Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease
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ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTLipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in DiseaseJesper Z. Haeggström*† and Colin D. Funk‡View Author Information† Department of Medical Biochemistry and Biophysics, Division of Chemistry 2, Karolinska Institutet, S-171 77 Stockholm, Sweden‡ Department of Biomedical and Molecular Sciences, Queen's University Kingston, ON K7L 3N6, CanadaPhone: +46-8-52487612. Fax: +46-8-7360439. E-mail: [email protected]Cite this: Chem. Rev. 2011, 111, 10, 5866–5898Publication Date (Web):September 22, 2011Publication History Received3 July 2011Published online22 September 2011Published inissue 12 October 2011https://pubs.acs.org/doi/10.1021/cr200246dhttps://doi.org/10.1021/cr200246dreview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views8440Altmetric-Citations636LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cells,Inflammation,Peptides and proteins,Receptors,Rodent models Get e-Alerts
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A candidate family of enzymes with this property is the lipoxygenase family, which catalyzes dioxygenation of polyunsaturated fatty acids in lipids.
“A candidate family of enzymes with this property is the family of lipoxygenases that catalyze the dioxygenation of polyunsaturated fatty acids in lipids [86].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [86]
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- Authors
- Haeggström, J. Z., & Funk, C. D.
- Affiliations
- Karolinska Institutet (SE)
- Queen's University (CA)
- Corresponding author
- Haeggström, Jesper Z.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-09-22
- Volume
- 111
- Issue
- 10
- Pages
- 5866-5898
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2316741846
- Cited by
- 875
- References
- 486
- Citations by year
- 2026: 52 · 2025: 57 · 2024: 70 · 2023: 61 · 2022: 69 · 2021: 69 · 2020: 68 · 2019: 56 · 2018: 57 · 2017: 52 · 2016: 68 · 2015: 50 · 2014: 60 · 2013: 60 · 2012: 23
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- other-oa
- Locations
- Chemical Reviews (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- lipoxygenase, leukotrienes, eicosanoids, arachidonic acid metabolism, inflammation, leukotriene receptors, leukotriene biosynthesis, pathogenesis, leukotriene B4, leukotriene C4, leukotriene D4, leukotriene E4
- MeSH terms
- Humans, Leukotrienes, Lipoxygenases
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