Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery

Degradable Thermoresponsive Nanogels for Protein Encapsulation and Controlled Release

Bhuchar, N., Sunasee, R., Ishihara, K., Thundat, T. G., & Narain, R. (2011) · Bioconjugate Chemistry · doi:10.1021/bc2003814 · Cited by 105

Design for optimization of nanoparticles integrating biomaterials for orally dosed insulin

Woitiski, C. B., Veiga, F., Ribeiro, A. J., & Neufeld, R. J. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2009.06.002 · Cited by 104

Design of Hybrid Hydrogels with Self-Assembled Nanogels as Cross-Linkers: Interaction with Proteins and Chaperone-Like Activity

Morimoto, N., Endo, T., Iwasaki, Y., & Akiyoshi, K. (2005) · Biomacromolecules · doi:10.1021/bm050156x · Cited by 104

Tuneable semi-synthetic network alginate for absorptive encapsulation and controlled release of protein therapeutics

Chan, A. W. J., & Neufeld, R. J. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.111 · Cited by 104

Osteoblastic bone formation is induced by using nanogel‐crosslinking hydrogel as novel scaffold for bone growth factor

Hayashi, C., Hasegawa, U., Saita, Y., Hemmi, H., Hayata, T., Nakashima, K., Ezura, Y., Amagasa, T., Akiyoshi, K., & Noda, M. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21760 · Cited by 104

Thermo-sensitivity and triggered drug release of polysaccharide nanogels derived from pullulan-g-poly(l-lactide) copolymers

Seo, S., Lee, C., Jung, Y.-S., & Na, K. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.08.061 · Cited by 104

Innovations in avoiding particle clearance from blood by Kupffer cells: cause for reflection.

Moghimi, S. M., & Davis, S. S. (1994) · PubMed · Cited by 104

A nanogel of on-site tunable pH-response for efficient anticancer drug delivery

Zhou, T., Xiao, C., Fan, J. R., Chen, S., Shen, J., Wu, W., & Zhou, S. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.08.017 · Cited by 103

Chitosan-g-poly(N-isopropylacrylamide) based nanogels for tumor extracellular targeting

Duan, C., Zhang, D., Wang, F., et al. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.02.050 · Cited by 101

Hybrid Nanogels with Physical and Chemical Cross‐Linking Structures as Nanocarriers

Morimoto, N., Endo, T., Ohtomi, M., Iwasaki, Y., & Akiyoshi, K. (2005) · Macromolecular Bioscience · doi:10.1002/mabi.200500051 · Cited by 100

Injectable Hydrogel for Sustained Protein Release by Salt‐Induced Association of Hyaluronic Acid Nanogel

Nakai, T., Hirakura, T., Sakurai, Y., Shimoboji, T., Ishigai, M., & Akiyoshi, K. (2012) · Macromolecular Bioscience · doi:10.1002/mabi.201100352 · Cited by 100

Synthesis, Reductive Cleavage, and Cellular Interaction Studies of Biodegradable, Polyglycerol Nanogels

Steinhilber, D., Sisson, A. L., Mangoldt, D., Welker, P., Licha, K., & Haag, R. (2010) · Advanced Functional Materials · doi:10.1002/adfm.201000410 · Cited by 100

The effect of the controlled release of basic fibroblast growth factor from ionic gelatin-based hydrogels on angiogenesis in a murine critical limb ischemic model

Layman, H., Spiga, M., Brooks, T., Pham, S. M., Webster, K. A., & Andreopoulos, F. M. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.01.044 · Cited by 98

Therapeutic lymphangiogenesis using stem cell and VEGF-C hydrogel

Hwang, J. H., Kim, I. G., Lee, J. Y., Piao, S., Lee, D. S., Lee, T. S., Ra, J. C., & Lee, J. Y. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.02.051 · Cited by 98

Chemotherapeutic evaluation of alginate nanoparticle-encapsulated azole antifungal and antitubercular drugs against murine tuberculosis

Ahmad, Z., Sharma, S., & Khuller, G. K. (2007) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2007.05.001 · Cited by 97

The binding of pullulan modified cholesteryl nanogels to Aβ oligomers and their suppression of cytotoxicity

Boridy, S., Takahashi, H., Akiyoshi, K., & Maysinger, D. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.06.010 · Cited by 97

Self-Organized Nanogels Responding to Tumor Extracellular pH: pH-Dependent Drug Release and in Vitro Cytotoxicity against MCF-7 Cells

Na, K., Lee, E. S., & Bae, Y. H. (2007) · Bioconjugate Chemistry · doi:10.1021/bc070052e · Cited by 95

Biocompatibility of injectable chitosan–phospholipid implant systems

Souza, R. D., Zahedi, P., Allen, C. J., & Piquette‐Miller, M. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.04.003 · Cited by 95

Hydrotropic hyaluronic acid conjugates: Synthesis, characterization, and implications as a carrier of paclitaxel

Saravanakumar, G., Choi, K. Y., Yoon, H. Y., Kim, K., Park, J. H., Kwon, I. C., & Park, K. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.04.041 · Cited by 95

Pharmacokinetics and biodistribution of near-infrared fluorescence polymeric nanoparticles

Yang, Z., Leon, J. W., Martin, M., Harder, J., Zhang, R., Liang, D., Lü, W., Tian, M., Gelovani, J. G., Qiao, A., et al. (2009) · Nanotechnology · doi:10.1088/0957-4484/20/16/165101 · Cited by 94

PEGylation of biodegradable dextran nanogels for siRNA delivery

Naeye, B., Raemdonck, K., Remaut, K., Sproat, B. S., Demeester, J., & Smedt, S. C. D. (2010) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2010.04.010 · Cited by 93

Redox- and oxidant-mediated regulation of interleukin-10: an anti-inflammatory, antioxidant cytokine?

Haddad, J. J., & Fahlman, C. S. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02094-6 · Cited by 93

A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting: In vitro evaluation

Oh, N. M., Oh, K. T., Baik, H. J., Lee, B. R., Lee, A. H., Youn, Y. S., & Lee, E. S. (2010) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2010.02.023 · Cited by 92

Potential of self-organizing nanogel with acetylated chondroitin sulfate as an anti-cancer drug carrier

Park, W., Park, S., & Na, K. (2010) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2010.05.025 · Cited by 91

Characterization of gelatin-sodium alginate complex coacervation system

Nagarsenker, M., & Shinde, U. A. (2009) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.56033 · Cited by 89

Formulations of biodegradable Nanogel carriers with 5′-triphosphates of nucleoside analogs that display a reduced cytotoxicity and enhanced drug activity

Kohli, E., Han, H.-Y., Zeman, A. D., & Vinogradov, S. V. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.04.007 · Cited by 89

Novel folated and non-folated pullulan bioconjugates for anticancer drug delivery

Scomparin, A., Salmaso, S., Bersani, S., Satchi‐Fainaro, R., & Caliceti, P. (2011) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2011.02.012 · Cited by 88

Coupling exo- and endocytosis: An essential role for PIP2 at the synapse

Koch, M., & Holt, M. G. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.02.008 · Cited by 87

An injectable and glucose-sensitive nanogel for controlled insulin release

Wu, Z., Zhang, X., Guo, H., Li, C., & Yu, D. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm34082h · Cited by 87

Docetaxel loaded oleic acid-coated hydroxyapatite nanoparticles enhance the docetaxel-induced apoptosis through activation of caspase-2 in androgen independent prostate cancer cells

Luo, Y., Ling, Y., Guo, W., Pang, J., Liu, W., Fang, Y., Wen, X., Wei, K., & Gao, X. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.07.108 · Cited by 85

pH sensitive Laponite/alginate hybrid hydrogels: swelling behaviour and release mechanism

Li, Y., Maciel, D., Tomás, H., Rodrigues, J., Ma, H., & Shi, X. (2011) · Soft Matter · doi:10.1039/c1sm05345k · Cited by 85

Biocleavable comb-shaped gene carriers from dextran backbones with bioreducible ATRP initiation sites

Wang, Z., Zhu, Y. G., Chai, M. Y., et al. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.11.027 · Cited by 85

Biocompatible and degradable nanogels via oxidation reactions of synthetic thiomers in inverse miniemulsion

Gröll, J., Singh, S., Albrecht, K., & Möller, M. (2009) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.23595 · Cited by 82

In-vivo tumor targeting of pluronic-based nano-carriers

Kim, J., Choi, W. I., Kim, Y., Tae, G., Lee, S. Y., Kim, K., & Kwon, I. C. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.06.010 · Cited by 82

Polymeric nanogel formulations of nucleoside analogs

Vinogradov, S. V. (2006) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.4.1.5 · Cited by 82

Increased bone growth by local prostaglandin E2 in rats

Yang, R., Liu, T., & Lin‐Shiau, S. (1993) · Calcified Tissue International · doi:10.1007/bf00675627 · Cited by 81

pH-controllable release using functionalized mesoporous silica nanoparticles as an oral drug delivery system

Cheng, S., Liao, W., Chen, L., & Lee, C. (2011) · Journal of Materials Chemistry · doi:10.1039/c0jm04490c · Cited by 80

Thermally triggered intracellular explosion of volume transition nanogels for necrotic cell death

Lee, Y., Park, S. Y., Kim, C.-S., & Park, T. G. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.12.008 · Cited by 80

Hyperthermia controlled rapid drug release from thermosensitive magnetic microgels

Regmi, R., Bhattarai, S. R., Sudakar, C., Wani, A. S., Cunningham, R., Vaishnava, P. P., Naik, R., Oupický, D., & Lawes, G. (2010) · Journal of Materials Chemistry · doi:10.1039/c0jm00844c · Cited by 80

Disulfide cross-linked nanospheres from sodium alginate derivative for inflammatory bowel disease: Preparation, characterization, and in vitro drug release behavior

Chang, D., Lei, J., Cui, H., Lü, N., Sun, Y., Zhang, X., Cheng, G., Zheng, H. S., & Yin, Y. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.01.020 · Cited by 77

Thermosensitive nanogels based on dendritic polyglycerol and N-isopropylacrylamide for biomedical applications

Cuggino, J. C., I., C. I. A., Strumia, M. C., Welker, P., Licha, K., Steinhilber, D., Mutihac, R., & Calderón, M. (2011) · Soft Matter · doi:10.1039/c1sm06357j · Cited by 77

Mineralized hyaluronic acid nanoparticles as a robust drug carrier

Han, S.-Y., Han, H. S., Lee, S. C., Kang, Y. M., Kim, I.-S., & Park, J. H. (2011) · Journal of Materials Chemistry · doi:10.1039/c1jm10466g · Cited by 75

“Water dispersible pH-responsive chitosan nanogels modified with biocompatible crosslinking-agents”

Pujana, M. A., Pérez‐Álvarez, L., Iturbe, L. C. C., et al. (2012) · Polymer · doi:10.1016/j.polymer.2012.05.027 · Cited by 75

Synthesis and characterization of thiolated alginate-albumin nanoparticles stabilized by disulfide bonds. Evaluation as drug delivery systems

Martínez, A., Peinado, I. I., Lozano, R., Teijón, J. M., & Blanco, M. D. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.09.038 · Cited by 74

Disulfide Core Cross‐Linked PEGylated Polypeptide Nanogel Prepared by a One‐Step Ring Opening Copolymerization of N‐Carboxyanhydrides for Drug Delivery

Xing, T., Lai, B., Ye, X., & Yan, L. (2011) · Macromolecular Bioscience · doi:10.1002/mabi.201000510 · Cited by 74

Preparation and optimization of surface-treated methotrexate-loaded nanogels intended for brain delivery

Azadi, A., Hamidi, M., Khoshayand, M., Amini, M., & Rouini, M. R. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.05.066 · Cited by 73

Intracellular delivery and anti-cancer effect of self-assembled heparin-Pluronic nanogels with RNase A

Choi, J. H., Jang, J. Y., Joung, Y. K., Kwon, M. H., & Park, K. D. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.07.118 · Cited by 72

Nano‐Encapsulation of Lipase by Self‐Assembled Nanogels: Induction of High Enzyme Activity and Thermal Stabilization

Sawada, S., & Akiyoshi, K. (2010) · Macromolecular Bioscience · doi:10.1002/mabi.200900304 · Cited by 72

Polyglycerol nanogels: highly functional scaffolds for biomedical applications

Sisson, A. L., & Haag, R. (2010) · Soft Matter · doi:10.1039/c0sm00149j · Cited by 72

Dual-stimuli sensitive nanogels fabricated by self-association of thiolated hydroxypropyl cellulose

Tan, J., Kang, H., Liu, R., Wang, D., Jin, X., Li, Q., & Huang, Y. P. (2010) · Polymer Chemistry · doi:10.1039/c0py00348d · Cited by 71

Cancer cell specific targeting of nanogels from acetylated hyaluronic acid with low molecular weight

Park, W., Kim, K. S., Bae, B.-C., Kim, Y.-H., & Na, K. (2010) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2010.04.008 · Cited by 70

The use of low molecular weight heparin–pluronic nanogels to impede liver fibrosis by inhibition the TGF-β/Smad signaling pathway

Lee, J., Lee, H., Joung, Y. K., Jung, K. H., Choi, J.-H., Lee, D., Park, K. D., & Hong, S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.10.023 · Cited by 70

A unique device for controlled electrospinning

Mitchell, S. B., & Sanders, J. E. (2006) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30673 · Cited by 70

Development of Disulfide Core‐Crosslinked Pluronic Nanoparticles as an Effective Anticancer‐Drug‐Delivery System

Al‐Nahain, A., Lee, H., Lee, Y., Lee, K. D., & Park, S. Y. (2011) · Macromolecular Bioscience · doi:10.1002/mabi.201100083 · Cited by 70

Aureobasidium pullulans, an economically important polymorphic yeast with special reference to pullulan

Rajeeva, G., Ranjan, S., Monika, G., & Gaur, M. K. (2010) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb10.948 · Cited by 70

Dual crosslinked hydrogel nanoparticles by nanogel bottom-up method for sustained-release delivery

Shimoda, A., Sawada, S., Kano, A., Maruyama, A., Moquin, A., Winnik, F. M., & Akiyoshi, K. (2011) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2011.09.025 · Cited by 69

The effect of hyaluronic acid size and concentration on branching morphogenesis and tubule differentiation in developing kidney culture systems: Potential applications to engineering of renal tissues

Rosines, E., Schmidt, H. J., & Nigám, S. K. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.07.034 · Cited by 69

Hemocompatibility of siRNA loaded dextran nanogels

Naeye, B., Deschout, H. G., Röding, M., Rudemo, M., Delanghe, J., Devreese, K. M. J., Demeester, J., Braeckmans, K., Smedt, S. C. D., & Raemdonck, K. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.015 · Cited by 69

Control of burst release from nanogels via layer by layer assembly

Tan, J. P. K., Wang, Q., & Tam, K. C. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.03.012 · Cited by 68

Self-assembled nanoparticle drug delivery systems from galactosylated polysaccharide–doxorubicin conjugate loaded doxorubicin

Cao, Y., Gu, Y., Ma, H., Bai, J. Y., Liu, L., Zhao, P., & He, H. (2009) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2009.11.008 · Cited by 67

Roles of Extracellular Chaperones in Amyloidosis

Wyatt, A. R., Yerbury, J. J., Dabbs, R. A., & Wilson, M. R. (2012) · Journal of Molecular Biology · doi:10.1016/j.jmb.2012.01.004 · Cited by 67

Photo-cross-linked mPEG-poly(γ-cinnamyl-l-glutamate) micelles as stable drug carriers

Yan, L., Yang, L., He, H., Hu, X., Xie, Z., Huang, Y., & Jing, X. (2012) · Polymer Chemistry · doi:10.1039/c2py20049j · Cited by 66

A new drug nanocarrier consisting of polyarginine and hyaluronic acid

Oyarzun-Ampuero, F. A., Goycoolea, F. M., Torres, D., & Alonso, M. J. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2011.04.008 · Cited by 66

Self-assembled glycol chitosan nanogels containing palmityl-acylated exendin-4 peptide as a long-acting anti-diabetic inhalation system.

Lee, J., Lee, C., Kim, T. H., Lee, E. S., Shin, B., Chi, S.-C., Park, E., Lee, K.-C., & Youn, Y. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.05.029 · Cited by 65

Polysaccharide nanogel gene delivery system with endosome-escaping function: Co-delivery of plasmid DNA and phospholipase A2

Toita, S., Sawada, S., & Akiyoshi, K. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.12.008 · Cited by 65

Protein Release from Biodegradable Dextran Nanogels

Thienen, T. G. V., Raemdonck, K., Demeester, J., & Smedt, S. C. D. (2007) · Langmuir · doi:10.1021/la700736v · Cited by 65

Disulfide-crosslinked heparin-pluronic nanogels as a redox-sensitive nanocarrier for intracellular protein delivery

Nguyen, D. H., Choi, J. H., Joung, Y. K., & Park, K. D. (2011) · Journal of Bioactive and Compatible Polymers · doi:10.1177/0883911511406031 · Cited by 65

Enzymatically degradable nanogels by inverse miniemulsion copolymerization of acrylamide with dextran methacrylates as crosslinkers

Klinger, D., Aschenbrenner, E. M., Weiss, C. K., & Landfester, K. (2011) · Polymer Chemistry · doi:10.1039/c1py00415h · Cited by 64

Cell Response to the Exposure to Chitosan–TPP//Alginate Nanogels

Schütz, C. A., Juillerat‐Jeanneret, L., Käuper, P., & Wandrey, C. (2011) · Biomacromolecules · doi:10.1021/bm201231x · Cited by 64

Effects of cholesterol‐bearing pullulan (CHP)‐nanogels in combination with prostaglandin E1 on wound healing

Kobayashi, H., 片倉, 修., Morimoto, N., et al. (2009) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.31373 · Cited by 60

Nanogel‐based delivery system enhances PGE2 effects on bone formation

Kato, N., Hasegawa, U., Morimoto, N., Saita, Y., Nakashima, K., Ezura, Y., Kurosawa, H., Akiyoshi, K., & Noda, M. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21160 · Cited by 60

Ultrasound-triggered thrombolysis using urokinase-loaded nanogels

Jin, H., Tan, H., Zhao, L., Sun, W., Zhu, L., Sun, Y., Hao, H.-J., Haiying, X., Liu, L., Qu, X., et al. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.06.001 · Cited by 59

Biodegradation, biocompatibility, and drug delivery in poly(ω-pentadecalactone-co-p-dioxanone) copolyesters

Liu, J., Jiang, Z., Zhang, S., Liu, C., Gross, R. A., Kyriakides, T. R., & Saltzman, W. M. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.046 · Cited by 59

Functional Cycloamylose as a Polysaccharide-Based Biomaterial: Application in a Gene Delivery System

Toita, S., Morimoto, N., & Akiyoshi, K. (2009) · Biomacromolecules · doi:10.1021/bm901109z · Cited by 59

Peptide-based delivery to bone

Aoki, K., Alles, N., Soysa, N. S., & Ohya, K. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.05.017 · Cited by 59

Tamoxifen‐loaded thiolated alginate‐albumin nanoparticles as antitumoral drug delivery systems

Martínez, A., Benito, M., Peinado, I. I., Teijón, J. M., & Blanco, M. D. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34051 · Cited by 57

Polysaccharide nanogel delivery of a TNF-α and RANKL antagonist peptide allows systemic prevention of bone loss

Alles, N., Soysa, N. S., Hussain, M. A., Tomomatsu, N., Saito, H., Baron, R., Morimoto, N., Aoki, K., Akiyoshi, K., & Ohya, K. (2009) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2009.01.002 · Cited by 56

PEG-Assisted DNA Solubilization in Organic Solvents for Preparing Cytosol Specifically Degradable PEG/DNA Nanogels

Mok, H., & Park, T. G. (2006) · Bioconjugate Chemistry · doi:10.1021/bc060119i · Cited by 56

Glutathione Reductase and a Mitochondrial Thioredoxin Play Overlapping Roles in Maintaining Iron-Sulfur Enzymes in Fission Yeast

Song, J.-Y., Cha, J., Lee, J., & Roe, J.-H. (2006) · Eukaryotic Cell · doi:10.1128/ec.00244-06 · Cited by 55

Nanogel‐based scaffold delivery of prostaglandin E2 receptor–specific agonist in combination with a low dose of growth factor heals critical‐size bone defects in mice

Kamolratanakul, P., Hayata, T., Ezura, Y., Kawamata, A., Hayashi, C., Yamamoto, Y., Hemmi, H., Nagao, M., Hanyu, R., Notomi, T., et al. (2010) · Arthritis & Rheumatism · doi:10.1002/art.30151 · Cited by 54

Cell Specific Peptide‐Conjugated Polysaccharide Nanogels for Protein Delivery

Shimoda, A., Sawada, S., & Akiyoshi, K. (2011) · Macromolecular Bioscience · doi:10.1002/mabi.201000491 · Cited by 53

Effect of Size on the Biodistribution and Blood Clearance of Etoposide-Loaded PLGA Nanoparticles.

Yadav, K. S., Chuttani, K., Mishra, A. K., & Sawant, K. K. (2016) · PubMed · Cited by 53

Synthesis of Biodegradable Hydrogel Nanoparticles for Bioapplications Using Inverse Miniemulsion RAFT Polymerization

de Oliveira, M. A. M., Boyer, C. A., Nele, M., Pinto, J. C., Zetterlund, P. B., & Davis, T. P. (2011) · Macromolecules · doi:10.1021/ma201531w · Cited by 52

Hydrogel nanoparticle formed by self-assembly of hydrophobized polysaccharide. Stabilization of adriamycin by complexation

Akiyoshi, K., Taniguchi, I., Fukui, H., & Sunamoto, J. (1996) · European Journal of Pharmaceutics and Biopharmaceutics · Cited by 51

Interactions of glycyrrhizin with organic anion transporting polypeptides of rat and human liver

Ismair, M. G. (2003) · Hepatology Research · doi:10.1016/s1386-6346(03)00154-2 · Cited by 51

Self-quenchable biofunctional nanoparticles of heparin–folate-photosensitizer conjugates for photodynamic therapy

Li, L., Bae, B.-C., Tran, T. H., Yoon, K., Na, K., & Huh, K. M. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.05.011 · Cited by 50

Preparation and characterization of tri-block poly(lactide)–poly(ethylene glycol)–poly(lactide) nanogels for controlled release of naltrexone

Asadi, H., Rostamizadeh, K., Salari, D., & Hamidi, M. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.06.035 · Cited by 50

One pot, single phase synthesis of thermo-sensitive nano-carriers by photo-crosslinking of a diacrylated pluronic

Choi, W. I., Tae, G., & Kim, Y. (2008) · Journal of Materials Chemistry · doi:10.1039/b801262h · Cited by 48

Preparation and evaluation of carboplatin biodegradable polymeric nanoparticles

Nanjwade, B. K., Singh, J., Parikh, K. A., & Manvi, F. V. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.10.030 · Cited by 45

Targeting ligand-functionalized and redox-sensitive heparin-Pluronic nanogels for intracellular protein delivery

Nguyen, D. H., Joung, Y. K., Choi, J. H., Moon, H. T., & Park, K. D. (2011) · Biomedical Materials · doi:10.1088/1748-6041/6/5/055004 · Cited by 44

Drug-loaded chondroitin sulfate-based nanogels: Preparation and characterization

Xi, J., Zhou, L., & Dai, H. (2012) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2012.05.007 · Cited by 44

Release profile and stability evaluation of optimized chitosan/alginate nanoparticles as EGFR antisense vector

Gazori, T. (2010) · International Journal of Nanomedicine · doi:10.2147/ijn.s9551 · Cited by 42

Cyclodextrin/dextran based drug carriers for a controlled release of hydrophobic drugs in zebrafish embryos

Peng, K., Cui, C., Tomatsu, I., Porta, F., Meijer, A. H., Spaink, H. P., & Kros, A. (2010) · Soft Matter · doi:10.1039/c0sm00096e · Cited by 41

Targeted Delivery of Paclitaxel to Tumor Cells: Synthesis and in Vitro Evaluation

Ndungu, J. M., Lu, Y., Zhu, S., Yang, C., Wang, X., Chen, G. Z., Shin, D. M., Snyder, J. P., Shoji, M., & Sun, A. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm901763f · Cited by 37

Preparation of complex nano-particles based on alginic acid/poly[(2-dimethylamino) ethyl methacrylate] and a drug vehicle for doxorubicin release controlled by ionic strength

Cai, H. X., Ni, C., & Zhang, L. (2011) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2011.10.020 · Cited by 37

Chondrogenesis of synovium-derived mesenchymal stem cells in gene-transferred co-culture system

Varshney, R., Zhou, R., Hao, J., Yeo, S. S., Chooi, W. H., Fan, J., & Wang, D. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.038 · Cited by 37

Biological activity of heterologous murine interleukin-10 and preliminary studies on the use of a dextrin nanogel as a delivery system

Carvalho, V., Castanheira, P., Faria, T. Q., Gonçalves, C., Madureira, P., Faro, C., Domingues, L., Brito, R. M. M., Vilanova, M., & Gama, M. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.08.040 · Cited by 33

Properties of xyloglucan hydrogel as the biomedical sustained-release carriers

Chen, D., Guo, P., Chen, S., et al. (2012) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-012-4564-z · Cited by 32

Heparin Activates PKR by Inducing Dimerization

Anderson, E., Pierre-Louis, W., Wong, C. J., Lary, J. W., & Cole, J. L. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.09.025 · Cited by 31

Chitosan/TPP-Hyaluronic Acid Nanoparticles: A New Vehicle for Gene Delivery to the Spinal Cord

Gwak, S., Jung, J. K., An, S. S., Kim, H. J., Oh, J. S., Pennant, W. A., Lee, H. Y., Kong, M. H., Kim, K. N., Yoon, D. H., et al. (2012) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/092050611x584090 · Cited by 31

Inhibition of EGFR expression with chitosan/alginate nanoparticles encapsulating antisense oligonucleotides in T47D cell line using RT-PCR and immunocytochemistry

Gazori, T., Haririan, I., Fouladdel, S., et al. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.01.022 · Cited by 27

Enhanced preclinical efficacy of tamoxifen developed as alginate–cysteine/disulfide bond reduced albumin nanoparticles

Martínez, A., Muniz, E. C., Peinado, I. I., Teijón, J. M., & Blanco, M. D. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.07.045 · Cited by 26

The enhanced antitumor effects of biodegradable cationic heparin-polyethyleneimine nanogels delivering HSulf-1 gene combined with cisplatin on ovarian cancer

LIU, P., Gou, M., Yi, T., Qi, X., Xie, C., Zhou, S., Deng, H., Wei, Y., & Zhao, X. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1558 · Cited by 25

The use of cationic nanogels to deliver proteins to myeloma cells and primary T lymphocytes that poorly express heparan sulfate

Watanabe, K., Tsuchiya, Y. N., Kawaguchi, Y., Sawada, S., Ayame, H., Akiyoshi, K., & Tsubata, T. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.058 · Cited by 25

Self‐assembled dextrin nanogel as protein carrier: Controlled release and biological activity of IL‐10

Carvalho, V., Castanheira, P., Madureira, P., Ferreira, S. A., Costa, C., Teixeira, J. P., Faro, C., Vilanova, M., & Gama, M. (2011) · Biotechnology and Bioengineering · doi:10.1002/bit.23125 · Cited by 25

Delivery of Nucleic Acids

Mastrobattista, E., Hennink, W. E., & Schiffelers, R. M. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9349-6 · Cited by 24

In vitro characterization, and in vivo studies of crosslinked lactosaminated carboxymethyl chitosan nanoparticles

Zheng, H. S., Zhang, X., Yin, Y., Xiong, F., Gong, X., Zhu, Z., Lü, B., & Xu, P. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.12.067 · Cited by 22

Template-free synthesis of biodegradable nanogels with tunable sizes as potential carriers for drug delivery

Wu, J., Liu, X., Wang, Y., & Wang, J. (2009) · Journal of Materials Chemistry · doi:10.1039/b908768k · Cited by 22

Evaluation of the ability of adjuvant tamoxifen‐benefit gene signatures to predict outcome of hormone‐naive estrogen receptor‐positive breast cancer patients treated with tamoxifen in the advanced setting

Sieuwerts, A. M., Lyng, M., Gelder, M. E. M., de Weerd, V., Sweep, F. C. G. J., Foekens, J. A., Span, P. N., Martens, J. W. M., & Ditzel, H. J. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.07.003 · Cited by 19

Efficient inhibition of ovarian cancer by recombinant CXC chemokine ligand 10 delivered by novel biodegradable cationic heparin-polyethyleneimine nanogels

Yang, F., GOU, M., Deng, H., Yi, T., Zhong, Q., Wei, Y., & Zhao, X. (2012) · Oncology Reports · doi:10.3892/or.2012.1853 · Cited by 17

The tumor necrosis factor type 2 receptor plays a protective role in tumor necrosis factor-α-induced bone resorption lacunae on mouse calvariae

Nagano, K., Alles, N., Mian, A. H., Shimoda, A., Morimoto, N., Tamura, Y., Shimokawa, H., Akiyoshi, K., Ohya, K., & Aoki, K. (2011) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-011-0270-z · Cited by 17

Immunological tolerance in a mouse model of immune-mediated liver injury induced by 16,16 dimethyl PGE2 and PGE2-containing nanoscale hydrogels

Okamoto, T., Saito, T., Tabata, Y., & Üemoto, S. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.03.028 · Cited by 16

A polyion complex nanogel

Takeo, M., Mori, T., Niidome, T., Sawada, S., Akiyoshi, K., & Katayama, Y. (2012) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2012.09.015 · Cited by 12

Biodegradable dextran nanogels as functional carriers for the intracellular delivery of small interfering RNA

Raemdonck, K., Naeye, B., Høgset, A., et al. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.07.070 · Cited by 9

Smooth muscle cell differentiation from human bone marrow: Variations in cell type specific markers and Id gene expression in a new model of cell culture

Tréguer, K., Naye, F., Thiébaud, P., Fédou, S., Soulet, F., Thézé, N., & Faucheux, C. (2009) · Cell Biology International · doi:10.1016/j.cellbi.2009.02.003 · Cited by 9

Controlled drug delivery vehicles for cancer treatment and their performance

Senapati, S., Mahanta, A. K., Kumar, S., & Maiti, P. (2018) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-017-0004-3 · Cited by 2,167

Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts

Stewart, M. P., Langer, R., & Jensen, K. F. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00678 · Cited by 747

Drug self-delivery systems for cancer therapy

Qin, S.-Y., Zhang, A.-Q., Cheng, S.-X., Rong, L., & Zhang, X.-Z. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.016 · Cited by 532

Development of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges

Zhang, W., Mehta, A., Tong, Z., Esser, L., & Voelcker, N. H. (2021) · Advanced Science · doi:10.1002/advs.202003937 · Cited by 430

Polymeric Delivery of Therapeutic Nucleic Acids

Kumar, R., Santa Chalarca, C. F., Bockman, M. R., Bruggen, C. V., Grimme, C. J., Dalal, R. J., Hanson, M. G., Hexum, J. K., & Reineke, T. M. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00997 · Cited by 365