The DOI matches its Crossref record; 207 of the 207 references it cites were found in a registry or an index.
Discovery, Synthesis, and Structure–Activity Relationships of Conotoxins
Open accessAbstract
Peptide therapeutics are acclaimed as a promising addition to the pharmaceutical arena, and they continue to attract interest due to their high potency, bioavailability, and fewer concerns with toxicity, drug to drug cross-reactions, and tissue accumulation. Around 700 species of marine snails of the genus Conus are distributed throughout tropical and subtropical waters. As different species preferentially hunt fish, worms, or molluscs they are categorized as piscivorous, vermivorous, or molluscivorous, respectively, although some cone snail species can feed on more than one prey type. These slow-moving creatures evolved into predators through incorporation of a specialized envenomation apparatus that enables them to quickly subdue their fast-moving prey. Conotoxins target a wide range of receptors and ion channels with unparalleled potency and selectivity. They have consequently become the subject of intense research in light of their immense diagnostic and therapeutic potential and are the focus of this review.
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Items 201–207 of 207
Two Toxins from Conus striatus That Individually Induce Tetanic Paralysis
Kelley, W. P., Schulz, J. R., Jakubowski, J. A., Gilly, W. F., & Sweedler, J. V. (2006) · Biochemistry · doi:10.1021/bi061485s · Cited by 26
Recent Progress Towards Pharmaceutical Applications of Disulfide-Rich Cyclic Peptides
Schroeder, C. I., Swedberg, J. E., & Craik, D. J. (2013) · Current Protein and Peptide Science · doi:10.2174/13892037113149990069 · Cited by 25
Self-citationMuttenthaler, M., García‐Ramos, Y., Feytens, D., de Araujo, A. D., & Alewood, P. F. (2010) · Biopolymers · doi:10.1002/bip.21502 · Cited by 19
Self-citationBuczek, P., Buczek, O., & Bułaj, G. (2005) · Biopolymers · doi:10.1002/bip.20211 · Cited by 19
Hui, K., McIntyre, D. D., & French, R. J. (2003) · The Journal of General Physiology · doi:10.1085/jgp.200308842 · Cited by 18
Huang, F., & Du, W. (2009) · Toxicon · doi:10.1016/j.toxicon.2009.03.033 · Cited by 14
Gowd, K. H., Blais, K. D., Elmslie, K. S., Steiner, A. M., Olivera, B. M., & Bulaj, G. W. (2012) · Biopolymers · doi:10.1002/bip.22047 · Cited by 10
Cited by
Chemistry and Enzymology of Disulfide Cross-Linking in Proteins
Fass, D., & Thorpe, C. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00123 · Cited by 321
Metadata
- Authors
- Akondi, K. B., Muttenthaler, M., Dutertre, S., Kaas, Q., Craik, D. J., Lewis, R. J., & Alewood, P. F.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-04-10
- Volume
- 114
- Issue
- 11
- Pages
- 5815-5847
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2052956415
- Cited by
- 323
- References
- 207
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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