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Functions, Therapeutic Applications, and Synthesis of Retinoids and Carotenoids
Abstract
ADVERTISEMENT RETURN TO ISSUEReviewNEXTFunctions, Therapeutic Applications, and Synthesis of Retinoids and CarotenoidsRosana Álvarez†, Belén Vaz†, Hinrich Gronemeyer‡, and Ángel R. de Lera*†View Author Information† Departamento de Química Orgánica, Centro de Investigación Biomédica (CINBIO), and Instituto de Investigación Biomédica de Vigo (IBIV), Universidade de Vigo, 36310 Vigo, Spain‡ Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)/CNRS/INSERM/ULP, BP 10142, 67404 Illkirch Cedex, C. U. de Strasbourg, France*E-mail: [email protected]Cite this: Chem. Rev. 2014, 114, 1, 1–125Publication Date (Web):November 22, 2013Publication History Received26 February 2013Published online22 November 2013Published inissue 8 January 2014https://pubs.acs.org/doi/10.1021/cr400126uhttps://doi.org/10.1021/cr400126ureview-articleACS PublicationsCopyright © 2013 American Chemical SocietyRequest reuse permissionsArticle Views8977Altmetric-Citations186LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Condensation,Hydrocarbons,Mixtures,Molecular structure,Organic compounds Get e-Alerts
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“Treatment with vitamin A in these cases is not straight-forward, as there is a fear of accumulation of excessive amounts of toxic retinoids that are formed as byproducts of vitamin A pathways.”
From The Role of Vitamin A in Retinal Diseases (2022) · cites this paper as [9]
In the citing paper
“A good example of this toxicity is ABCA4-retinopathy where toxic products of vitamin A accumulate excessively in the retina [9,23,76,77,78].”
From The Role of Vitamin A in Retinal Diseases (2022) · cites this paper as [9]
In the citing paper
“Although abundant lipofuscin accumulation is involved in the aetiology of certain retinal diseases (e.g., AMD, Best disease and ABCA4-retinopathy), it accumulates at a lower level also with age in the RPE of healthy eyes [9,72,73,74,75].”
From The Role of Vitamin A in Retinal Diseases (2022) · cites this paper as [9]
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Metadata
- Authors
- Álvarez, R., Vaz, B., Gronemeyer, H., & de Lera, Á. R.
- Affiliations
- Universidade de Vigo (ES)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- de Lera, Ángel R.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-11-22
- Volume
- 114
- Issue
- 1
- Pages
- 1-125
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2008245372
- Cited by
- 260
- References
- 901
- Citations by year
- 2026: 17 · 2025: 19 · 2024: 21 · 2023: 18 · 2022: 28 · 2021: 14 · 2020: 27 · 2019: 24 · 2018: 20 · 2017: 18 · 2016: 27 · 2015: 15 · 2014: 12
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Reviews (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
- Keywords
- retinoids, carotenoids, retinoid synthesis, carotenoid biosynthesis, vitamin A
- MeSH terms
- Alzheimer Disease, Animals, Antioxidants, Carotenoids, Humans, Metabolic Diseases, Neoplasms, Retinoids, Tretinoin, Vitamin A, Apoptosis, Reactive Oxygen Species, Receptors, Cytoplasmic and Nuclear, beta Carotene
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