PPARs and lipid ligands in inflammation and metabolism
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ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTPPARs and Lipid Ligands in Inflammation and MetabolismGregory S. Harmon†, Michael T. Lam‡, and Christopher K. Glass‡*View Author Information† Department of Medicine, Division of Digestive Diseases, University of California—Los Angeles, Los Angeles, California 90095, USA‡ Department of Cellular and Molecular Medicine, University of California—San Diego, La Jolla, California 92093, USAE-mail: [email protected].Cite this: Chem. Rev. 2011, 111, 10, 6321–6340Publication Date (Web):October 12, 2011Publication History Received21 April 2011Published online12 October 2011Published inissue 12 October 2011https://pubs.acs.org/doi/10.1021/cr2001355https://doi.org/10.1021/cr2001355review-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views3232Altmetric-Citations141LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Inflammation,Ligands,Lipids,Peptides and proteins,Receptors Get e-Alerts
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Chemical antagonists bind to the respective PPAR isoform, leading to maintenance of the corepressor complex and prevention of agonist binding.
“Chemical antagonists bind to the respective PPAR isoform, leading to the maintenance of the corepressor complex and to the prevention of agonist binding (Harmon et al., 2011).”
From The Peroxisome Proliferator–Activated Receptor (PPAR)-γ Antagonist 2-Chloro-5-Nitro-N-Phenylbenzamide (GW9662) Triggers Perilipin 2 Expression via PPARδ and Induces Lipogenesis and Triglyceride Accumulation in Human THP-1 Macrophages (2020) · cites this paper as Harmon et al., 2011
Section 4.4 (Coactivators and Corepressors; page unavailable) says corepressors bind in the presence of antagonists, whereas agonist binding displaces them. It does not state that chemical antagonists bind a particular PPAR isoform or prevent agonists from binding, so those parts of the mechanism are unsupported. (LLM, conf=0.84)
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- Authors
- Harmon, G. S., Lam, M. T., & Glass, C. K.
- Affiliations
- University of California, Los Angeles (US)
- University of California San Diego (US)
- Corresponding author
- Glass, Christopher K.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-10-12
- Volume
- 111
- Issue
- 10
- Pages
- 6321-6340
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- PMC
- PMC3437919
- OpenAlex
- W2087788651
- Cited by
- 216
- References
- 282
- Citations by year
- 2026: 23 · 2025: 18 · 2024: 24 · 2023: 18 · 2022: 15 · 2021: 17 · 2020: 12 · 2019: 6 · 2018: 11 · 2017: 19 · 2016: 12 · 2015: 11 · 2014: 9 · 2013: 12 · 2012: 9
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Chemical Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (U54GM069338)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- peroxisome proliferator-activated receptors, lipid ligands, inflammation, metabolism, nuclear receptors, endogenous ligands
- MeSH terms
- Animals, Inflammation, Ligands, Transcription, Genetic, Peroxisome Proliferator-Activated Receptors, Lipid Metabolism
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