed by KIAA1199-high colorectal cancer cells favour the accumulation of pro-metastatic Egr1+ neutrophilsLei Li, Lei Zhao, Kui Cao, Peiyi Zhang, Guojie Xu, Jinge Zheng, Zhenyu Lin, Dandan Yu, Jinghua Ren, Jing Zhang et al. · 2026 · Nature Communications
- Thymopentin improves the survival of septic mice by promoting the production of 15‐deoxy‐prostaglandin J2 and activating the PPARγ signaling pathwayYe Zhang, Xue Yang, Wenchao Yan, Rui Li, Qian Ye, Linjun You, Wenhao Xie, Kun Mo, Ruifeng Fu, Yanxiang Wang et al. · 2020 · The FASEB Journal
- Metabolic‐Associated Steatotic Liver Disease: From Molecular Mechanisms to Novel TherapiesJohn Cooper, Parth Patel, Joven Tristeza, Alexander Yang · 2025 · International Journal of Hepatology
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- Metabolic Reprogramming and Immune Metabolism in Sepsis: Targeting the PPAR Pathway for Personalized Therapeutic ApproachesZheqian Wu, Yisheng Chen, Lili Yin, 朱黎明, Fei Ding, Lihua Dai · 2026 · PPAR Research
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- Propane-2-sulfonic acid octadec-9-enyl-amide, a novel PPARα/γ dual agonist, attenuates molecular pathological alterations in learning memory in AD miceYing Li, Yanan Zhang, Qing Wang, Chuang Kuo Wu, Guicheng Du, Ying Zeng, Zhengmao Song, Xing Jiang, Xun Jiang, Rengong Zhuo et al. · 2024 · Neurological Research
- Conservation of the Nuclear Receptor Response Element in HIV-1 LTRs: A Possible PPAR Response Element?Tara Patricia Hurst · 2013 · ISRN Virology
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- Mechanism of Tetrandrine in Ameliorating Hypoxic Pulmonary Hypertension Vascular Remodeling through Transcriptomics and MetabolomicsXiaowei Gong, Feitian Min, Junli Guo, Ziping Zhang, Xin Liu, Wei Guo, Yaguang Wu, Hanzhou Li, Xixing Fang, Yadong Yuan et al. · 2025 · Current Drug Metabolism
- In Silico Integrated Systems Biology Analysis of Gut-Derived Metabolites from Philippine Medicinal Plants Against Atopic DermatitisLegie Mae Soriano, Kumju Youn, Mira Jun · 2025 · International Journal of Molecular Sciences
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- Inflammation, Hormones, and MetabolismMuska Khpal, Mervyn Singer · 2017 · Wiley-VCH eBooks
- Diet and inflammation : the role of nitrate and conjugated linoleic acidCecilia Jädert · 2014 · Figshare
- Caracterização estrutural dos complexos entre os receptores ativadores da proliferação de peroxissomos (PPARs) dos tipos alfa e gama e seus agonistasJademilson C. Santos · 2014 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
- Estudos estruturais e funcionais dos receptores ativadores da proliferação de peroxissomosAmanda Bernardes Muniz · 2013
- THE ROLE OF NITRATE AND CONJUGATED LINOLEIC ACIDCecilia Jädert · 2014
- Tratamento com metformina restaurou danos metabólicos causados pela obesidade, mas induziu a resposta inflamatória hepática.Alexandre Abílio de Souza Teixeira · 2015
- Tratamento com metformina restaurou danos metabólicos causados pela obesidade, mas induziu a resposta inflamatória hepáticaSão Paulo · 2015
- Identifying Changes in Punitive Transcriptional Factor Binding Sites Created by PPARα/δ/γ SNPs Associated with DiseaseNorman E. Buroker · 2017 · Journal of Biosciences and Medicines
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