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Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases

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Uversky, Vladimir N., Davé, Vrushank, Iakoucheva, Lilia M., Malaney, Prerna, Metallo, Steven J., Pathak, Ravi Ramesh, Joerger, Andreas C.·2014·Chemical Reviews

DOI 10.1021/cr400713rPMC PMC4100540

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ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTPathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human DiseasesVladimir N. Uversky*†‡§, Vrushank Davé∥⊥, Lilia M. Iakoucheva#, Prerna Malaney∥, Steven J. Metallo▽, Ravi Ramesh Pathak∥, and Andreas C. Joerger*▲View Author Information∥ †Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute and ∥Department of Pathology and Cell Biology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States‡ Institute for Biological Instrumentation, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia§ Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 22254, Saudi Arabia⊥ Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, United States# Department of Psychiatry, University of California San Diego, La Jolla, California 92093, United States▽ Department of Chemistry, Georgetown University, Washington, District of Columbia 20057, United States▲ Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, United Kingdom*Phone 1-813-974-5816; fax 1-813-974-7357; e-mail [email protected]*Phone +44-1223-267290; e-mail [email protected]Cite this: Chem. Rev. 2014, 114, 13, 6844–6879Publication Date (Web):May 15, 2014Publication History Received15 December 2013Published online15 May 2014Published inissue 9 July 2014https://pubs.acs.org/doi/10.1021/cr400713rhttps://doi.org/10.1021/cr400713rreview-articleACS PublicationsCopyright © 2014 American Chemical SocietyRequest reuse permissionsArticle Views3882Altmetric-Citations215LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cancer,Diseases and disorders,Genetics,Peptides and proteins,Post-translational modification Get e-Alerts

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Authors: Uversky, V. N., Davé, V., Iakoucheva, L. M., Malaney, P., Metallo, S. J., Pathak, R. R., & Joerger, A. C.
Affiliations: Russian Academy of Sciences (RU)
Moffitt Cancer Center (US)
University of California San Diego (US)
University of South Florida (US)
Georgetown University (US)
MRC Laboratory of Molecular Biology (GB)
Corresponding author: Uversky, Vladimir N.
Joerger, Andreas C.
ORCID: Uversky, Vladimir N.
Iakoucheva, Lilia M.
Malaney, Prerna
Pathak, Ravi Ramesh
Joerger, Andreas C.
Venue: Chemical Reviews
Publisher: American Chemical Society (ACS)
Published: 2014-05-15
Volume: 114
Issue: 13
Pages: 6844-6879
ISSN: 0009-2665 (ISSN-L)
1520-6890
DOI: 10.1021/cr400713r
PMC: PMC4100540
OpenAlex: W2086189298
Cited by: 288
References: 379
Citations by year: 2026: 13 · 2025: 24 · 2024: 16 · 2023: 21 · 2022: 20 · 2021: 13 · 2020: 30 · 2019: 31 · 2018: 26 · 2017: 26 · 2016: 37 · 2015: 24 · 2014: 7
FWCI: 2.98
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Chemical Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
Funders: National Cancer Institute (P50CA119997)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
Keywords: intrinsically disordered proteins, protein misfolding, protein aggregation, human disease, neurodegenerative diseases, protein structure-function relationship
MeSH terms: Disease, Humans, Mutation, Protein Unfolding, Intrinsically Disordered Proteins

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Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases

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