Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases

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121. Cancer-Associated Perturbations in Alternative Pre-messenger RNA Splicing
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122. The evolution of MDM2 family genes
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123. Histone modifications as a pathogenic mechanism of colorectal tumorigenesis
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124. The Arginine-Rich RNA-Binding Motif of HIV-1 Rev Is Intrinsically Disordered and Folds upon RRE Binding
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125. Molecular basis of S100 proteins interacting with the p53 homologs p63 and p73
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126. PTEN inhibits BMI1 function independently of its phosphatase activity
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127. PNUTS Functions as a Proto-Oncogene by Sequestering PTEN
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128. The PTEN Long N-tail is intrinsically disordered: increased viability for PTEN therapy
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129. Inhibition of Vascular Smooth-Muscle Cell Proliferation and Arterial Restenosis by HO-3867, a Novel Synthetic Curcuminoid, through Up-Regulation of PTEN Expression
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130. The Effect of a ΔK280 Mutation on the Unfolded State of a Microtubule-Binding Repeat in Tau
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131. Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy
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132. Post-Translational Modifications of PTEN and their Potential Therapeutic Implications
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133. Structural Comparison of the Unstable drkN SH3 Domain and a Stable Mutant,
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134. PTEN Phosphorylation and Nuclear Export Mediate Free Fatty Acid-Induced Oxidative Stress
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135. Analysis of the oligomeric state and transactivation potential of TAp73α
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136. Altered Histone Modifications in Cancer
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137. Interaction between the Transactivation Domain of p53 and PC4 Exemplifies Acidic Activation Domains as Single-stranded DNA Mimics
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138. HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells
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139. Malleable ribonucleoprotein machine: protein intrinsic disorder in the Saccharomyces cerevisiae spliceosome
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140. Nonspecificity of Binding of γ-Secretase Modulators to the Amyloid Precursor Protein
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141. Domain–domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy
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142. Discovery of Nonpeptidic Small-Molecule AP-1 Inhibitors: Lead Hopping Based on a Three-Dimensional Pharmacophore Model
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143. Molecular basis of the interactions between the p73 N terminus and p300: Effects on transactivation and modulation by phosphorylation
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144. A Single Destabilizing Mutation (F9S) Promotes Concerted Unfolding of an Entire Globular Domain in γS-Crystallin
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145. Enzyme Inhibition by Allosteric Capture of an Inactive Conformation
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146. Identification of a drug target motif: An anti-tumor drug NK109 interacts with a PNxxxxP
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147. Identification of Cytotoxic Drugs That Selectively Target Tumor Cells with MYC Overexpression
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148. Structure and Kinetic Stability of the p63 Tetramerization Domain
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149. Nongenomic Mechanisms of PTEN Regulation
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150. Substrate Sequence Influences γ-Secretase Modulator Activity, Role of the Transmembrane Domain of the Amyloid Precursor Protein
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151. Extensive Alternative Splicing of the Repressor Element Silencing Transcription Factor Linked to Cancer
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152. Adaptive Evolution of p53 Thermodynamic Stability
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153. Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish
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154. Small Molecule Screening Identifies Regulators of the Transcription Factor ΔFosB
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155. DNA Binding Restricts the Intrinsic Conformational Flexibility of Methyl CpG Binding Protein 2 (MeCP2)
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156. Alternative Splicing Programs in Prostate Cancer
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157. TRIMming p53 for ubiquitination
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158. Post-translational modifications of lysine in DNA-damage repair
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159. Role of TFG sequences outside the coiled-coil domain in TRK-T3 oncogenic activation
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160. The Amyloid Precursor Protein C-Terminal Fragment C100 Occurs in Monomeric and Dimeric Stable Conformations and Binds γ-Secretase Modulators
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161. Beyond the genome and proteome: targeting protein modifications in cancer
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162. The electrostatic surface of MDM2 modulates the specificity of its interaction with phosphorylated and unphosphorylated p53 peptides
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163. The Regulatory Domain Stabilizes the p53 Tetramer by Intersubunit Contacts with the DNA Binding Domain
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164. The Solution Structure of a Chimeric LEKTI Domain Reveals a Chameleon Sequence
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165. Camptothecin binds to a synthetic peptide identified by a T7 phage display screen
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166. Structural basis of p63α SAM domain mutants involved in AEC syndrome
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167. NSAID-Based γ-Secretase Modulators Do Not Bind to the Amyloid-β Polypeptide
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168. Identification of trimannoside-recognizing peptide sequences from a T7 phage display screen using a QCM device
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169. Screening of Paclitaxel-Binding Molecules from a Library of Random Peptides Displayed on T7 Phage Particles Using Paclitaxel-Photoimmobilized Resin
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170. P6981, An Arylstibonic Acid, Is a Novel Low Nanomolar Inhibitor of cAMP Response Element-Binding Protein Binding to DNA
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171. New insights into PTEN regulation mechanisms and its potential function in targeted therapies
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172. 12 Arylstibonic acids that inhibit the DNA binding of five B-ZIP dimers
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173. Association between the p53 codon 72 Arg/Pro polymorphism and hepatocellular carcinoma risk
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174. Inhibition of proteolysis and other posttranslational modifications with substrate‐targeted inhibitors
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175. The Roche Cancer Genome Database (RCGDB)
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176. Classification of Proteins: Available Structural Space for Molecular Modeling
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177. Abstract 16618: Pharmacological Modulation of PTEN Ameliorates the Progression of Pulmonary Hypertension in Heart Failure
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