Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases

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Novel VEGFR‐2 Kinase Inhibitors as Anticancer Agents: A Review Focusing on SAR and Molecular Docking Studies (2016–2021)

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Conformational selection in amyloid-based immunotherapy: Survey of crystal structures of antibody-amyloid complexes

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Nature and Consequences of Biological Reductionism for the Immunological Study of Infectious Diseases

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Functions of short lifetime biological structures at large: the case of intrinsically disordered proteins

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Quantitative Binding Behavior of Intrinsically Disordered Proteins to Nanoparticle Surfaces at Individual Residue Level

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The dark proteome of cancer: Intrinsic disorderedness and functionality of HIF-1α along with its interacting proteins

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pH-Responsive Mechanistic Switch Regulates the Formation of Dendritic and Fibrillar Nanostructures of a Functional Amyloid

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Conditional Chaperone–Client Interactions Revealed by Genetically Encoded Photo-cross-linkers

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Cancer-Associated Mutations Perturb the Disordered Ensemble and Interactions of the Intrinsically Disordered p53 Transactivation Domain

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Troponins, intrinsic disorder, and cardiomyopathy

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The Structural and Functional Diversity of Intrinsically Disordered Regions in Transmembrane Proteins

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Intrinsically disordered proteins and phenotypic switching: Implications in cancer

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Probing Surfaces in Dynamic Protein Interactions

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Dissecting physical structure of calreticulin, an intrinsically disordered Ca2+-buffering chaperone from endoplasmic reticulum

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Revisiting the earliest signatures of amyloidogenesis: Roadmaps emerging from computational modeling and experiment

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Co-Evolution of Intrinsically Disordered Proteins with Folded Partners Witnessed by Evolutionary Couplings

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A Unifying Theory

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Anatomy of protein disorder, flexibility and disease-related mutations

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Drug and dye binding induced folding of the intrinsically disordered antimicrobial peptide CM15

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Kinetic Selection and Relaxation of the Intrinsically Disordered Region of a Protein upon Binding

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The complexity of protein interactions unravelled from structural disorder

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Targeting disorders in unstructured and structured proteins in various diseases

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Intrinsic Disorder in BAP1 and Its Association with Uveal Melanoma

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Intrinsic α helix propensities compact hydrodynamic radii in intrinsically disordered proteins

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Genetic Fusion of Thermoresponsive Polypeptides with UCST‐type Behavior Mediates 1D Assembly of Coiled‐Coil Bundlemers

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13C APSY-NMR for sequential assignment of intrinsically disordered proteins

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Identification of Intrinsically Disordered Proteins and Regions by Length-Dependent Predictors Based on Conditional Random Fields

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Identification of intrinsically disordered regions in PTEN and delineation of its function via a network approach

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Structural study of the intrinsically disordered tardigrade damage suppressor protein (Dsup) and its complex with DNA

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Intrinsically disordered proteins (IDPs) studied by EPR and in-cell EPR

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PTEN Inhibition Facilitates Diabetic Corneal Epithelial Regeneration by Reactivating Akt Signaling Pathway

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Power of Pure Shift HαCα Correlations: A Way to Characterize Biomolecules under Physiological Conditions

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Intrinsic disorder may drive the interaction of PROS1 and MERTK in uveal melanoma

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Conditional disorder in proteins: functional transitions between order and disorder

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Expanding the Range of Protein Function at the Far End of the Order-Structure Continuum

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Intrinsic disorder and flexibility in proteins: a challenge for structural biology and drug design

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The Emerging Roles of Protein Interactions with O-GlcNAc Cycling Enzymes in Cancer

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Aberrant O‐Glc NA cylation disrupts GNE enzyme activity in GNE myopathy

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Dancing while self-eating: Protein intrinsic disorder in autophagy

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Integrative structural dynamics probing of the conformational heterogeneity in synaptosomal-associated protein 25

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Unreported intrinsic disorder in proteins: Building connections to the literature on IDPs

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Characterization of the Binding of Small Molecules to Intrinsically Disordered Proteins

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Pharmacological targeting of α‐synuclein and TPPP /p25 in Parkinson's disease: challenges and opportunities in a Nutshell

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Glycosylation of serine/threonine-rich intrinsically disordered regions of membrane-associated proteins in streptococci

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The nature of the biological material and the irreproducibility problem in biomedical research

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Abundance and functional roles of intrinsic disorder in the antimicrobial peptides of the NK-lysin family

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Intrinsically disordered caldesmon binds calmodulin via the “buttons on a string” mechanism

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(Intrinsically disordered) splice variants in the proteome: implications for novel drug discovery

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Intrinsic disorder in spondins and some of their interacting partners

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Intrinsic disorder in PRAME and its role in uveal melanoma

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Molecular signaling involving intrinsically disordered proteins in prostate cancer

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Conformational dynamics and multimodal interaction of Paxillin with the focal adhesion targeting domain

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Target-binding behavior of IDPs via pre-structured motifs

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Intrinsic disorder in biomarkers of insulin resistance, hypoadiponectinemia, and endothelial dysfunction among the type 2 diabetic patients

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Adaptive patterns in the p53 protein sequence of the hypoxia- and cancer-tolerant blind mole rat Spalax

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Perspectives on drug discovery strategies based on IDPs

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The Methods and Tools for Intrinsic Disorder Prediction and their Application to Systems Medicine

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Presence and structure‐activity relationship of intrinsically disordered regions across mucins

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IDRMutPred: predicting disease-associated germline nonsynonymous single nucleotide variants (nsSNVs) in intrinsically disordered regions

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Pulsed electric fields induce modulation of protein liquid–liquid phase separation

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Hepatitis C Virus Infection and Intrinsic Disorder in the Signaling Pathways Induced by Toll-Like Receptors

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When an underdog becomes a major player: the role of protein structural disorder in the Atg8 conjugation system

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Stable folding intermediates prevent fast interconversion between the closed and open states of Mad2 through its denatured state

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Decision-Tree Based Meta-Strategy Improved Accuracy of Disorder Prediction and Identified Novel Disordered Residues Inside Binding Motifs

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The PentUnFOLD algorithm as a tool to distinguish the dark and the light sides of the structural instability of proteins

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Characterization of an Extensive Interface on Vitronectin for Binding to Plasminogen Activator Inhibitor-1: Adoption of Structure in an Intrinsically Disordered Region

Puster, L. O., Stanley, C. B., Uversky, V. N., Curtis, J. E., Krueger, S., Chu, Y., & Peterson, C. B. (2019) · Biochemistry · doi:10.1021/acs.biochem.9b00605 · Cited by 10

Preventing Data Ambiguity in Infectious Diseases with Four-Dimensional and Personalized Evaluations

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Identification of a PAI‐1‐binding site within an intrinsically disordered region of vitronectin

Chu, Y., Bucci, J. C., & Peterson, C. B. (2019) · Protein Science · doi:10.1002/pro.3770 · Cited by 10

Intrinsic Disorder in Human Proteins Encoded by Core Duplicon Gene Families

Bibber, N. W. V., Haerle, C., Khalife, R., Dayhoff, G. W., & Uversky, V. N. (2020) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.0c07676 · Cited by 9

Intrinsically disordered BMP4 morphogen and the beak of the finch: Co-option of an ancient axial patterning system

Kulkarni, P., Mohanty, A. R., Salgia, R., & Uversky, V. N. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.203 · Cited by 9

Intrinsic Disorder in the Host Proteins Entrapped in Rabies Virus Particles

Ashraf, H. N., & Uversky, V. N. (2024) · Viruses · doi:10.3390/v16060916 · Cited by 9

Isolation and Characterization of Human Colon Adenocarcinoma Stem-Like Cells Based on the Endogenous Expression of the Stem Markers

Koshkin, S. A., Anatskaya, O. V., Vinogradov, A. E., Uversky, V. N., Dayhoff, G. W., Bystriakova, M. A., Pospelov, V. A., & Tolkunova, E. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094682 · Cited by 9

Transient helicity in intrinsically disordered Axin-1 studied by NMR spectroscopy and molecular dynamics simulations

Bomblies, R., Luitz, M. P., Scanu, S., Madl, T., & Zacharias, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174337 · Cited by 9

Analyzing aggregation propensities of clinically relevant PTEN mutants: a new culprit in pathogenesis of cancer and other PTENopathies

Palumbo, E., Zhao, B., Xue, B., Uversky, V. N., & Davé, V. (2019) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2019.1630005 · Cited by 9

There will always be variants of uncertain significance. Analysis of VUSs

Zhang, H., Kabir, M., Ahmad, S., & Vihinen, M. (2024) · NAR Genomics and Bioinformatics · doi:10.1093/nargab/lqae154 · Cited by 8

Amyloid-β, Tau Protein, α-Synuclein, TDP-43, and FUS in Mixed Pathology: And Intrinsic Disorder to Rule Them All

Siebner, A. S., & Uversky, V. N. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083669 · Cited by 8

Intrinsically Disordered Proteins as Drug Targets

Sánchez-Martínez, M. (2017) · MOJ Proteomics & Bioinformatics · doi:10.15406/mojpb.2017.05.00157 · Cited by 8

The Intrinsically Disordered N Terminus in Atg12 from Yeast Is Necessary for the Functional Structure of the Protein

Popelka, H., Lahiri, V., Hawkins, W. D., Leprevost, F. D. V., Nesvizhskii, A. I., & Klionsky, D. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015036 · Cited by 8

Quantitative Ensemble Interpretation of Membrane Paramagnetic Relaxation Enhancement (mPRE) for Studying Membrane-Associated Intrinsically Disordered Proteins

Jin, H., Liu, D., Ni, Y., Wang, H., & Long, D. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c10847 · Cited by 8

Intrinsically Disordered Proteins Can Behave as Different Polymers across Their Conformational Ensemble

Chakraborty, S., Morozova, T. I., & Barrat, J. (2025) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.4c07020 · Cited by 8

The Anti-Inflammatory Protein TNIP1 Is Intrinsically Disordered with Structural Flexibility Contributed by Its AHD1-UBAN Domain

Shamilov, R., Vinogradova, O., & Aneskievich, B. J. (2020) · Biomolecules · doi:10.3390/biom10111531 · Cited by 9

Theater in the Self-Cleaning Cell: Intrinsically Disordered Proteins or Protein Regions Acting with Membranes in Autophagy

Popelka, H., & Uversky, V. N. (2022) · Membranes · doi:10.3390/membranes12050457 · Cited by 8

What's in the BAGs? Intrinsic disorder angle of the multifunctionality of the members of a family of chaperone regulators

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Conformational and Solvation Dynamics of an Amyloidogenic Intrinsically Disordered Domain of a Melanosomal Protein

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Isotope Reverse-Labeled Infrared Spectroscopy as a Probe of In-Cell Protein Structure

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Disorder in milk proteins: adipophilin and TIP47, important constituents of the milk fat globule membrane

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Intrabody-mediated diverting of HP1β to the cytoplasm induces co-aggregation of H3–H4 histones and lamin-B receptor

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Salt-regulated reversible fibrillation of Mycobacterium tuberculosis isocitrate lyase: Concurrent restoration of structure and activity

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N-terminal truncations of human bHLH transcription factor Twist1 leads to the formation of aggresomes

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The accuracy of force fields on the simulation of intrinsically disordered proteins: A benchmark test on the human p53 tumor suppressor

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