Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease

Cites (486)

Items 201–400 of 488

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2. Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis
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3. Biochemical and clinical evidence that aspirin-intolerant asthmatic subjects tolerate the cyclooxygenase 2-selective analgetic drug celecoxib
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4. Leukotriene B4 amplifies NF-κB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression
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5. Inhibition of Atherogenesis in BLT1-Deficient Mice Reveals a Role for LTB4 and BLT1 in Smooth Muscle Cell Recruitment
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6. Leukotriene B 4 Augments Neutrophil Phagocytosis of Klebsiella pneumoniae
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7. Tyrosine Kinase Activity Modulates Catalysis and Translocation of Cellular 5-Lipoxygenase
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9. Extranuclear Lipid Bodies, Elicited by CCR3-mediated Signaling Pathways, Are the Sites of Chemokine-enhanced Leukotriene C4 Production in Eosinophils and Basophils
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10. Increased platelet sensitivity to ADP in mice lacking platelet-type 12-lipoxygenase
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11. Characterization of the human 5-lipoxygenase gene promoter.
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12. Eosinophil granules function extracellularly as receptor-mediated secretory organelles
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13. Role of the 5-Lipoxygenase–activating Protein (FLAP) in Murine Acute Inflammatory Responses
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14. Human 5-lipoxygenase contains an essential iron
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15. CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene–dependent mitogenic responses of mast cells
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16. Functional recognition of a distinct receptor preferential for leukotriene E 4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors
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17. Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B 4 synthetic capacity
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18. Protein Kinase A Inhibits Leukotriene Synthesis by Phosphorylation of 5-Lipoxygenase on Serine 523
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19. Treatment of asthma with antileukotrienes: First line or last resort therapy?
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20. Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: A member of a super family of zinc-metallohydrolases
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21. Selective 5-lipoxygenase inhibition in ulcerative colitis
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22. Leukotriene A4 hydrolase: An epoxide hydrolase with peptidase activity
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23. Arachidonic Acid Promotes Phosphorylation of 5-Lipoxygenase at Ser-271 by MAPK-activated Protein Kinase 2 (MK2)
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24. ATP-Dependent Transport of Leukotrienes B4 and C4 by the Multidrug Resistance Protein ABCC4 (MRP4)
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25. Leukotriene B 4 and lipoxin A 4 are regulatory signals for neural stem cell proliferation and differentiation
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26. GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D 4
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27. Cyclic AMP-Mediated Inhibition of 5-Lipoxygenase Translocation and Leukotriene Biosynthesis in Human Neutrophils
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28. Leukotriene A3. A poor substrate but a potent inhibitor of rat and human neutrophil leukotriene A4 hydrolase.
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29. The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury
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30. Leukotriene B4 Is a Physiologically Relevant Endogenous Peroxisome Proliferator-activated Receptor-α Agonist
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31. Molecular Cloning and Functional Expression of a Phorbol Ester-inducible 8S-Lipoxygenase from Mouse Skin
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32. Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits.
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33. Molecular Cloning of the Gene for Human Leukotriene C4 Synthase
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34. Evidence That Arachidonate 15-Lipoxygenase 2 Is a Negative Cell Cycle Regulator in Normal Prostate Epithelial Cells
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35. Leukotriene B4 Receptors BLT1 and BLT2: Expression and Function in Human and Murine Mast Cells
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36. The Identification of a Distinct Export Step following the Biosynthesis of Leukotriene C4 by Human Eosinophils
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37. Egr-1 and Sp1 Interact Functionally with the 5-Lipoxygenase Promoter and Its Naturally Occurring Mutants
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38. Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis
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39. The N-terminal “β-Barrel” Domain of 5-Lipoxygenase Is Essential for Nuclear Membrane Translocation
    Xinsheng Chen, Colin D. Funk · 2001 · Journal of Biological Chemistry
40. Molecular cloning and characterization of another leukotriene B4 receptor
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41. The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity
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42. Enhanced tumor cell adhesion to the subendothelial matrix resulting from 12(S)‐HETE‐induced endothelial cell retraction
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43. The cellular biology of eosinophil eicosanoid formation and function
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44. Ca2+-Signaling Cycle of a Membrane-Docking C2 Domain
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45. Leukotriene A4 hydrolase: A zinc metalloenzyme
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46. 5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins.
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47. Celecoxib in Patients with Asthma and Aspirin Intolerance
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48. Cloning of the cDNA for human 12-lipoxygenase.
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49. Advances in eicosanoid research, novel therapeutic implications
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50. Rapid Import of Cytosolic 5-Lipoxygenase into the Nucleus of Neutrophils after in Vivo Recruitment and in Vitro Adherence
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51. Calcium-dependent Membrane Penetration Is a Hallmark of the C2 Domain of Cytosolic Phospholipase A2 Whereas the C2A Domain of Synaptotagmin Binds Membranes Electrostatically*
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52. Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells.
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53. Molecular Cloning and Characterization of Another Leukotriene B4 Receptor
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54. Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)-indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor
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55. Identification of 15–hydroxy‐5,8,11,13–eicosatetraenoic acid (15–HETE) as a major metabolite of arachidonic acid in human lung
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57. Differential Leukotriene Constrictor Responses in Human Atherosclerotic Coronary Arteries
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58. A Novel Localization of the G-Protein-Coupled CysLT1 Receptor in the Nucleus of Colorectal Adenocarcinoma Cells
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59. Leukotriene B4 Induces In Vitro Fibroblast Chemotaxis
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60. 5-Lipoxygenase Deficiency Reduces Hepatic Inflammation and Tumor Necrosis Factor α–Induced Hepatocyte Damage in Hyperlipidemia-Prone Apoe-Null Mice
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61. IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase and up-regulation of 15-lipoxygenase 1 expression
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62. IL-5 Increases Expression of 5-Lipoxygenase-Activating Protein and Translocates 5-Lipoxygenase to the Nucleus in Human Blood Eosinophils
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63. Targeted Disruption of Leukotriene B4 Receptors BLT1 and BLT2: A Critical Role for BLT1 in Collagen-Induced Arthritis in Mice
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64. Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophilderived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus
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85. The lipoxygenase metabolite 12(S)‐hete induces a cytoskeleton‐dependent increase in surface expression of integrin αiibβ3 on melanoma cells
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